Quantitative study of the response to genetic selection of the Wistar audiogenic rat strain (WAR).

Abstract:

:To study the relationship between genetics and epilepsy, Wistar rats susceptible to audiogenic seizure were selected from the main breeding stock of the Ribeirão Preto School of Medicine at the University of São Paulo, Brazil, and inbred. The criteria for selection were the highest seizure severity index (SI) and shortest latencies of the first running fit (LI). Because behavioral response to sound stimulation (120 dB) at 70 to 78 days of age was very stable, SI and LI were evaluated within this age range. Analysis of 9450 observations in 1575 animals from the 3rd to 17th generations demonstrated significant effects of generation, parity, and litter on SI and of generation and litter on LI. The SI and LI averages were, respectively, 37.13 and 22.82 s in the 3rd generation and 83.06 and 7.84 in the 17th generation. Heritabilities of both characters were estimated, by maximum likelihood, as 0.37 +/- 0.066 and 0.44 +/- 0.059, respectively. Because a significant regression related individual breeding values for both SI and LI to generation number, we concluded that genetic selection has a positive impact on the traits analyzed. Therefore, the Wistar audiogenic rat (WAR) strain appears, as per the 17th to 20th generations of genetic selection to be an audiogenic rat strain suitable for epilepsy studies.

journal_name

Behav Genet

journal_title

Behavior genetics

authors

Doretto MC,Fonseca CG,Lôbo RB,Terra VC,Oliveira JA,Garcia-Cairasco N

doi

10.1023/a:1021099432759

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

33-42

issue

1

eissn

0001-8244

issn

1573-3297

journal_volume

33

pub_type

杂志文章
  • Genetic and environmental influences on child reports of manifest anxiety and symptoms of separation anxiety and overanxious disorders: a community-based twin study.

    abstract::Genetic and environmental influences in the determination of individual differences in self-reported symptoms of separation anxiety (SAD), overanxious disorder (OAD), and manifest anxiety (MANX) were evaluated in children and adolescents for three age groups (8-10, 11-13, and 14-16). Symptom counts for SAD and OAD wer...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1023/a:1025607107566

    authors: Topolski TD,Hewitt JK,Eaves LJ,Silberg JL,Meyer JM,Rutter M,Pickles A,Simonoff E

    更新日期:1997-01-01 00:00:00

  • Genetic influences on political ideologies: twin analyses of 19 measures of political ideologies from five democracies and genome-wide findings from three populations.

    abstract::Almost 40 years ago, evidence from large studies of adult twins and their relatives suggested that between 30 and 60% of the variance in social and political attitudes could be explained by genetic influences. However, these findings have not been widely accepted or incorporated into the dominant paradigms that explai...

    journal_title:Behavior genetics

    pub_type: 杂志文章,meta分析

    doi:10.1007/s10519-014-9648-8

    authors: Hatemi PK,Medland SE,Klemmensen R,Oskarsson S,Littvay L,Dawes CT,Verhulst B,McDermott R,Nørgaard AS,Klofstad CA,Christensen K,Johannesson M,Magnusson PK,Eaves LJ,Martin NG

    更新日期:2014-05-01 00:00:00

  • Applying Novel Methods for Assessing Individual- and Neighborhood-Level Social and Psychosocial Environment Interactions with Genetic Factors in the Prediction of Depressive Symptoms in the Multi-Ethnic Study of Atherosclerosis.

    abstract::Complex illnesses, like depression, are thought to arise from the interplay between psychosocial stressors and genetic predispositions. Approaches that take into account both personal and neighborhood factors and that consider gene regions as well as individual SNPs may be necessary to capture these interactions acros...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-015-9734-6

    authors: Ware EB,Smith JA,Mukherjee B,Lee S,Kardia SL,Diez-Roux AV

    更新日期:2016-01-01 00:00:00

  • Differential genetic etiology of reading component processes as a function of IQ.

    abstract::Results obtained from previous studies of word recognition, reading component skills, and reading composite measures suggest that genetic factors may be more important as a cause for reading disability among children with higher IQ scores than among those with lower IQ scores. To investigate the genetic etiology of re...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1023/a:1016069012111

    authors: Knopik VS,Smith SD,Cardon L,Pennington B,Gayan J,Olson RK,DeFries JC

    更新日期:2002-05-01 00:00:00

  • Correlated response in selection for aggressiveness in female mice. I. Male aggressiveness.

