Abstract:
:Heterozygous staggerer mice (Rora(+)/Rora(sg)) and control mice (Rora(+)/Rora(+)) of the same C57BL/6J strain background were tested in a spontaneous alternation task at 3 to 24 months old. The results demonstrated a decrement in long-term working memory as early as 6 months in Rora(+)/Rora(+) mice and at 3 months in Rora(+)/Rora(sg) mice. Previous studies showed that in both cases, neuronal number in the cerebellar cortex was normal. This suggests that age-dependent decrease in long-term working memory would be due to fine structural or biochemical changes preceding neuronal death in the cerebellum. Such subtle changes would occur more precociously in Rora(+)/Rora(sg) than in Rora(+)/Rora(+) mice. Also, short-term working memory was preserved in Rora(+)/Rora(+) mice as old as 24 months, but was impaired in 6-month-old Rora(+)/Rora(sg) mice.
journal_name
Behav Genetjournal_title
Behavior geneticsauthors
Caston J,Chianale C,Mariani Jdoi
10.1023/B:BEGE.0000017875.78571.a6subject
Has Abstractpub_date
2004-05-01 00:00:00pages
319-24issue
3eissn
0001-8244issn
1573-3297pii
481154journal_volume
34pub_type
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