Abstract:
:Selective breeding for initial sensitivity to ethanol has been carried out by a number of investigators in order to investigate the mechanisms by which ethanol brings about a myriad of effects on the mammalian central nervous system. In addition the availability of these selectively bred animals provides clues to the causes of the genetic predisposition of humans to alcoholism. Eventually it is envisioned that the synteny between the mouse and human genomes will allow identification of specific genes responsible for acute effects of ethanol in both species as well as clues as to how alcoholism in humans can be better identified, prevented, and treated.
journal_name
Behav Genetjournal_title
Behavior geneticsauthors
Deitrich RAdoi
10.1007/BF01067420subject
Has Abstractpub_date
1993-03-01 00:00:00pages
153-62issue
2eissn
0001-8244issn
1573-3297journal_volume
23pub_type
杂志文章,评审abstract::To study the relationship between genetics and epilepsy, Wistar rats susceptible to audiogenic seizure were selected from the main breeding stock of the Ribeirão Preto School of Medicine at the University of São Paulo, Brazil, and inbred. The criteria for selection were the highest seizure severity index (SI) and shor...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/a:1021099432759
更新日期:2003-01-01 00:00:00
abstract::The multiple regression methodology proposed by DeFries and Fulker (DF; 1985, 1988) for the analysis of twin data is compared with maximum-likelihood estimation of genetic and environmental parameters from covariance structure. Expectations for the regression coefficients from submodels omitting the h2 and c2 terms ar...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01066617
更新日期:1992-07-01 00:00:00
abstract::Previous studies suggest that brain opioid activity decreases aggression in animal models. The main objective of the current study was to examine the possible genetic relationship between intermale aggression and brain levels of enkephalins, endorphins, and dynorphins in 11 inbred strains of mice. Pursuit, rattling, a...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/a:1025774716976
更新日期:2003-09-01 00:00:00
abstract::Thirty-one female subjects with Turner syndrome (TS) and 31 normal females matched for age and verbal IQ were given a spatial task requiring the mental rotation of geometric figures. The results revealed a poorer performance by the TS group for most items involving rotations. The relationship between reaction time and...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01073648
更新日期:1980-09-01 00:00:00
abstract::Extreme sampling of sibling pairs has been shown to be efficient in terms of statistical power and sample sizes (in number of sibling pairs needed to genotype) to detect a quantitative trait locus (QTL) when the residual distribution is normal. In the present study, the efficiency of extreme sampling strategies to det...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/a:1014403827957
更新日期:2002-01-01 00:00:00
abstract::Here we provide a detailed description of the genome-wide information available on the National Longitudinal Study of Adolescent to Adult Health (Add Health) sibling pair subsample (Harris et al. in Twin Res Hum Genet 16:391-398, 2013). A total of 2,020 samples were genotyped (including duplicates) arising from 1946 A...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-014-9692-4
更新日期:2015-01-01 00:00:00
abstract::Males from the fifty selected generation of a selection program for aggressiveness in female Mus musculus (Ebert and Hyde, 1976) were tested to determine whether male aggressiveness showed a correlated response in selection for female aggressiveness. The results indicated that male aggression had not shown a correlate...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01065699
更新日期:1976-10-01 00:00:00
abstract::Interpretation of studies using single gene mutants is complicated by possible epistatic interactions with genetic background. Dopamine D2 receptor (Drd2) knockout mice on a C57BL/6 (B6) background show decreased basal locomotion, ethanol preference and ethanol-induced ataxia. Epistatic interactions were studied by ex...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/a:1023450625826
更新日期:2003-05-01 00:00:00
abstract::This study uses longitudinal population-based samples of young siblings to examine the effects of two hypothesized moderators of early externalizing behaviors: parental emotional support and family socioeconomic status. The first sample, a twin sample from the Early Childhood Longitudinal Study-Birth Cohort (ECLS-B), ...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-014-9664-8
更新日期:2014-09-01 00:00:00
abstract::We developed a zygosity questionnaire for use in young twins and assessed its validity using the results of DNA diagnosis. The participants were divided into two groups: 105 pairs of adolescent twins (12-16 years old), 47 pairs of child twins (2-12 years old), and their respective parents. The DNA diagnosis of zygosit...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/a:1021660506222
更新日期:1999-03-01 00:00:00
abstract::Workers from colonies of Cape honeybees show marked phenotypic differences in performance in proboscis extension reflex (PER) conditioning. Analysis of these differences using parthenogenetic offspring groups permitted the estimation of genotypic values and revealed a high degree of genetic variability that is evident...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01065820
更新日期:1991-05-01 00:00:00
abstract::Mutations on the period locus of Drosophila melanogaster influence circadian periods as well as the rhythm in inter-pulse intervals in male courtship song; perL mutations produce long circadian periods and courtship song rhythms and per(s) mutations produce short circadian periods and courtship song rhythms. Thus, the...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/a:1021625819967
更新日期:1998-09-01 00:00:00
abstract::In epidemiological and twin populations, prior interview studies have identified an externalizing spectrum of disorders. Could this be detected utilizing objective registry data? In 20,603 twin pairs from the Swedish Twin Registry, we obtained information from national medical, criminal and pharmacy records on drug ab...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-015-9741-7
更新日期:2016-03-01 00:00:00
abstract::In a sample of 1,940 Dutch 7-year-old twin pairs we studied the etiology of individual differences in Internalizing and Externalizing behavioral problems. For the majority of twins in the sample, both maternal and paternal ratings of behavioral problems were obtained from the Child Behavior Checklist. This made it pos...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/a:1025369525924
更新日期:2003-07-01 00:00:00
abstract::Recent studies have identified genes that influence the length of the circadian period maintained by mice housed under constant lighting conditions. However, a less studied circadian activity variable is the amplitude of daily oscillations in locomotor activity. This parameter reflects spontaneous activity exhibited u...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/a:1021657800287
更新日期:1999-09-01 00:00:00
abstract::A central issue in psychiatric genetics is whether positive findings replicate. Zubenko et al. (2002b, Mol. Psychiatry 7:460-467) reported an association of the 124-bp allele of D2S2944 with recurrent early-onset major depression for females. We tested for association of this allele to continuous measures of anxiety, ...
