Genome-wide scan of IQ finds significant linkage to a quantitative trait locus on 2q.

Abstract:

:A genome-wide linkage scan of 795 microsatellite markers (761 autosomal, 34 X chromosome) was performed on Multidimensional Aptitude Battery subtests and verbal, performance and full scale scores, the WAIS-R Digit Symbol subtest, and two word-recognition tests (Schonell Graded Word Reading Test, Cambridge Contextual Reading Test) highly predictive of IQ. The sample included 361 families comprising 2-5 siblings who ranged in age from 15.7 to 22.2 years; genotype, but not phenotype, data were available for 81% of parents. A variance components analysis which controlled for age and sex effects showed significant linkage for the Cambridge reading test and performance IQ to the same region on chromosome 2, with respective LOD scores of 4.15 and 3.68. Suggestive linkage (LOD score>2.2) for various measures was further supported on chromosomes 6, 7, 11, 14, 21 and 22. Where location of linkage peaks converged for IQ subtests within the same scale, the overall scale score provided increased evidence for linkage to that region over any individual subtest. Association studies of candidate genes, particularly those involved in neural transmission and development, will be directed to genes located under the linkage peaks identified in this study.

journal_name

Behav Genet

journal_title

Behavior genetics

authors

Luciano M,Wright MJ,Duffy DL,Wainwright MA,Zhu G,Evans DM,Geffen GM,Montgomery GW,Martin NG

doi

10.1007/s10519-005-9003-1

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

45-55

issue

1

eissn

0001-8244

issn

1573-3297

journal_volume

36

pub_type

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