Pathways Between a Polygenic Score for Educational Attainment and Higher Educational Attainment in an African American Sample.

Abstract:

:We investigated the extent to which performance on standardized achievement tests, executive function (EF), and aggression in childhood and adolescence accounted for the relationship between a polygenic score for educational attainment (EA PGS) and years of education in a community sample of African Americans. Participants (N = 402; 49.9% female) were initially recruited for an elementary school-based prevention trial in a Mid-Atlantic city and followed into adulthood. In first and twelfth grade, participants completed math and reading standardized tests and teachers reported on participants' aggression and EF, specifically impulsivity and concentration problems. At age 20, participants reported on their years of education and post-secondary degrees attained and their genotype was assayed from blood or buccal swabs. An EA PGS was created using results from a large-scale GWAS on EA. A higher EA PGS was associated with higher education indirectly via adolescent achievement. No other mediating mechanisms were significant. Adolescent academic achievement is thus one mechanism through which polygenic propensity for EA influences post-secondary education among urban, African American youth.

journal_name

Behav Genet

journal_title

Behavior genetics

authors

Rabinowitz JA,Kuo SI,Domingue B,Smart M,Felder W,Benke K,Maher BS,Ialongo NS,Uhl G

doi

10.1007/s10519-019-09982-7

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

14-25

issue

1

eissn

0001-8244

issn

1573-3297

pii

10.1007/s10519-019-09982-7

journal_volume

50

pub_type

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