Abstract：
:Complex illnesses, like depression, are thought to arise from the interplay between psychosocial stressors and genetic predispositions. Approaches that take into account both personal and neighborhood factors and that consider gene regions as well as individual SNPs may be necessary to capture these interactions across race and ethnic groups. We used novel gene-region based analysis methods [Sequence Kernel Association Test (SKAT) and meta-analysis (MetaSKAT), gene-environment set association test (GESAT)], as well as traditional linear models to identify gene region and SNP × psychosocial factor interactions at the individual- and neighborhood-level, across multiple race/ethnicities. Multiple regions identified in SKAT analyses showed evidence of a significant gene-region association with averaged depressive symptom scores across race/ethnicity (MetaSKAT p values <0.001). One region × neighborhood-environment interaction was significantly associated with averaged depressive symptom score across race/ethnicity after multiple testing correction (chr 18:21454070-21494070, Fisher's combined p value = 0.001). The examination of gene regions jointly with environmental factors measured at multiple levels (individuals and their contexts) may shed light on the etiology of depressive illness across race/ethnicities.
journal_name
Behav Genetjournal_title
Behavior geneticsauthors
Ware EB,Smith JA,Mukherjee B,Lee S,Kardia SL,Diez-Roux AVdoi
10.1007/s10519-015-9734-6subject
Has Abstractpub_date
2016-01-01 00:00:00pages
89-99issue
1eissn
0001-8244issn
1573-3297pii
10.1007/s10519-015-9734-6journal_volume
46pub_type
杂志文章abstract：:This paper uses data from the National Longitudinal Study of Adolescent Health to examine the extent to which school-level social and institutional factors moderate genetic tendencies to smoke cigarettes. Our analysis relies on a sub-sample of 1,198 sibling and twin pairs nested within 84 schools. We develop a multile...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-008-9197-0
更新日期：2008-05-01 00:00:00
abstract：:Adolescent depression is common and has become a major public health concern in China, yet little research has examined the etiology of depression in Chinese adolescents. In the present study, genetic and environmental influences on Chinese adolescent depressive symptoms were investigated in 1,181 twin pairs residing ...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-013-9632-8
更新日期：2014-01-01 00:00:00
abstract：:We investigated the extent to which performance on standardized achievement tests, executive function (EF), and aggression in childhood and adolescence accounted for the relationship between a polygenic score for educational attainment (EA PGS) and years of education in a community sample of African Americans. Partici...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-019-09982-7
更新日期：2020-01-01 00:00:00
abstract：:Genetic strains of mice represent an important resource for research on the biological determinants of complex diseases and behavioral phenotypes. To date, the approaches used have had little success in identifying causal genes. We have evaluated brain gene expression in C57BL/6J (B6) and DBA/2J (D2) inbred mouse stra...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/B:BEGE.0000023648.78190.ee
更新日期：2004-07-01 00:00:00
abstract：:Human facial attractiveness and facial sexual dimorphism (masculinity-femininity) are important facets of mate choice and are hypothesized to honestly advertise genetic quality. However, it is unclear whether genes influencing facial attractiveness and masculinity-femininity have similar, opposing, or independent effe...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-013-9627-5
更新日期：2014-05-01 00:00:00
abstract：:Previously, sequence variation in the glucocorticoid (GR) and mineralocorticoid (MR) receptor genes (NR3C1 and NR3C2, respectively) have been found to be associated with physiological stress responses to social stress tests in small samples of adult men and oral contraceptives (OC) using women. Associations between si...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-010-9385-6
更新日期：2011-03-01 00:00:00
abstract：:Using high resolution magnetic resonance imaging data, we examined the interrelationships between eight cerebral lobar volumetric measures via both exploratory and confirmatory factor analyses in a large sample (N = 484) of pediatric twins and singletons. These analyses suggest the presence of strong genetic correlati...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-010-9332-6
更新日期：2010-03-01 00:00:00
