Abstract:
:Interaction of sperm and egg at fertilization induces well-coordinated molecular events including specific recognition between species, adhesion and fusion, that lead to the formation of a zygote, a totipotent cell that develops into a new individual. A calcium signal, common to a great number of species, from marine invertebrates to mammals, is essential to activate the metabolism of the unfertilized oocyte. However, how fertilization triggers this calcium signal and initiates development of the early embryo is far from understood. The signaling pathways activated in eggs may be similar to those described in somatic cells, since changes in intracellular free calcium and in mitosis activating protein (MAP) kinase activity occur in both systems after activation. Several hypotheses are currently proposed, implying a spermatic ligand binding to a specific receptor expressed at the egg surface, or where the fused sperm either allows the transit of external calcium into the egg or injects one (or several) activating factor(s). It is still not known which of these ideas is true. We concentrate in this review on the possible signaling pathways involving IP3 (inositol trisphosphate), since its production is involved in most species to generate the fertilization calcium wave.
journal_name
Biol Celljournal_title
Biology of the cellauthors
Ciapa B,Chiri Sdoi
10.1016/s0248-4900(00)01065-0subject
Has Abstractpub_date
2000-07-01 00:00:00pages
215-33issue
3-4eissn
0248-4900issn
1768-322Xpii
S0248-4900(00)01065-0journal_volume
92pub_type
杂志文章,评审abstract::Different cytochemical and morphological parameters were used to compare the functional patterns of the erythrocytes in the transition from the trophic (yellow eel) to the reproductive (silver eel) phases of European eel (Anguilla anguilla L.). Data on the nucleus were obtained by microdensitometric (Feulgen reaction)...
journal_title:Biology of the cell
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journal_title:Biology of the cell
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journal_title:Biology of the cell
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更新日期:1986-01-01 00:00:00
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journal_title:Biology of the cell
pub_type: 杂志文章
doi:10.1111/j.1768-322x.1989.tb03013.x
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journal_title:Biology of the cell
pub_type: 杂志文章
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更新日期:1984-01-01 00:00:00
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journal_title:Biology of the cell
pub_type: 杂志文章
doi:10.1111/j.1768-322x.1984.tb00309.x
更新日期:1984-01-01 00:00:00
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journal_title:Biology of the cell
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
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journal_title:Biology of the cell
pub_type: 杂志文章
doi:10.1111/j.1768-322x.1986.tb00438.x
更新日期:1986-01-01 00:00:00
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journal_title:Biology of the cell
pub_type: 杂志文章
doi:10.1111/j.1768-322x.1990.tb00007.x
更新日期:1990-01-01 00:00:00
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journal_title:Biology of the cell
pub_type: 杂志文章
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更新日期:1985-01-01 00:00:00
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更新日期:1998-12-01 00:00:00
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journal_title:Biology of the cell
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更新日期:1994-01-01 00:00:00
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journal_title:Biology of the cell
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journal_title:Biology of the cell
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