Diagnosis of zygosity by questionnaire and polymarker polymerase chain reaction in young twins.

Abstract:

:We developed a zygosity questionnaire for use in young twins and assessed its validity using the results of DNA diagnosis. The participants were divided into two groups: 105 pairs of adolescent twins (12-16 years old), 47 pairs of child twins (2-12 years old), and their respective parents. The DNA diagnosis of zygosity was made with polymarker polymerase chain reaction (PCR) amplification of five loci, using the AmpliType PM PCR Amplification and Typing Kit; this method has an accuracy rate of 99.0%. A parsimonious model for each sample was established using stepwise logistic regression analysis of the 20 items of the questionnaire. The total accuracy rate of the model was satisfactory for both parental reports (three items) and self-reports (three items) of adolescent twins (97.4 and 95.6%, respectively), while that for parental reports on child twins (two items) was less satisfactory (92.5%). For adolescent twins, if DNA diagnostic workups were limited to those with discordant reports either from themselves or from their parents, the accuracy rate increased to 100% for parental reports and 98% for self-reports.

journal_name

Behav Genet

journal_title

Behavior genetics

authors

Chen WJ,Chang HW,Wu MZ,Lin CC,Chang C,Chiu YN,Soong WT

doi

10.1023/a:1021660506222

subject

Has Abstract

pub_date

1999-03-01 00:00:00

pages

115-23

issue

2

eissn

0001-8244

issn

1573-3297

journal_volume

29

pub_type

杂志文章
  • Genetic analysis of differences in behavioral reactivity to neonatal injection of testosterone in female mice.

    abstract::A genetic analysis of differences in reactivity to early exposure of female BALB/cBy and C57BL/6By mice to testosterone was performed using the C x B recombinant-inbred (RI) strains. RI female mice were given a single injection of 1 mg of testosterone propionate on day 4 of life and observed in adulthood in the presen...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/BF01070741

    authors: Michard-Vanhée C,Roubertoux P

    更新日期:1990-01-01 00:00:00

  • Short-Term Genetic Selection for Adolescent Locomotor Sensitivity to Delta9-Tetrahydrocannabinol (THC).

    abstract::Cannabis use is linked to positive and negative outcomes. Identifying genetic targets of susceptibility to the negative effects of cannabinoid use is of growing importance. The current study sought to complete short-term selective breeding for adolescent sensitivity and resistance to the locomotor effects of a single ...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-018-9894-2

    authors: Kasten CR,Zhang Y,Mackie K,Boehm SL 2nd

    更新日期:2018-05-01 00:00:00

  • Natural genetic variation in complex mating behaviors of male Drosophila melanogaster.

    abstract::Mating behavior, including courtship and copulation, is a main component of male fitness, especially in species with no parental care. Variation in this behavior can thus be a target for mate choice and sexual selection, and can lead to evolution. The fruit fly, Drosophila melanogaster, has well-documented complex mal...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-008-9204-5

    authors: Ruedi EA,Hughes KA

    更新日期:2008-07-01 00:00:00

  • Identification of quantitative trait Loci for anxiety and locomotion phenotypes in rat recombinant inbred strains.

    abstract::Anxiety disorders are phenotypically complex and may involve multiple genetic influences on many neurotransmitter systems. Rodent tests used to investigate genetic influences on anxiety-like phenotypes have face and predictive validity as models for anxiety in humans. If multiple genes contribute additively to a trait...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1023/B:BEGE.0000009479.02183.1f

    authors: Conti LH,Jirout M,Breen L,Vanella JJ,Schork NJ,Printz MP

    更新日期:2004-01-01 00:00:00

  • Longitudinal genetic analysis of EEG coherence in young twins.

    abstract::During middle childhood, continuous changes occur in electroencephalogram (EEG) coherence, an index of cortico-cortical connectivity of the brain. In the gradual development of EEG coher ence, occasional "growth spurts" are observed which coincide with periods of discontinuous development in cognition. Discontinuous d...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1023/a:1013357714500

    authors: van Baal GC,Boomsma DI,de Geus EJ

    更新日期:2001-11-01 00:00:00

  • Quantitative trait locus mapping: fishing strategy or replicable results?

