Response to selection for sensitivity to ethanol hypothermia: genetic analyses.

Abstract:

:Selective breeding has been used to produce lines of mice differing in sensitivity to the hypothermic effects of ethanol (EtOH). Two genetically independent HOT (insensitive) and two COLD (sensitive) lines are maintained along with two nonselected control (CON) lines. The breeding program is currently in selected generation 14, and HOT and COLD mice differ by about 4 degrees C in selected hypothermic response. Estimates of heritability indicate that approximately 20% of the variance in EtOH-induced hypothermic response in mice is of additive genetic origin. Inbreeding has increased at a rate of about 1.7% per generation and no fertility problems have been detected as a result of selection. Projects designed to evaluate apparent correlated responses to selection are discussed.

journal_name

Behav Genet

journal_title

Behavior genetics

authors

Phillips TJ,Terdal ES,Crabbe JC

doi

10.1007/BF01067713

subject

Has Abstract

pub_date

1990-07-01 00:00:00

pages

473-80

issue

4

eissn

0001-8244

issn

1573-3297

journal_volume

20

pub_type

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