Abstract：
:In this article, we successfully apply the novel model selection method, Bayesian composite model space approach which has been used to map quantitative trait loci (QTL) for allelic substitution model, to map QTL for variance component model. The novel model selection approach has two advantages compared to the reversible jump Markov chain Monte Carlo method. Firstly, it mixes well due to the fixedness of the model dimension; secondly, it can map multiple QTL with higher power especially in genome-wide QTL mapping; finally, in the new method, it is also easy to incorporate our prior information about the variance components, which may bring precise estimate for variance components. A series of simulation experiments were conducted to demonstrate the general characters of the proposed method. The computer program is written in FORTRAN language, which is also built into a software "BayesMapQTL", and they also can be used for real data analysis and are available for request.
journal_name
Behav Genetjournal_title
Behavior geneticsauthors
Fang M,Liu S,Jiang Ddoi
10.1007/s10519-009-9259-ysubject
Has Abstractpub_date
2009-05-01 00:00:00pages
337-46issue
3eissn
0001-8244issn
1573-3297journal_volume
39pub_type
杂志文章abstract：:Previous studies have shown associations between single nucleotide polymorphisms (SNPs) in gamma aminobutyric acid receptor alpha 2 (GABRA2) and adolescent conduct disorder (CD) and alcohol dependence in adulthood, but not adolescent alcohol dependence. The present study was intended as a replication and extension of ...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-014-9653-y
更新日期：2014-07-01 00:00:00
abstract：:Social aggregations of free-ranging cattle were studied in the Sonoran Desert of Mexico. Cows reared with animals of their own breed in isolation from other breeds maintained segregated social groups. Cows raised together in a mixed herd containing other breeds allied themselves with herd-mates regardless of breed. Ca...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01065562
更新日期：1990-05-01 00:00:00
abstract：:Genetic and environmental influences on problem behaviors were studied in a sample of international adoptees. Parental ratings of childrens' problem behaviors were obtained with the Child Behavior Checklist (CBCL). The sample (mean age, 12.4 years) comprised a group of biological siblings (111 pairs), a group of nonbi...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01067187
更新日期：1994-05-01 00:00:00
abstract：:Selective breeding for initial sensitivity to ethanol has been carried out by a number of investigators in order to investigate the mechanisms by which ethanol brings about a myriad of effects on the mammalian central nervous system. In addition the availability of these selectively bred animals provides clues to the ...
journal_title：Behavior genetics
pub_type： 杂志文章,评审
doi：10.1007/BF01067420
更新日期：1993-03-01 00:00:00
abstract：:This is the first report of data analyses from a consortium of longitudinal genetic-risk studies on offspring of schizophrenic parents (CLOSSER) who were followed from birth or mid-childhood to their early 20's or considerably older ages. Three of the CLOSSER studies provide data to enable us to address long-persistin...
journal_title：Behavior genetics
pub_type： 杂志文章,评审
doi：10.1007/s10519-005-3227-y
更新日期：2005-05-01 00:00:00
abstract：:The ε4 allele of the apolipoprotein (APOE) gene is a widely recognized genetic risk factor for developing Alzheimer's disease in older age. However, it is controversial whether there is a positive impact of the APOE ε4 allele on human cognitive performance in young adulthood, possibly representing a case of antagonist...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-019-09961-y
更新日期：2019-09-01 00:00:00
abstract：:A study was conducted to identify quantitative trait loci (QTLs) that affect learning in honeybees. Two F1 supersister queens were produced from a cross between two established lines that had been selected for differences in the speed at which they reverse a learned discrimination between odors. Different families of ...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/a:1012227308783
更新日期：2001-05-01 00:00:00
abstract：:The facts concerning Kammerer's case are reviewed. Koestler's view that Krammerer was unjustly accused is presented and shown to be incorrect. ...
journal_title：Behavior genetics
pub_type： 传,历史文章,杂志文章
doi：10.1007/BF01066805
更新日期：1975-04-01 00:00:00
abstract：:Inhibitory control (IC) is a dimension of child temperament that emerges in toddlerhood and involves the ability to regulate behavior in response to instructions or expectations. In general, children with low levels of IC have more cognitive and social difficulties, and higher levels of problem behaviors. Unfortunatel...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-009-9316-6
更新日期：2010-05-01 00:00:00
abstract：:The prevalence of marriage varies across the lifespan, as does its importance to reproduction and the nurturance of children. We examined genetic and environmental influences on self-reported marriage at each decade from 20 through 70 years of age, using data collected for the Duke Dementia Study, a followed-up subset...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-006-9132-1
更新日期：2007-03-01 00:00:00
abstract：:The heritability of human personality is well-established. Recent research indicates that nonadditive genetic effects, such as dominance and epistasis, play a large role in personality variation. One possible explanation for the latter finding is that there has been recent selection on human personality. To test this ...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-012-9537-y
更新日期：2012-07-01 00:00:00
abstract：:Differences between population-typical norms of individual variability were studied in five genetic lines of Japanese quail (Coturnix coturnix japonica); two (BL and RL) were bidirectionally selected for early approach preference between blue and red stimuli, two (Hi and Lo) for high and low imprintabilities to the sa...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01074309
更新日期：1992-09-01 00:00:00
abstract：:Male Drosophila melanogaster from lines artificially selected to have divergent life histories were tested to determine if they differed in their effects on female reproductive behavior. During the first 5 days after mating, males from short-generation populations caused females to lay eggs at a faster rate than did m...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF02361157
更新日期：1996-01-01 00:00:00
abstract：:Genetic strains of mice represent an important resource for research on the biological determinants of complex diseases and behavioral phenotypes. To date, the approaches used have had little success in identifying causal genes. We have evaluated brain gene expression in C57BL/6J (B6) and DBA/2J (D2) inbred mouse stra...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/B:BEGE.0000023648.78190.ee
