Abstract：
:Testis specific protein, Y-encoded-like 2 (TSPYL2) regulates the expression of genes encoding glutamate receptors. Glutamate pathology is implicated in neurodevelopmental conditions such as autism spectrum disorder, attention deficit hyperactivity disorder (ADHD) and schizophrenia. In line with this, a microduplication incorporating the TSPYL2 locus has been reported in people with ADHD. However, the role of Tspyl2 remains unclear. Therefore here we used a Tspyl2 loss-of-function mouse model to directly examine how this gene impacts upon behavior and brain anatomy. We hypothesized that Tspyl2 knockout (KO) would precipitate a phenotype relevant to neurodevelopmental conditions. In line with this prediction, we found that Tspyl2 KO mice were marginally more active, had significantly impaired prepulse inhibition, and were significantly more 'sensitive' to the dopamine agonist amphetamine. In addition, the lateral ventricles were significantly smaller in KO mice. These findings suggest that disrupting Tspyl2 gene expression leads to behavioral and brain morphological alterations that mirror a number of neurodevelopmental psychiatric traits.
journal_name
Behav Genetjournal_title
Behavior geneticsauthors
Li Q,Chan SY,Wong KK,Wei R,Leung YO,Ding AY,Hui TC,Cheung C,Chua SE,Sham PC,Wu EX,McAlonan GMdoi
10.1007/s10519-015-9777-8subject
Has Abstractpub_date
2016-07-01 00:00:00pages
529-37issue
4eissn
0001-8244issn
1573-3297pii
10.1007/s10519-015-9777-8journal_volume
46pub_type
杂志文章abstract：:Previous studies have shown associations between single nucleotide polymorphisms (SNPs) in gamma aminobutyric acid receptor alpha 2 (GABRA2) and adolescent conduct disorder (CD) and alcohol dependence in adulthood, but not adolescent alcohol dependence. The present study was intended as a replication and extension of ...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-014-9653-y
更新日期：2014-07-01 00:00:00
abstract：:Univariate and multivariate analyses of the genetic and environmental contributions to variance in adipose tissue and adipose tissue distribution were carried out in early adolescents. Stature, weight, body mass index (BMI), and five subcutaneous skinfolds were measured at half-yearly intervals in 105 MZ and DZ twin p...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/a:1021671313974
更新日期：1998-07-01 00:00:00
abstract：:The facts concerning Kammerer's case are reviewed. Koestler's view that Krammerer was unjustly accused is presented and shown to be incorrect. ...
journal_title：Behavior genetics
pub_type： 传,历史文章,杂志文章
doi：10.1007/BF01066805
更新日期：1975-04-01 00:00:00
abstract：:Behaviors with high energetic costs may decrease in frequency in domestic animals as a response to selection for increased production. The aim of this study was to quantify production traits, foraging behavior, and social motivation in F2 progeny from a White Leghorn x red junglefowl intercross (n = 751-1046) and to p...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/a:1020880211144
更新日期：2002-11-01 00:00:00
abstract：:Sixty-six mice of 11 genetic stocks (the Bailey recombinant inbred strains CXBD, CXBE, CXBG, CXBH, CXBI, CXBJ, CXBK; their progenitor strains, BALB/cBy and C57BL/6By: and the reciprocal hybrids, B6CF and CB6F) were tested in a two-compartment apparatus and in a shuttlebox, with five measures taken relating to activity...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01066277
更新日期：1977-05-01 00:00:00
abstract：:Callous-unemotional (CU) traits comprise the core symptoms of psychopathy, yet no study has estimated the heritability of CU traits in a community sample of children using an instrument designed solely to assess CU traits. The current study uses data from 339 twin pairs aged 9-14 to examine the reliability and heritab...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-016-9831-1
更新日期：2017-03-01 00:00:00
abstract：:Males from the fifty selected generation of a selection program for aggressiveness in female Mus musculus (Ebert and Hyde, 1976) were tested to determine whether male aggressiveness showed a correlated response in selection for female aggressiveness. The results indicated that male aggression had not shown a correlate...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01065699
更新日期：1976-10-01 00:00:00
abstract：:A go/no-go operant task was used to assess the ability of male Long-Evans rats to discriminate between the urine odors from pairs of intact MHC congenic mice (C57BL/6-H-2Kb/J and C57BL/6-H-2Kbm1/ByJ), intact Y congenic mice (DBA1 and DBA1.C57BL10-Y), and castrated Y congenic mice of these two strains. The MHC congenic...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01082464