    abstract::Males from the fifty selected generation of a selection program for aggressiveness in female Mus musculus (Ebert and Hyde, 1976) were tested to determine whether male aggressiveness showed a correlated response in selection for female aggressiveness. The results indicated that male aggression had not shown a correlate...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/BF01065699

    authors: Hyde JS,Ebert PD

    更新日期:1976-10-01 00:00:00

  • Oligogenic determination of morphine analgesic magnitude: a genetic analysis of selectively bred mouse lines.

    abstract::Two ongoing selective breeding projects have produced mice that display divergent analgesic responses to morphine. These two projects have selected for similar phenotypes: high and low levorphanol analgesia (HAR/LAR lines; Portland, OR) and high and low swim stress-induced analgesia (HA/LA lines; Jastrzebiec, Poland)....

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/BF02197290

    authors: Mogil JS,Flodman P,Spence MA,Sternberg WF,Kest B,Sadowski B,Liebeskind JC,Belknap JK

    更新日期:1995-07-01 00:00:00

  • Quantitative trait loci associated with reversal learning and latent inhibition in honeybees (Apis mellifera).

    abstract::A study was conducted to identify quantitative trait loci (QTLs) that affect learning in honeybees. Two F1 supersister queens were produced from a cross between two established lines that had been selected for differences in the speed at which they reverse a learned discrimination between odors. Different families of ...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1023/a:1012227308783

    authors: Chandra SB,Hunt GJ,Cobey S,Smith BH

    更新日期:2001-05-01 00:00:00

  • Social aggregations in cattle. I. Segregation by breed in free-ranging herds.

    abstract::Social aggregations of free-ranging cattle were studied in the Sonoran Desert of Mexico. Cows reared with animals of their own breed in isolation from other breeds maintained segregated social groups. Cows raised together in a mixed herd containing other breeds allied themselves with herd-mates regardless of breed. Ca...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/BF01065562

    authors: Murphey RM

    更新日期:1990-05-01 00:00:00

  • Bayesian composite model space approach for mapping quantitative trait Loci in variance component model.

    abstract::In this article, we successfully apply the novel model selection method, Bayesian composite model space approach which has been used to map quantitative trait loci (QTL) for allelic substitution model, to map QTL for variance component model. The novel model selection approach has two advantages compared to the revers...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-009-9259-y

    authors: Fang M,Liu S,Jiang D

    更新日期:2009-05-01 00:00:00

  • Activity rhythms in inbred mice. I. Genetic analysis with recombinant inbred strains.

    abstract::Rhythm of activity of inbred mice was recorded automatically by a set of actographs. This rhythm was characterized by six indices in the temporal and frequency domains. Two methods of genetic analysis were applied to these indices using parental strains BALB/c and C57BL/6, the reciprocal F1's, and the seven recombinan...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/BF01066331

    authors: Beau J

    更新日期:1991-03-01 00:00:00

  • Multivariate genetic analysis of chronic pelvic pain and associated phenotypes.

    abstract::Chronic pelvic pain (CPP) is a common condition in women that is difficult to diagnose. Although heritability estimates have been published for some conditions potentially underlying pelvic pain, the heritability of CPP itself has never been investigated. Using data from 623 MZ and 377 DZ female twin pairs aged 29-50 ...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-004-1017-6

    authors: Zondervan KT,Cardon LR,Kennedy SH,Martin NG,Treloar SA

    更新日期:2005-03-01 00:00:00

  • Congenic mouse strains enable discrimination of genetic determinants contributing to fear and fear memory.

    abstract::The ability to learn and remember is variable within a population of a given species, including humans. This is due in part to genetic variation between individuals. However, only few genes have been identified that contribute to variation in learning and memory. Two inbred mouse strains, C57Bl/6J (B6) and DBA/2J (D2)...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-010-9387-4

    authors: Wilson YM,Brodnicki TC,Lawrence AJ,Murphy M

    更新日期:2011-03-01 00:00:00

  • Evidence for genetic influences on human energy intake: results from a twin study using measured observations.

    abstract::Human obesity is associated with greater-than-average energy intake, although relatively few studies have tested the heritability of food intake. The present study examined the genetic architecture of measured caloric intake during laboratory test meals in 36 monozygotic and 18 dizygotic twin pairs. A series of analys...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1023/a:1021683716700

    authors: Faith MS,Rha SS,Neale MC,Allison DB

    更新日期:1999-05-01 00:00:00

  • Using shared and unique parental views to study the etiology of 7-year-old twins' internalizing and externalizing problems.

