Abstract:
:A genome-wide linkage scan of 795 microsatellite markers (761 autosomal, 34 X chromosome) was performed on Multidimensional Aptitude Battery subtests and verbal, performance and full scale scores, the WAIS-R Digit Symbol subtest, and two word-recognition tests (Schonell Graded Word Reading Test, Cambridge Contextual Reading Test) highly predictive of IQ. The sample included 361 families comprising 2-5 siblings who ranged in age from 15.7 to 22.2 years; genotype, but not phenotype, data were available for 81% of parents. A variance components analysis which controlled for age and sex effects showed significant linkage for the Cambridge reading test and performance IQ to the same region on chromosome 2, with respective LOD scores of 4.15 and 3.68. Suggestive linkage (LOD score>2.2) for various measures was further supported on chromosomes 6, 7, 11, 14, 21 and 22. Where location of linkage peaks converged for IQ subtests within the same scale, the overall scale score provided increased evidence for linkage to that region over any individual subtest. Association studies of candidate genes, particularly those involved in neural transmission and development, will be directed to genes located under the linkage peaks identified in this study.
journal_name
Behav Genetjournal_title
Behavior geneticsauthors
Luciano M,Wright MJ,Duffy DL,Wainwright MA,Zhu G,Evans DM,Geffen GM,Montgomery GW,Martin NGdoi
10.1007/s10519-005-9003-1subject
Has Abstractpub_date
2006-01-01 00:00:00pages
45-55issue
1eissn
0001-8244issn
1573-3297journal_volume
36pub_type
杂志文章abstract::Our genetic knowledge of a species is reflected in the state of its gene map. Although still primitive, relative to the gene map of the mouse, great strides have been made in recent years in developing the gene map of the rat and nine linkage groups have now been defined. Mapping by conventional backcrossing methods h...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01070002
更新日期:1981-09-01 00:00:00
abstract::This note reports data on parent-child and spouse resemblance on the Wechsler intelligence scales, the WISC and WAIS. Test data on parents and one male 10-year-old child from 55 Canadian families are used to estimate father-son, mother-son, midparent-son, and father-mother correlations on 11 comparable subscales and o...
journal_title:Behavior genetics
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doi:10.1007/BF01073209
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01076179
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abstract::Data from two twin studies were used to address two related questions. First, is there any association between handedness and specific speech and language impairment (SSLI) in children? Second, is there genetic influence on individual differences in handedness and, if so, are the same genes implicated in the cause of ...
journal_title:Behavior genetics
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doi:10.1023/a:1012239617367
更新日期:2001-07-01 00:00:00
abstract::Current behavior genetic models can only employ limited types of phenotypic data, such as Likert scale data or continuous data, as variables. Here, a new method employing paired comparison data is presented within the framework of behavior genetic models. This model facilitates the estimation of genetic, shared enviro...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-007-9183-y
更新日期:2008-03-01 00:00:00
abstract::Cannabis use is linked to positive and negative outcomes. Identifying genetic targets of susceptibility to the negative effects of cannabinoid use is of growing importance. The current study sought to complete short-term selective breeding for adolescent sensitivity and resistance to the locomotor effects of a single ...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-018-9894-2
更新日期:2018-05-01 00:00:00
abstract::Rhythm of activity of inbred mice was recorded automatically by a set of actographs. This rhythm was characterized by six indices in the temporal and frequency domains. Two methods of genetic analysis were applied to these indices using parental strains BALB/c and C57BL/6, the reciprocal F1's, and the seven recombinan...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01066331
更新日期:1991-03-01 00:00:00
abstract::Elucidating the causes of population divergence, and ultimately speciation, is a central objective of evolutionary biology. A number of previous studies of Drosophila populations from the Nahal Oren canyon (Mt Carmel, Israel) revealed significant interslope differences for a complex of fitness and behavioral traits. P...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-005-6119-2
更新日期:2005-11-01 00:00:00
abstract::A central issue in psychiatric genetics is whether positive findings replicate. Zubenko et al. (2002b, Mol. Psychiatry 7:460-467) reported an association of the 124-bp allele of D2S2944 with recurrent early-onset major depression for females. We tested for association of this allele to continuous measures of anxiety, ...