更新日期：1993-05-01 00:00:00
abstract：:Twin studies are useful for assessing the relative importance of genetic or heritable component from the environmental component. In this paper we develop a methodology to study the heritability of age-at-onset or lifespan traits, with application to analysis of twin survival data. Due to limited period of observation...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-007-9150-7
更新日期：2007-07-01 00:00:00
abstract：:Genetic strains of mice represent an important resource for research on the biological determinants of complex diseases and behavioral phenotypes. To date, the approaches used have had little success in identifying causal genes. We have evaluated brain gene expression in C57BL/6J (B6) and DBA/2J (D2) inbred mouse stra...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/B:BEGE.0000023648.78190.ee
更新日期：2004-07-01 00:00:00
abstract：:During middle childhood, continuous changes occur in electroencephalogram (EEG) coherence, an index of cortico-cortical connectivity of the brain. In the gradual development of EEG coher ence, occasional "growth spurts" are observed which coincide with periods of discontinuous development in cognition. Discontinuous d...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/a:1013357714500
更新日期：2001-11-01 00:00:00
abstract：:Using high resolution magnetic resonance imaging data, we examined the interrelationships between eight cerebral lobar volumetric measures via both exploratory and confirmatory factor analyses in a large sample (N = 484) of pediatric twins and singletons. These analyses suggest the presence of strong genetic correlati...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-010-9332-6
更新日期：2010-03-01 00:00:00
abstract：:The amygdala integrates and coordinates emotional and autonomic responses. The genetics that underlie variation in amygdala structure may be coupled to variation in levels of aggression, fear, anxiety, and affiliated behaviors. We systematically quantified the volume and cell populations of the basolateral amygdala co...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-006-9122-3
更新日期：2007-01-01 00:00:00
abstract：:In this article, we successfully apply the novel model selection method, Bayesian composite model space approach which has been used to map quantitative trait loci (QTL) for allelic substitution model, to map QTL for variance component model. The novel model selection approach has two advantages compared to the revers...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-009-9259-y
更新日期：2009-05-01 00:00:00
abstract：:Genomewide scan, as shown by recently published linkage studies on the behavior of mice or in psychiatry, provides evidence for replicated quantitative trait loci (QTL). Several studies of Alzheimer's disease have demonstrated the promise of moving from clinical diagnoses to biological signs for psychiatric investigat...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/a:1010222328509
更新日期：2001-01-01 00:00:00
abstract：:The present study explored the effects of infantile stimulation (i.e., neonatal handling or NH) on the performance of 18-month-old Roman high-avoidance (RHA/Verh) and low-avoidance (RLA/Verh) rats in a swimming pool matching-to-place (SPMP) test. This test (also called repeated acquisition and place learning-set parad...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/a:1015253807488
更新日期：2002-03-01 00:00:00
abstract：:Latent variable models are used in biological and social sciences to investigate characteristics that are not directly measurable. The generation of individual scores of latent variables can simplify subsequent analyses. However, missing measurements in real data complicate the calculation of scores. Missing observati...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-006-9123-2
更新日期：2007-03-01 00:00:00
abstract：:In previous electrophysiological experiments from hypopigmented animals (mice, rats, rabbits), single-unit recordings from both retinal ganglion axons and cells in the superior colliculus have demonstrated an increase in threshold in the dark-adapted state which is roughly proportional to the ocular melanin concentrat...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01067442
更新日期：1993-07-01 00:00:00
abstract：:Chickens homozygous for the Dominant white or wild-type allele of PMEL17 were subjected to a broad phenotyping in order to detect consistent differences between genotypes. To exclude feather pecking, the chickens were individually housed without physical contact, from the day of hatching, and tested for social, aggres...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-010-9379-4
