An Extended Twin-Pedigree Study of Neuroticism in the Netherlands Twin Register.

Abstract:

:For the participants in the Netherlands Twin Register (NTR) we constructed the extended pedigrees which specify all relations among nuclear and larger twin families in the register. A total of 253,015 subjects from 58,645 families were linked to each other, to the degree that we had information on the relations among participants. We describe the algorithm that was applied to construct the pedigrees. For > 30,000 adolescent and adult NTR participants data were available on harmonized neuroticism scores. We analyzed these data in the Mendel software package (Lange et al., Bioinformatics 29(12):1568-1570, 2013) to estimate the contributions of additive and non-additive genetic factors. In contrast to much of the earlier work based on twin data rather than on extended pedigrees, we could also estimate the contribution of shared household effects in the presence of non-additive genetic factors. The estimated broad-sense heritability of neuroticism was 47%, with almost equal contributions of additive and non-additive (dominance) genetic factors. A shared household effect explained 13% and unique environmental factors explained the remaining 40% of the variance in neuroticism.

journal_name

Behav Genet

journal_title

Behavior genetics

authors

Boomsma DI,Helmer Q,Nieuwboer HA,Hottenga JJ,de Moor MH,van den Berg SM,Davies GE,Vink JM,Schouten MJ,Dolan CV,Willemsen G,Bartels M,van Beijsterveldt TCEM,Ligthart L,de Geus EJ

doi

10.1007/s10519-017-9872-0

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

1-11

issue

1

eissn

0001-8244

issn

1573-3297

pii

10.1007/s10519-017-9872-0

journal_volume

48

pub_type

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