journal_title:Behavior genetics
pub_type: 杂志文章,多中心研究
doi:10.1007/s10519-005-9006-y
更新日期:2006-01-01 00:00:00
abstract::It is well established that many continuously distributed traits have a heritable component. However, it is often difficult to communicate to the general public the meaning of quantitative estimates of heritability. To address this problem, the present paper introduces a heuristic for communicating heritability to non...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/a:1025670316169
更新日期:1997-09-01 00:00:00
abstract::The most common alternative to a genetic explanation of left-handedness is that sinistrality arises because of birth stress factors. In a sample of 1398 subjects, the association between birth stress and left-handedness was confirmed. More importantly, it was found that left-handed mothers are more likely to have birt...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF02327575
更新日期:1995-11-01 00:00:00
abstract::Sex differences in genetic and environmental influences on criminal behavior against property were studied in a birth cohort of 6129 male and 7065 female Danish adoptees and their biological and adoptive parents. Both genetic and environmental factors were found to contribute to variation in liability to property crim...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01066164
更新日期:1989-05-01 00:00:00
abstract::For many psychiatric conditions it is speculated that, rather than being single disease entities, they are a set of several disorders sharing clinical features but having (partly) different underlying causes. The possibility of measuring genetic variation on a large scale has given researchers new hope of identifying ...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-006-9135-y
更新日期:2007-05-01 00:00:00
abstract::Male Drosophila melanogaster from lines artificially selected to have divergent life histories were tested to determine if they differed in their effects on female reproductive behavior. During the first 5 days after mating, males from short-generation populations caused females to lay eggs at a faster rate than did m...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF02361157
更新日期:1996-01-01 00:00:00
abstract::: We report heritabilities for individual differences in female pubertal development at the age of 12. Tanner data on breast and pubic hair development in girls and data on menarche were obtained from a total of 184 pairs of monozygotic and dizygotic twins. Genetic correlations were estimated to determine to what exte...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-005-9022-y
更新日期:2006-03-01 00:00:00
abstract::Testis specific protein, Y-encoded-like 2 (TSPYL2) regulates the expression of genes encoding glutamate receptors. Glutamate pathology is implicated in neurodevelopmental conditions such as autism spectrum disorder, attention deficit hyperactivity disorder (ADHD) and schizophrenia. In line with this, a microduplicatio...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-015-9777-8
更新日期:2016-07-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-019-09982-7
更新日期:2020-01-01 00:00:00
abstract::The attempt to characterize high- and low-selected lines on new variables poses serious interpretative problems when replicate lines are not available. Modest but significant line differences on new measures may be due to genetic drift totally irrelevant to the originally selected trait. Often these differences are ex...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01066250
更新日期:1989-07-01 00:00:00
abstract::Results obtained from previous studies of word recognition, reading component skills, and reading composite measures suggest that genetic factors may be more important as a cause for reading disability among children with higher IQ scores than among those with lower IQ scores. To investigate the genetic etiology of re...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/a:1016069012111
更新日期:2002-05-01 00:00:00
abstract::In studies of child psychopathology, phenotypes of interest are often obtained by parental ratings. When behavioral ratings are obtained in the context of a twin study, this allows for the decomposition of the phenotypic variance, into a genetic and a non-genetic part. If a phenotype is assessed by a single rater, her...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-016-9823-1
更新日期:2017-03-01 00:00:00
abstract::In previous electrophysiological experiments from hypopigmented animals (mice, rats, rabbits), single-unit recordings from both retinal ganglion axons and cells in the superior colliculus have demonstrated an increase in threshold in the dark-adapted state which is roughly proportional to the ocular melanin concentrat...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01067442
更新日期:1993-07-01 00:00:00
abstract::The transmission of social attitudes has been investigated as a possible model of cultural inheritance in a sample of 3810 twin pairs from the Australian National Health and Medical Research Twin Registry. Six social attitude factors were identified and univariate genetic models fitted to scores on each factor. A join...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01066792
更新日期:1992-01-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/a:1021494023660
更新日期:1999-01-01 00:00:00
abstract::The behaviors of male mice of the C57BL/6J (C57), CBA/Lac (CBA) and BALB/c (BALB) strains have been studied in the plus-maze and open field tests for estimation of state anxiety in the stressful novel conditions, and in the cubic box test (exploration of novel cubic box) and the partition test (behavioral reactivity t...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/a:1001999020138
更新日期:2000-03-01 00:00:00
abstract::Social aggregations of free-ranging cattle were studied in the Sonoran Desert of Mexico. Cows reared with animals of their own breed in isolation from other breeds maintained segregated social groups. Cows raised together in a mixed herd containing other breeds allied themselves with herd-mates regardless of breed. Ca...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01065562
更新日期:1990-05-01 00:00:00
abstract::Anxiety disorders are phenotypically complex and may involve multiple genetic influences on many neurotransmitter systems. Rodent tests used to investigate genetic influences on anxiety-like phenotypes have face and predictive validity as models for anxiety in humans. If multiple genes contribute additively to a trait...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/B:BEGE.0000009479.02183.1f
更新日期:2004-01-01 00:00:00
abstract::Feather pecking (FP) is a serious economic and welfare problem in the domestic fowl. It has recently been shown that the distribution of FP bouts within groups is heterogeneous and contains a sub-population of extreme feather peckers (EFP). The present study proposed a novel model to detect EFP hens. A mixture of two ...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-019-09971-w
更新日期:2020-01-01 00:00:00
abstract::Biometric studies have shown that happiness is strongly affected by genes. The findings are mainly based on twin data, however, and the full validity of the results has been debated. To overcome some limitations in classical twin research, we examined aetiological sources of subjective well-being (SWB), using two inde...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-010-9365-x
更新日期:2010-09-01 00:00:00
abstract::Selective breeding for initial sensitivity to ethanol has been carried out by a number of investigators in order to investigate the mechanisms by which ethanol brings about a myriad of effects on the mammalian central nervous system. In addition the availability of these selectively bred animals provides clues to the ...
journal_title:Behavior genetics
pub_type: 杂志文章,评审
doi:10.1007/BF01067420
更新日期:1993-03-01 00:00:00
abstract::Martin and Wilson (1982) describe two forms of sampling bias in twin studies. One is "hard selection," where individuals above a threshold participate, and those below do not. The second is "soft selection," where the probability of including a pair of relatives varies over the range of the character. We present an al...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01065901
更新日期:1989-03-01 00:00:00