    abstract::Genomewide scan, as shown by recently published linkage studies on the behavior of mice or in psychiatry, provides evidence for replicated quantitative trait loci (QTL). Several studies of Alzheimer's disease have demonstrated the promise of moving from clinical diagnoses to biological signs for psychiatric investigat...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1023/a:1010222328509

    authors: Roubertoux PL,Le Roy-Duflos I

    更新日期:2001-01-01 00:00:00

  • Analysis of two-way escape-avoidance conditioning measures from a diallel cross of eight strains of rats.

    abstract::In a study designed to investigate genotype-environment interaction, eight strains of laboratory rats were crossbred in a replicated diallel cross employing infantile stimulation and its absence as environmental treatments. This paper reports on measures of the acquisition of two-way escape-avoidance conditioning, com...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/BF01070816

    authors: Wilcock J,Fulker DW,Broadhurst PL

    更新日期:1981-07-01 00:00:00

  • Decomposition of Mean Sex Differences in Alcohol Use Within a Genetic Factor Model.

    abstract::A wealth of literature suggests that normative and heavy alcohol consumption continue to follow a historical pattern of greater prevalence among males as compared to females. Some prior research suggested that sex-specific factors might explain some of this gender gap. Generally speaking, though, more recent studies h...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-020-10004-0

    authors: Richardson GB,Boutwell BB

    更新日期:2020-09-01 00:00:00

  • Multiple raters of disruptive child behavior: using a genetic strategy to examine shared views and bias.

    abstract::Most research on child behavior incorporates information from different individuals. While agreement between informants is generally only modest, there is little understanding of the processes underlying disagreement. In twin studies, differential agreement among raters for MZ and DZ twins is of particular concern. Th...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/BF02197280

    authors: Simonoff E,Pickles A,Hewitt J,Silberg J,Rutter M,Loeber R,Meyer J,Neale M,Eaves L

    更新日期:1995-07-01 00:00:00

  • Do schools moderate the genetic determinants of smoking?

    abstract::This paper uses data from the National Longitudinal Study of Adolescent Health to examine the extent to which school-level social and institutional factors moderate genetic tendencies to smoke cigarettes. Our analysis relies on a sub-sample of 1,198 sibling and twin pairs nested within 84 schools. We develop a multile...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-008-9197-0

    authors: Boardman JD,Saint Onge JM,Haberstick BC,Timberlake DS,Hewitt JK

    更新日期:2008-05-01 00:00:00

  • Homeostatic drive counteracting selection for positive and negative phototaxis and geotaxis in Drosophila pseudoobscura.

    abstract::Tested in Hirsch-Hadler mazes, Drosophila pseudoobscura is on the average geoneutral and photoneutral. Strongly geo- and photopositive and geo- and photonegative populations can be obtained by artificial selection, but upon relaxation of the selection they tend to relapse toward neutrality. This genetic homeostasis is...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/BF01065728

    authors: Levene H,Dobzhansky T

    更新日期:1976-07-01 00:00:00

  • Gene×Environment interactions in early externalizing behaviors: parental emotional support and socioeconomic context as moderators of genetic influences?

    abstract::This study uses longitudinal population-based samples of young siblings to examine the effects of two hypothesized moderators of early externalizing behaviors: parental emotional support and family socioeconomic status. The first sample, a twin sample from the Early Childhood Longitudinal Study-Birth Cohort (ECLS-B), ...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-014-9664-8

    authors: Cheung AK,Harden KP,Tucker-Drob EM

    更新日期:2014-09-01 00:00:00

  • Developmental isolation and subsequent adult behavior of Drosophila paulistorum. V. Survey of six sibling species.

    abstract::In an investigation into the effects of developmental isolation from all conspecifics, the Drosophila willistoni group of six sibling species responded to differing degrees: all six are reproductively isolated from D. paulistorum, the tester species. Drosophila pavlovskiana, a narrow endemic, proved the most vulnerabl...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1023/a:1021494023660

    authors: Kim YK,Ehrman L

    更新日期:1999-01-01 00:00:00

  • A twin study of intracerebral volumetric relationships.

    abstract::Using high resolution magnetic resonance imaging data, we examined the interrelationships between eight cerebral lobar volumetric measures via both exploratory and confirmatory factor analyses in a large sample (N = 484) of pediatric twins and singletons. These analyses suggest the presence of strong genetic correlati...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-010-9332-6

    authors: Schmitt JE,Wallace GL,Lenroot RK,Ordaz SE,Greenstein D,Clasen L,Kendler KS,Neale MC,Giedd JN