abstract：:We examined data from a large cohort of homosexual and heterosexual females and males concerning their siblings' sexual orientations. As in previous studies, both male and female homosexuality were familial. Homosexual females had an excess of homosexual brothers compared to heterosexual subjects, thus providing evide...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01067431
更新日期：1993-07-01 00:00:00
abstract：:Gender-moderated gene-environment interactions are rarely explored, raising concerns about inaccurate specification of etiological models and inferential errors. The current study examined the influence of gender, negative and positive daily life events, and GABRA2 genotype (SNP rs279871) on alcohol dependence, testin...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-013-9607-9
更新日期：2013-09-01 00:00:00
abstract：:The region containing ROBO1 (Chromosome 3p12.3) has been implicated as a susceptibility gene for reading disorder and language deficit by translocation and linkage data. No association studies have yet been reported supporting any candidate gene. Here we report the first association of this gene with language deficits...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-010-9402-9
更新日期：2011-01-01 00:00:00
abstract：:Genetic heritability (h2) of alcohol use is reported to be greater in rural dwellers, distressed marriages, low socioeconomic status, in girls who are unmarried or lacking closeness with their parents or religious upbringing, in less-educated men, and in adolescents with peers using alcohol. However, these are all ris...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-020-10005-z
更新日期：2020-09-01 00:00:00
abstract：:The role of non-shared environment (NSE) in the development of psychological traits is usually comparable with that of the genotype. However, no specific factors of NSE with significant impact on such traits have been discovered so far. We propose that the current failures in understanding the origin of NSE are at lea...
journal_title：Behavior genetics
pub_type： 杂志文章,评审
doi：10.1007/s10519-019-09950-1
更新日期：2019-05-01 00:00:00
abstract：:Components of the communication system between infant and adult rodents based on ultrasonic vocalizations (USVs) of infants are analyzed. USVs are most often emitted from a pup lost outside the nest in response to changes of: (i) body temperature, (ii) contact with adults/littermates, (iii) handling, and (iv) smell. T...
journal_title：Behavior genetics
pub_type： 杂志文章,评审
doi：10.1007/s10519-004-0853-8
更新日期：2005-01-01 00:00:00
abstract：:In the original version of this article, unfortunately, in the acknowledgement section "National Institutes of Health (NIH, R37 AG033590-08) to J Cacioppo" was omitted. This has been corrected by publishing this erratum. ...
journal_title：Behavior genetics
pub_type： 已发布勘误
doi：10.1007/s10519-019-09956-9
更新日期：2019-05-01 00:00:00
abstract：:Most research on child behavior incorporates information from different individuals. While agreement between informants is generally only modest, there is little understanding of the processes underlying disagreement. In twin studies, differential agreement among raters for MZ and DZ twins is of particular concern. Th...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF02197280
更新日期：1995-07-01 00:00:00
abstract：:In previous electrophysiological experiments from hypopigmented animals (mice, rats, rabbits), single-unit recordings from both retinal ganglion axons and cells in the superior colliculus have demonstrated an increase in threshold in the dark-adapted state which is roughly proportional to the ocular melanin concentrat...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01067442
更新日期：1993-07-01 00:00:00
abstract：:Age-related changes are analyzed in the correlation of 3416 monozygotic and 3780 dizygotic U.S. twin pairs aged between 9 and 75+ years for conservatism scores derived from a 28-item social attitude inventory. The effects of the shared environment are overwhelming in twins aged 20 years or younger. In older twins, gen...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/a:1025633307992
更新日期：1997-03-01 00:00:00
abstract：:Tested in Hirsch-Hadler mazes, Drosophila pseudoobscura is on the average geoneutral and photoneutral. Strongly geo- and photopositive and geo- and photonegative populations can be obtained by artificial selection, but upon relaxation of the selection they tend to relapse toward neutrality. This genetic homeostasis is...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01065728
更新日期：1976-07-01 00:00:00
abstract：:Genetic and environmental influences on problem behaviors were studied in a sample of international adoptees. Parental ratings of childrens' problem behaviors were obtained with the Child Behavior Checklist (CBCL). The sample (mean age, 12.4 years) comprised a group of biological siblings (111 pairs), a group of nonbi...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01067187
