Dictyostelium discoideum: a promising centrosome model system.

Abstract:

:The centrosome of the slime mould Dictyostelium discoideum displays a morphology markedly different from centriolar centrosomes or yeast spindle pole bodies, while fulfilling the same conserved functions in the organization of the microtubule cytoskeleton. Recent advances suggest that the Dictyostelium centrosome may offer an interesting model system, usefully complementing other well-studied centrosome models. The establishment of an isolation procedure and the generation of a range of monoclonal antibodies have been achieved, which are important pre-requisites for biochemical investigation. Furthermore, the role of the centrosome in cell motility and centrosome duplication process have been investigated using cells with GFP-labelled centrosomes.

journal_name

Biol Cell

journal_title

Biology of the cell

authors

Daunderer C,Schliwa M,Gräf R

doi

10.1016/s0248-4900(99)80092-6

subject

Has Abstract

pub_date

1999-05-01 00:00:00

pages

313-20

issue

4-5

eissn

0248-4900

issn

1768-322X

pii

S0248-4900(99)80092-6

journal_volume

91

pub_type

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