    abstract::In a sample of 1,940 Dutch 7-year-old twin pairs we studied the etiology of individual differences in Internalizing and Externalizing behavioral problems. For the majority of twins in the sample, both maternal and paternal ratings of behavioral problems were obtained from the Child Behavior Checklist. This made it pos...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1023/a:1025369525924

    authors: van der Valk JC,van den Oord EJ,Verhulst FC,Boomsma DI

    更新日期:2003-07-01 00:00:00

  • Antipredator behavior in paradise fish (Macropodus opercularis) larvae: the role of genetic factors and paternal influence.

    abstract::The paradise fish, a small insectivore, coinhabits marshes of Southeast Asia with several predator fish species. Its ability to recognize and avoid harmful fish may depend upon both genetic factors and experience. Here we demonstrate genetic variability between the 20-day-old larvae of two inbred strains of paradise f...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1023/a:1025601828464

    authors: Miklósi A,Csányi V,Gerlai R

    更新日期:1997-05-01 00:00:00

  • Hormonal and neurotransmitter regulation of GnRH gene expression and related reproductive behaviors.

    abstract::Gonadotropin-releasing hormone (GnRH), having a highly conserved structure across mammalian species, plays a pivotal role in the control of the neuroendocrine events and the inherent sexual behaviors essential for reproductive function. Recent advances in molecular genetic technology have contributed greatly to the in...

    journal_title:Behavior genetics

    pub_type: 杂志文章,评审

    doi:10.1007/BF02359383

    authors: Sagrillo CA,Grattan DR,McCarthy MM,Selmanoff M

    更新日期:1996-05-01 00:00:00

  • Likelihood-based analyses of longitudinal twin and family data: experiences with pedigree-based approaches.

    abstract::Substantial progress has been made recently in analyses of longitudinal twin and family data, principally for two reasons. The first is the continuing development of more refined models for describing longitudinal data; the second is the widespread availability of analytic methods (e.g. LISREL) with which to implement...

    journal_title:Behavior genetics

    pub_type: 评论,杂志文章

    doi:10.1007/BF01067000

    authors: Williams CJ,Viken R,Rose RJ

    更新日期:1992-03-01 00:00:00

  • Quantile-Specific Heritability of Intakes of Alcohol but not Other Macronutrients.

    abstract::Genetic heritability (h2) of alcohol use is reported to be greater in rural dwellers, distressed marriages, low socioeconomic status, in girls who are unmarried or lacking closeness with their parents or religious upbringing, in less-educated men, and in adolescents with peers using alcohol. However, these are all ris...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-020-10005-z

    authors: Williams PT

    更新日期:2020-09-01 00:00:00

  • Short-Term Genetic Selection for Adolescent Locomotor Sensitivity to Delta9-Tetrahydrocannabinol (THC).

    abstract::Cannabis use is linked to positive and negative outcomes. Identifying genetic targets of susceptibility to the negative effects of cannabinoid use is of growing importance. The current study sought to complete short-term selective breeding for adolescent sensitivity and resistance to the locomotor effects of a single ...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-018-9894-2

    authors: Kasten CR,Zhang Y,Mackie K,Boehm SL 2nd

    更新日期:2018-05-01 00:00:00

  • Relationship between brain and cognitive processes in Down syndrome.

    abstract::We investigated regional grey matter (GM) density in adolescents with Down syndrome (DS) compared to age-matched controls and correlated MRI data with neuropsychological measures in the DS group. Inter-group comparisons documented several GM concentration abnormalities in the participants with DS compared to controls....

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-011-9448-3

    authors: Menghini D,Costanzo F,Vicari S

    更新日期:2011-05-01 00:00:00

  • Genetic differences in learning behavior in honeybees (Apis mellifera capensis).

    abstract::Workers from colonies of Cape honeybees show marked phenotypic differences in performance in proboscis extension reflex (PER) conditioning. Analysis of these differences using parthenogenetic offspring groups permitted the estimation of genotypic values and revealed a high degree of genetic variability that is evident...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/BF01065820

    authors: Brandes C

    更新日期:1991-05-01 00:00:00

  • Selection for agonistic behavior in wild female mice.