journal_title:Behavior genetics
pub_type: 杂志文章,多中心研究
doi:10.1007/s10519-005-9006-y
更新日期:2006-01-01 00:00:00
abstract::Six strains of the cosmopolitan species D. immigrans from the Australian life zone plus one from the USA, show weak sexual isolation and more rarely sexual selection. Levels of sexual isolation cannot be related to geographic distances. Assortative mating may have evolved as a byproduct of ecological divergence. ...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01065601
更新日期:1980-07-01 00:00:00
abstract::We review the literature on the familial resemblance of body mass index (BMI) and other adiposity measures and find strikingly convergent results for a variety of relationships. Results from twin studies suggest that genetic factors explain 50 to 90% of the variance in BMI. Family studies generally report estimates of...
journal_title:Behavior genetics
pub_type: 杂志文章,评审
doi:10.1023/a:1025635913927
更新日期:1997-07-01 00:00:00
abstract::The transmission of social attitudes has been investigated as a possible model of cultural inheritance in a sample of 3810 twin pairs from the Australian National Health and Medical Research Twin Registry. Six social attitude factors were identified and univariate genetic models fitted to scores on each factor. A join...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01066792
更新日期:1992-01-01 00:00:00
abstract::We investigated regional grey matter (GM) density in adolescents with Down syndrome (DS) compared to age-matched controls and correlated MRI data with neuropsychological measures in the DS group. Inter-group comparisons documented several GM concentration abnormalities in the participants with DS compared to controls....
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-011-9448-3
更新日期:2011-05-01 00:00:00
abstract::A large sample of adult twins (1117 pairs), who were concordant for having had children were asked to report on their child-rearing practices. A 14-item version of the Parental Bonding Instrument (PBI) was used to assess rearing practices of parent twins. The two factors of Care and Overprotection, commonly found in o...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01067533
更新日期:1994-07-01 00:00:00
abstract::Substantial progress has been made recently in analyses of longitudinal twin and family data, principally for two reasons. The first is the continuing development of more refined models for describing longitudinal data; the second is the widespread availability of analytic methods (e.g. LISREL) with which to implement...
journal_title:Behavior genetics
pub_type: 评论,杂志文章
doi:10.1007/BF01067000
更新日期:1992-03-01 00:00:00
abstract::Selective breeding has been used to produce lines of mice differing in sensitivity to the hypothermic effects of ethanol (EtOH). Two genetically independent HOT (insensitive) and two COLD (sensitive) lines are maintained along with two nonselected control (CON) lines. The breeding program is currently in selected gene...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01067713
更新日期:1990-07-01 00:00:00
abstract::This paper uses data from the National Longitudinal Study of Adolescent Health to examine the extent to which school-level social and institutional factors moderate genetic tendencies to smoke cigarettes. Our analysis relies on a sub-sample of 1,198 sibling and twin pairs nested within 84 schools. We develop a multile...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-008-9197-0
更新日期:2008-05-01 00:00:00
abstract::In the course of the East Flanders Prospective Twin Survey (EFPTS), handedness was assessed as part of a genealogical study (Meulemans et al., 1995) in 1616 twins (808 twin pairs) aged 6 to 28. Our findings are that, in this large population-based study with known placentation and zygosity, the often observed higher f...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF02359484
更新日期:1996-07-01 00:00:00
abstract::Percentages of left-handed relatives were compared between subgroups of left-handers and of right-handers to test the prediction that the subgroups are ordered for probability of carrying the rs +/gene (hypothesized by the right-shift theory of handedness). Data included families of undergraduates and Open University ...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01067928
更新日期:1994-01-01 00:00:00
abstract::A model to analyze resemblances of twins and parents using LISREL is outlined and applied to sports participation and heart-rate data. Sports participation and heart rate were measured in 44 monozygotic and 46 dizygotic adolescent twin pairs and in their parents. Genetic factors influence variation in both sports beha...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01065888
更新日期:1989-01-01 00:00:00
abstract::If appropriately determined, recombinant-inbred (RI) strain means provide an excellent method for determining genetic correlations among complex characters. However, little systematic attention has been paid to important environmental influences on strain means such as random effects due to litter membership or system...
journal_title:Behavior genetics
pub_type: 杂志文章,评审
doi:10.1007/BF01066634
更新日期:1992-11-01 00:00:00
abstract::In previous electrophysiological experiments from hypopigmented animals (mice, rats, rabbits), single-unit recordings from both retinal ganglion axons and cells in the superior colliculus have demonstrated an increase in threshold in the dark-adapted state which is roughly proportional to the ocular melanin concentrat...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01067442
更新日期:1993-07-01 00:00:00
abstract::Effective mapping strategies for quantitative trains must allow for the detection of the more important quantitative trait loci (QTLs) while minimizing false positives. Type I (false-positive) and Type II (false-negative) error rates were estimated from a computer simulation of QTL mapping in the BXD recombinant inbre...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF02359892
更新日期:1996-03-01 00:00:00