更新日期：2004-07-01 00:00:00
abstract：:The most common alternative to a genetic explanation of left-handedness is that sinistrality arises because of birth stress factors. In a sample of 1398 subjects, the association between birth stress and left-handedness was confirmed. More importantly, it was found that left-handed mothers are more likely to have birt...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF02327575
更新日期：1995-11-01 00:00:00
abstract：:Martin and Wilson (1982) describe two forms of sampling bias in twin studies. One is "hard selection," where individuals above a threshold participate, and those below do not. The second is "soft selection," where the probability of including a pair of relatives varies over the range of the character. We present an al...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01065901
更新日期：1989-03-01 00:00:00
abstract：:Current behavior genetic models can only employ limited types of phenotypic data, such as Likert scale data or continuous data, as variables. Here, a new method employing paired comparison data is presented within the framework of behavior genetic models. This model facilitates the estimation of genetic, shared enviro...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-007-9183-y
更新日期：2008-03-01 00:00:00
abstract：:Taste perception allows most animals to find edible food, potential mates, and avoid ingesting toxic molecules. Intriguingly, a small group of Drosophila taste neurones (expressing Gr66a-Gal4) involved in the perception of bitter substances is also used to detect 7-tricosene (7-T), a male cuticular pheromone. Male fli...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-009-9286-8
更新日期：2009-09-01 00:00:00
abstract：:Individuals involved in a social interaction exhibit different behavioral traits that, in combination, form the individual's behavioral responses. Selectively bred strains of silver foxes (Vulpes vulpes) demonstrate markedly different behaviors in their response to humans. To identify the genetic basis of these behavi...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-016-9815-1
更新日期：2017-01-01 00:00:00
abstract：:Anxiety disorders are phenotypically complex and may involve multiple genetic influences on many neurotransmitter systems. Rodent tests used to investigate genetic influences on anxiety-like phenotypes have face and predictive validity as models for anxiety in humans. If multiple genes contribute additively to a trait...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/B:BEGE.0000009479.02183.1f
更新日期：2004-01-01 00:00:00
abstract：:A wealth of literature suggests that normative and heavy alcohol consumption continue to follow a historical pattern of greater prevalence among males as compared to females. Some prior research suggested that sex-specific factors might explain some of this gender gap. Generally speaking, though, more recent studies h...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-020-10004-0
更新日期：2020-09-01 00:00:00
abstract：:Behaviors with high energetic costs may decrease in frequency in domestic animals as a response to selection for increased production. The aim of this study was to quantify production traits, foraging behavior, and social motivation in F2 progeny from a White Leghorn x red junglefowl intercross (n = 751-1046) and to p...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/a:1020880211144
更新日期：2002-11-01 00:00:00
abstract：:A go/no-go operant task was used to assess the ability of male Long-Evans rats to discriminate between the urine odors from pairs of intact MHC congenic mice (C57BL/6-H-2Kb/J and C57BL/6-H-2Kbm1/ByJ), intact Y congenic mice (DBA1 and DBA1.C57BL10-Y), and castrated Y congenic mice of these two strains. The MHC congenic...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01082464
更新日期：1993-05-01 00:00:00
abstract：:Results obtained from previous studies of word recognition, reading component skills, and reading composite measures suggest that genetic factors may be more important as a cause for reading disability among children with higher IQ scores than among those with lower IQ scores. To investigate the genetic etiology of re...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/a:1016069012111
更新日期：2002-05-01 00:00:00
abstract：:Extreme sampling of sibling pairs has been shown to be efficient in terms of statistical power and sample sizes (in number of sibling pairs needed to genotype) to detect a quantitative trait locus (QTL) when the residual distribution is normal. In the present study, the efficiency of extreme sampling strategies to det...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/a:1014403827957
更新日期：2002-01-01 00:00:00
abstract：:The attempt to characterize high- and low-selected lines on new variables poses serious interpretative problems when replicate lines are not available. Modest but significant line differences on new measures may be due to genetic drift totally irrelevant to the originally selected trait. Often these differences are ex...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01066250
更新日期：1989-07-01 00:00:00
abstract：:Sex differences in genetic and environmental influences on criminal behavior against property were studied in a birth cohort of 6129 male and 7065 female Danish adoptees and their biological and adoptive parents. Both genetic and environmental factors were found to contribute to variation in liability to property crim...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01066164
更新日期：1989-05-01 00:00:00
abstract：:Gender-moderated gene-environment interactions are rarely explored, raising concerns about inaccurate specification of etiological models and inferential errors. The current study examined the influence of gender, negative and positive daily life events, and GABRA2 genotype (SNP rs279871) on alcohol dependence, testin...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-013-9607-9
更新日期：2013-09-01 00:00:00
abstract：:During middle childhood, continuous changes occur in electroencephalogram (EEG) coherence, an index of cortico-cortical connectivity of the brain. In the gradual development of EEG coher ence, occasional "growth spurts" are observed which coincide with periods of discontinuous development in cognition. Discontinuous d...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/a:1013357714500
更新日期：2001-11-01 00:00:00
abstract：:The multiple regression methodology proposed by DeFries and Fulker (DF; 1985, 1988) for the analysis of twin data is compared with maximum-likelihood estimation of genetic and environmental parameters from covariance structure. Expectations for the regression coefficients from submodels omitting the h2 and c2 terms ar...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01066617
更新日期：1992-07-01 00:00:00