    更新日期:2010-03-01 00:00:00

  • Activity rhythms in inbred mice. I. Genetic analysis with recombinant inbred strains.

    abstract::Rhythm of activity of inbred mice was recorded automatically by a set of actographs. This rhythm was characterized by six indices in the temporal and frequency domains. Two methods of genetic analysis were applied to these indices using parental strains BALB/c and C57BL/6, the reciprocal F1's, and the seven recombinan...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/BF01066331

    authors: Beau J

    更新日期:1991-03-01 00:00:00

  • An Extended Twin-Pedigree Study of Neuroticism in the Netherlands Twin Register.

    abstract::For the participants in the Netherlands Twin Register (NTR) we constructed the extended pedigrees which specify all relations among nuclear and larger twin families in the register. A total of 253,015 subjects from 58,645 families were linked to each other, to the degree that we had information on the relations among ...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-017-9872-0

    authors: Boomsma DI,Helmer Q,Nieuwboer HA,Hottenga JJ,de Moor MH,van den Berg SM,Davies GE,Vink JM,Schouten MJ,Dolan CV,Willemsen G,Bartels M,van Beijsterveldt TCEM,Ligthart L,de Geus EJ

    更新日期:2018-01-01 00:00:00

  • Modeling genetic and environmental factors to increase heritability and ease the identification of candidate genes for birth weight: a twin study.

    abstract::Heritability estimates of birth weight have been inconsistent. Possible explanations are heritability changes during gestational age or the influence of covariates (e.g. chorionicity). The aim of this study was to model birth weights of twins across gestational age and to quantify the genetic and environmental compone...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-007-9170-3

    authors: Gielen M,Lindsey PJ,Derom C,Smeets HJ,Souren NY,Paulussen AD,Derom R,Nijhuis JG

    更新日期:2008-01-01 00:00:00

  • Forward Genetic Screening Using Behavioral Tests in Zebrafish: A Proof of Concept Analysis of Mutants.

    abstract::The zebrafish enjoys several advantages over other model organisms. It is small, easy to maintain, prolific, and numerous genetic tools are available for it. For example, forward genetic screens have allowed investigators to identify important genes potentially involved in a variety of functions from embryogenesis to ...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-016-9818-y

    authors: Gerlai R,Poshusta TL,Rampersad M,Fernandes Y,Greenwood TM,Cousin MA,Klee EW,Clark KJ

    更新日期:2017-01-01 00:00:00

  • Human parental behavior: evidence for genetic influence and potential implication for gene-culture transmission.

    abstract::A large sample of adult twins (1117 pairs), who were concordant for having had children were asked to report on their child-rearing practices. A 14-item version of the Parental Bonding Instrument (PBI) was used to assess rearing practices of parent twins. The two factors of Care and Overprotection, commonly found in o...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/BF01067533

    authors: Pérusse D,Neale MC,Heath AC,Eaves LJ

    更新日期:1994-07-01 00:00:00

  • Individual differences in handedness and specific speech and language impairment: evidence against a genetic link.

    abstract::Data from two twin studies were used to address two related questions. First, is there any association between handedness and specific speech and language impairment (SSLI) in children? Second, is there genetic influence on individual differences in handedness and, if so, are the same genes implicated in the cause of ...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1023/a:1012239617367

    authors: Bishop DV

    更新日期:2001-07-01 00:00:00

  • Tspyl2 Loss-of-Function Causes Neurodevelopmental Brain and Behavior Abnormalities in Mice.

    abstract::Testis specific protein, Y-encoded-like 2 (TSPYL2) regulates the expression of genes encoding glutamate receptors. Glutamate pathology is implicated in neurodevelopmental conditions such as autism spectrum disorder, attention deficit hyperactivity disorder (ADHD) and schizophrenia. In line with this, a microduplicatio...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-015-9777-8

    authors: Li Q,Chan SY,Wong KK,Wei R,Leung YO,Ding AY,Hui TC,Cheung C,Chua SE,Sham PC,Wu EX,McAlonan GM

    更新日期:2016-07-01 00:00:00

  • Investigating age differences in the genetic and environmental structure of the tridimensional personality questionnaire in later adulthood.

    abstract::In this study we examined cross-sectional age differences in means, phenotypic covariance structure, and the underlying genetic and environmental structure of four personality constructs from Cloninger's personality system: Novelty Seeking (NS), Harm Avoidance (HA), Reward Dependence (RD), and Persistence (PS). Study ...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1023/a:1022558002760

    authors: Heiman N,Stallings MC,Hofer SM,Hewitt JK

    更新日期:2003-03-01 00:00:00

  • A Novel Model to Explain Extreme Feather Pecking Behavior in Laying Hens.