更新日期：1994-05-01 00:00:00
abstract：:Chickens homozygous for the Dominant white or wild-type allele of PMEL17 were subjected to a broad phenotyping in order to detect consistent differences between genotypes. To exclude feather pecking, the chickens were individually housed without physical contact, from the day of hatching, and tested for social, aggres...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-010-9379-4
更新日期：2011-03-01 00:00:00
abstract：:Heterozygous staggerer mice (Rora(+)/Rora(sg)) and control mice (Rora(+)/Rora(+)) of the same C57BL/6J strain background were tested in a spontaneous alternation task at 3 to 24 months old. The results demonstrated a decrement in long-term working memory as early as 6 months in Rora(+)/Rora(+) mice and at 3 months in ...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/B:BEGE.0000017875.78571.a6
更新日期：2004-05-01 00:00:00
abstract：:As a result of different feeding regimens, two laboratory populations of the beetle Callosobruchus maculatus Fab. developed different rates of oviposition. The behavior of the F1 hybrids cannot be explained with an additive model of inheritance. The unusual pattern of inheritance suggests a sex-related factor(s) and a...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01065625
更新日期：1981-03-01 00:00:00
abstract：:The attempt to characterize high- and low-selected lines on new variables poses serious interpretative problems when replicate lines are not available. Modest but significant line differences on new measures may be due to genetic drift totally irrelevant to the originally selected trait. Often these differences are ex...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01066250
更新日期：1989-07-01 00:00:00
abstract：:Selective breeding for initial sensitivity to ethanol has been carried out by a number of investigators in order to investigate the mechanisms by which ethanol brings about a myriad of effects on the mammalian central nervous system. In addition the availability of these selectively bred animals provides clues to the ...
journal_title：Behavior genetics
pub_type： 杂志文章,评审
doi：10.1007/BF01067420
更新日期：1993-03-01 00:00:00
abstract：:Extreme sampling of sibling pairs has been shown to be efficient in terms of statistical power and sample sizes (in number of sibling pairs needed to genotype) to detect a quantitative trait locus (QTL) when the residual distribution is normal. In the present study, the efficiency of extreme sampling strategies to det...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/a:1014403827957
更新日期：2002-01-01 00:00:00
abstract：:Callous-unemotional (CU) traits comprise the core symptoms of psychopathy, yet no study has estimated the heritability of CU traits in a community sample of children using an instrument designed solely to assess CU traits. The current study uses data from 339 twin pairs aged 9-14 to examine the reliability and heritab...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-016-9831-1
更新日期：2017-03-01 00:00:00
abstract：:A model based on the latent class model is developed for the effects of genes and environment on multivariate categorical data in twins. The model captures many essential features of dimensional and categorical conceptions of complex behavioral phenotypes and can include, as special cases, a variety of major locus mod...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01067550
更新日期：1993-01-01 00:00:00
abstract：:We present a repeated-measures, genetic analysis of ethanol-induced anesthesia (sleep time) in mice from the inbred long-sleep (ILS) and short-sleep (ISS) strains of mice and their derived F1 and F2 generations. Mice (total N > 1300) were administered a 4.1 g/kg intraperitoneal dose of ethanol at two times, 7 to 10 da...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF02197243
更新日期：1995-01-01 00:00:00
abstract：:Recent studies have identified genes that influence the length of the circadian period maintained by mice housed under constant lighting conditions. However, a less studied circadian activity variable is the amplitude of daily oscillations in locomotor activity. This parameter reflects spontaneous activity exhibited u...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/a:1021657800287
更新日期：1999-09-01 00:00:00
abstract：:Sixty-six mice of 11 genetic stocks (the Bailey recombinant inbred strains CXBD, CXBE, CXBG, CXBH, CXBI, CXBJ, CXBK; their progenitor strains, BALB/cBy and C57BL/6By: and the reciprocal hybrids, B6CF and CB6F) were tested in a two-compartment apparatus and in a shuttlebox, with five measures taken relating to activity...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01066277
更新日期：1977-05-01 00:00:00