更新日期：2011-03-01 00:00:00
abstract：:For many psychiatric conditions it is speculated that, rather than being single disease entities, they are a set of several disorders sharing clinical features but having (partly) different underlying causes. The possibility of measuring genetic variation on a large scale has given researchers new hope of identifying ...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-006-9135-y
更新日期：2007-05-01 00:00:00
abstract：:The escape efficiency of two closely related species of frogs, Odontophrynus cultripes (2n = 22) and the tetraploid O. americanus (4n = 44), were compared in a shuttle box and under simulated naturalistic conditions. O. americanus was generally superior to O. cultripes, and females tended to outperform males within bo...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01065462
更新日期：1981-05-01 00:00:00
abstract：:Feather pecking (FP) is a serious economic and welfare problem in the domestic fowl. It has recently been shown that the distribution of FP bouts within groups is heterogeneous and contains a sub-population of extreme feather peckers (EFP). The present study proposed a novel model to detect EFP hens. A mixture of two ...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-019-09971-w
更新日期：2020-01-01 00:00:00
abstract：:Current behavior genetic models can only employ limited types of phenotypic data, such as Likert scale data or continuous data, as variables. Here, a new method employing paired comparison data is presented within the framework of behavior genetic models. This model facilitates the estimation of genetic, shared enviro...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-007-9183-y
更新日期：2008-03-01 00:00:00
abstract：:Social aggregations of free-ranging cattle were studied in the Sonoran Desert of Mexico. Cows reared with animals of their own breed in isolation from other breeds maintained segregated social groups. Cows raised together in a mixed herd containing other breeds allied themselves with herd-mates regardless of breed. Ca...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01065562
更新日期：1990-05-01 00:00:00
abstract：:A powerful longitudinal data source, the National Longitudinal Survey of Youth Children data, allows measurement of behavior problems (BP) within a developmental perspective linking them to menarcheal timing (MT). In a preliminary analysis, we evaluate the bivariate relationships between BP measured at different devel...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-014-9676-4
更新日期：2015-01-01 00:00:00
abstract：:The initial experimental population of Drosophila persimilis was photopositive and slightly geonegative. In this respect, the initial population of D. persimilis differed from the experimental population of D. pseudoobscura, described by others, which was close to photo- and geotactic neutrality. In D. persimilis as i...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01066177
更新日期：1975-07-01 00:00:00
abstract：:We present a repeated-measures, genetic analysis of ethanol-induced anesthesia (sleep time) in mice from the inbred long-sleep (ILS) and short-sleep (ISS) strains of mice and their derived F1 and F2 generations. Mice (total N > 1300) were administered a 4.1 g/kg intraperitoneal dose of ethanol at two times, 7 to 10 da...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF02197243
更新日期：1995-01-01 00:00:00
abstract：:Selective breeding for initial sensitivity to ethanol has been carried out by a number of investigators in order to investigate the mechanisms by which ethanol brings about a myriad of effects on the mammalian central nervous system. In addition the availability of these selectively bred animals provides clues to the ...
journal_title：Behavior genetics
pub_type： 杂志文章,评审
doi：10.1007/BF01067420
更新日期：1993-03-01 00:00:00
abstract：:Lurcher mutant mice were impaired in spatial orientation and motor coordination in comparison to normal mice. Both groups improved across days in both invisible and visible water maze platform conditions. Contrary to normal mice, lurcher mutants did not improve over days in terms of the time taken to reach a side-bar ...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01071563
更新日期：1994-11-01 00:00:00
abstract：:Almost 40 years ago, evidence from large studies of adult twins and their relatives suggested that between 30 and 60% of the variance in social and political attitudes could be explained by genetic influences. However, these findings have not been widely accepted or incorporated into the dominant paradigms that explai...
journal_title：Behavior genetics
pub_type： 杂志文章,meta分析
doi：10.1007/s10519-014-9648-8
更新日期：2014-05-01 00:00:00