    abstract::Feather pecking (FP) is a serious economic and welfare problem in the domestic fowl. It has recently been shown that the distribution of FP bouts within groups is heterogeneous and contains a sub-population of extreme feather peckers (EFP). The present study proposed a novel model to detect EFP hens. A mixture of two ...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-019-09971-w

    authors: Iffland H,Wellmann R,Preuß S,Tetens J,Bessei W,Piepho HP,Bennewitz J

    更新日期:2020-01-01 00:00:00

  • Twin analysis on paired comparison data.

    abstract::Current behavior genetic models can only employ limited types of phenotypic data, such as Likert scale data or continuous data, as variables. Here, a new method employing paired comparison data is presented within the framework of behavior genetic models. This model facilitates the estimation of genetic, shared enviro...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-007-9183-y

    authors: Ozaki K

    更新日期:2008-03-01 00:00:00

  • Pathways Between a Polygenic Score for Educational Attainment and Higher Educational Attainment in an African American Sample.

    abstract::We investigated the extent to which performance on standardized achievement tests, executive function (EF), and aggression in childhood and adolescence accounted for the relationship between a polygenic score for educational attainment (EA PGS) and years of education in a community sample of African Americans. Partici...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-019-09982-7

    authors: Rabinowitz JA,Kuo SI,Domingue B,Smart M,Felder W,Benke K,Maher BS,Ialongo NS,Uhl G

    更新日期:2020-01-01 00:00:00

  • Genetic variance in a component of the language acquisition device: ROBO1 polymorphisms associated with phonological buffer deficits.

    abstract::The region containing ROBO1 (Chromosome 3p12.3) has been implicated as a susceptibility gene for reading disorder and language deficit by translocation and linkage data. No association studies have yet been reported supporting any candidate gene. Here we report the first association of this gene with language deficits...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-010-9402-9

    authors: Bates TC,Luciano M,Medland SE,Montgomery GW,Wright MJ,Martin NG

    更新日期:2011-01-01 00:00:00

  • The case of The Case of the Midwife Toad.

    abstract::The facts concerning Kammerer's case are reviewed. Koestler's view that Krammerer was unjustly accused is presented and shown to be incorrect. ...

    journal_title:Behavior genetics

    pub_type: 传,历史文章,杂志文章

    doi:10.1007/BF01066805

    authors: Aronson LR

    更新日期:1975-04-01 00:00:00

  • The Inositol 1,4,5-triphosphate kinase1 gene affects olfactory reception in Drosophila melanogaster.

    abstract::The Inositol 1,4,5-triphosphate (IP3) route is one of the two main transduction cascades that mediate olfactory reception in Drosophila melanogaster. The activity of IP3 kinase1 reduces the levels of this substrate by phosphorylation into inositol 1,3,4,5-tetrakiphosphate (IP4). We show here that the gene is expressed...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-005-9031-x

    authors: Gomez-Diaz C,Martin F,Alcorta E

    更新日期:2006-03-01 00:00:00

  • Spatial memory of heterozygous staggerer (Rora(+)/Rora(sg)) versus normal (Rora(+)/Rora(+)) mice during aging.

    abstract::Heterozygous staggerer mice (Rora(+)/Rora(sg)) and control mice (Rora(+)/Rora(+)) of the same C57BL/6J strain background were tested in a spontaneous alternation task at 3 to 24 months old. The results demonstrated a decrement in long-term working memory as early as 6 months in Rora(+)/Rora(+) mice and at 3 months in ...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1023/B:BEGE.0000017875.78571.a6

    authors: Caston J,Chianale C,Mariani J

    更新日期:2004-05-01 00:00:00

  • Assortative mating in Drosophila adapted to a microsite ecological gradient.

    abstract::Elucidating the causes of population divergence, and ultimately speciation, is a central objective of evolutionary biology. A number of previous studies of Drosophila populations from the Nahal Oren canyon (Mt Carmel, Israel) revealed significant interslope differences for a complex of fitness and behavioral traits. P...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-005-6119-2

    authors: Singh SR,Rashkovetsky E,Iliadi K,Nevo E,Korol A

    更新日期:2005-11-01 00:00:00