    abstract::This article reports the results of 11 generations of selective breeding for isolation-induced, interfemale aggression in Mus musculus. Within-family selection was used to form two high, two low, and two unselected control lines, beginning with a population of wild-trapped mice. Selection was successful in establishin...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/BF01065597

    authors: Hyde JS,Sawyer TF

    更新日期:1980-07-01 00:00:00

  • Genetics of Interactive Behavior in Silver Foxes (Vulpes vulpes).

    abstract::Individuals involved in a social interaction exhibit different behavioral traits that, in combination, form the individual's behavioral responses. Selectively bred strains of silver foxes (Vulpes vulpes) demonstrate markedly different behaviors in their response to humans. To identify the genetic basis of these behavi...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-016-9815-1

    authors: Nelson RM,Temnykh SV,Johnson JL,Kharlamova AV,Vladimirova AV,Gulevich RG,Shepeleva DV,Oskina IN,Acland GM,Rönnegård L,Trut LN,Carlborg Ö,Kukekova AV

    更新日期:2017-01-01 00:00:00

  • Mixed-effects variance components models for biometric family analyses.

    abstract::Recent substantive research on biometric analyses of twin and family data has used both a biometric path analysis model (PAM) and a biometric variance components model (VCM). Methodological research on these same topics have suggested benefits of using linear structural equation model algorithms (SEMA) as well as mixe...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-005-2868-1

    authors: McArdle JJ,Prescott CA

    更新日期:2005-09-01 00:00:00

  • Marriage and genetic variation across the lifespan: not a steady relationship?

    abstract::The prevalence of marriage varies across the lifespan, as does its importance to reproduction and the nurturance of children. We examined genetic and environmental influences on self-reported marriage at each decade from 20 through 70 years of age, using data collected for the Duke Dementia Study, a followed-up subset...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-006-9132-1

    authors: Trumbetta SL,Markowitz EM,Gottesman II

    更新日期:2007-03-01 00:00:00

  • Resemblances of parents and twins in sports participation and heart rate.

    abstract::A model to analyze resemblances of twins and parents using LISREL is outlined and applied to sports participation and heart-rate data. Sports participation and heart rate were measured in 44 monozygotic and 46 dizygotic adolescent twin pairs and in their parents. Genetic factors influence variation in both sports beha...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/BF01065888

    authors: Boomsma DI,van den Bree MB,Orlebeke JF,Molenaar PC

    更新日期:1989-01-01 00:00:00

  • A quantitative genetic analysis of locomotor activity in CXB recombinant inbred mice.

    abstract::Recent studies have identified genes that influence the length of the circadian period maintained by mice housed under constant lighting conditions. However, a less studied circadian activity variable is the amplitude of daily oscillations in locomotor activity. This parameter reflects spontaneous activity exhibited u...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1023/a:1021657800287

    authors: Toth LA,Williams RW

    更新日期:1999-09-01 00:00:00

  • Assortative mating in Drosophila adapted to a microsite ecological gradient.

    abstract::Elucidating the causes of population divergence, and ultimately speciation, is a central objective of evolutionary biology. A number of previous studies of Drosophila populations from the Nahal Oren canyon (Mt Carmel, Israel) revealed significant interslope differences for a complex of fitness and behavioral traits. P...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-005-6119-2

    authors: Singh SR,Rashkovetsky E,Iliadi K,Nevo E,Korol A

    更新日期:2005-11-01 00:00:00

  • Genetic and environmental influences on depressive symptoms in Chinese adolescents.

    abstract::Adolescent depression is common and has become a major public health concern in China, yet little research has examined the etiology of depression in Chinese adolescents. In the present study, genetic and environmental influences on Chinese adolescent depressive symptoms were investigated in 1,181 twin pairs residing ...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-013-9632-8

    authors: Chen J,Li X,Natsuaki MN,Leve LD,Harold GT

    更新日期:2014-01-01 00:00:00

  • Do schools moderate the genetic determinants of smoking?

    abstract::This paper uses data from the National Longitudinal Study of Adolescent Health to examine the extent to which school-level social and institutional factors moderate genetic tendencies to smoke cigarettes. Our analysis relies on a sub-sample of 1,198 sibling and twin pairs nested within 84 schools. We develop a multile...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-008-9197-0

    authors: Boardman JD,Saint Onge JM,Haberstick BC,Timberlake DS,Hewitt JK

    更新日期:2008-05-01 00:00:00