Abstract:
:We developed a zygosity questionnaire for use in young twins and assessed its validity using the results of DNA diagnosis. The participants were divided into two groups: 105 pairs of adolescent twins (12-16 years old), 47 pairs of child twins (2-12 years old), and their respective parents. The DNA diagnosis of zygosity was made with polymarker polymerase chain reaction (PCR) amplification of five loci, using the AmpliType PM PCR Amplification and Typing Kit; this method has an accuracy rate of 99.0%. A parsimonious model for each sample was established using stepwise logistic regression analysis of the 20 items of the questionnaire. The total accuracy rate of the model was satisfactory for both parental reports (three items) and self-reports (three items) of adolescent twins (97.4 and 95.6%, respectively), while that for parental reports on child twins (two items) was less satisfactory (92.5%). For adolescent twins, if DNA diagnostic workups were limited to those with discordant reports either from themselves or from their parents, the accuracy rate increased to 100% for parental reports and 98% for self-reports.
journal_name
Behav Genetjournal_title
Behavior geneticsauthors
Chen WJ,Chang HW,Wu MZ,Lin CC,Chang C,Chiu YN,Soong WTdoi
10.1023/a:1021660506222subject
Has Abstractpub_date
1999-03-01 00:00:00pages
115-23issue
2eissn
0001-8244issn
1573-3297journal_volume
29pub_type
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