Abstract:
:Structural equation modeling (SEM) provides a flexible tool to carry out genetic analyses of family and twin data. The basic model which decomposes the variance between and within families for a particular trait into genetic and non-genetic components can be generalized to multivariate and/or longitudinal data, incorporate sex differences in parameter estimates, and model the effects of measured environment, candidate genes or DNA marker data. We introduce a web-based library (http://www.psy.vu.nl/mxbib) of scripts for uni- and multivariate genetic epidemiological analyses, as well as for linkage and genetic association tests. The scripts are written to be used with the freely available software package Mx and provide a flexible and uniform approach to the analysis of data from relatives.
journal_name
Behav Genetjournal_title
Behavior geneticsauthors
Posthuma D,Boomsma DIdoi
10.1007/s10519-005-2791-5subject
Has Abstractpub_date
2005-07-01 00:00:00pages
499-505issue
4eissn
0001-8244issn
1573-3297journal_volume
35pub_type
杂志文章abstract::Heterozygous staggerer mice (Rora(+)/Rora(sg)) and control mice (Rora(+)/Rora(+)) of the same C57BL/6J strain background were tested in a spontaneous alternation task at 3 to 24 months old. The results demonstrated a decrement in long-term working memory as early as 6 months in Rora(+)/Rora(+) mice and at 3 months in ...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/B:BEGE.0000017875.78571.a6
更新日期:2004-05-01 00:00:00
abstract::For many psychiatric conditions it is speculated that, rather than being single disease entities, they are a set of several disorders sharing clinical features but having (partly) different underlying causes. The possibility of measuring genetic variation on a large scale has given researchers new hope of identifying ...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-006-9135-y
更新日期:2007-05-01 00:00:00
abstract::We investigated regional grey matter (GM) density in adolescents with Down syndrome (DS) compared to age-matched controls and correlated MRI data with neuropsychological measures in the DS group. Inter-group comparisons documented several GM concentration abnormalities in the participants with DS compared to controls....
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-011-9448-3
更新日期:2011-05-01 00:00:00
abstract::Heritability estimates of birth weight have been inconsistent. Possible explanations are heritability changes during gestational age or the influence of covariates (e.g. chorionicity). The aim of this study was to model birth weights of twins across gestational age and to quantify the genetic and environmental compone...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-007-9170-3
更新日期:2008-01-01 00:00:00
abstract::Effective mapping strategies for quantitative trains must allow for the detection of the more important quantitative trait loci (QTLs) while minimizing false positives. Type I (false-positive) and Type II (false-negative) error rates were estimated from a computer simulation of QTL mapping in the BXD recombinant inbre...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF02359892
更新日期:1996-03-01 00:00:00
abstract::The goal of the present study is to examine genetic and environmental influences on maternal and teacher ratings of Attention Problems (AP) in 7-year-old children. Teachers completed the Teacher Report Form (N=2259 pairs), and mothers the Child Behavior Checklist (N=2057 pairs). Higher correlations were found in twins...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-006-9084-5
更新日期:2006-11-01 00:00:00
abstract::Two ongoing selective breeding projects have produced mice that display divergent analgesic responses to morphine. These two projects have selected for similar phenotypes: high and low levorphanol analgesia (HAR/LAR lines; Portland, OR) and high and low swim stress-induced analgesia (HA/LA lines; Jastrzebiec, Poland)....
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF02197290
更新日期:1995-07-01 00:00:00
abstract::Age-related changes are analyzed in the correlation of 3416 monozygotic and 3780 dizygotic U.S. twin pairs aged between 9 and 75+ years for conservatism scores derived from a 28-item social attitude inventory. The effects of the shared environment are overwhelming in twins aged 20 years or younger. In older twins, gen...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/a:1025633307992
更新日期:1997-03-01 00:00:00
abstract::This study uses longitudinal population-based samples of young siblings to examine the effects of two hypothesized moderators of early externalizing behaviors: parental emotional support and family socioeconomic status. The first sample, a twin sample from the Early Childhood Longitudinal Study-Birth Cohort (ECLS-B), ...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-014-9664-8
更新日期:2014-09-01 00:00:00
abstract::Genome wide complex trait analysis (GCTA) is extended to include environmental effects of the maternal genotype on offspring phenotype ("maternal effects", M-GCTA). The model includes parameters for the direct effects of the offspring genotype, maternal effects and the covariance between direct and maternal effects. A...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-014-9666-6
更新日期:2014-09-01 00:00:00
abstract::We report analyses of data on body fat from a cohort of 34 separated monozygotic twin pairs (MZA) and a matched sample of 38 pairs of monozygotic twins reared together (MZT) originally studied by James Shields. The correlation for MZA pairs was .61 and the correlation for MZT pairs was .75. These correlations did not ...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01067662
更新日期:1991-01-01 00:00:00
abstract::The facts concerning Kammerer's case are reviewed. Koestler's view that Krammerer was unjustly accused is presented and shown to be incorrect. ...
journal_title:Behavior genetics
pub_type: 传,历史文章,杂志文章
doi:10.1007/BF01066805
更新日期:1975-04-01 00:00:00
abstract::Almost 40 years ago, evidence from large studies of adult twins and their relatives suggested that between 30 and 60% of the variance in social and political attitudes could be explained by genetic influences. However, these findings have not been widely accepted or incorporated into the dominant paradigms that explai...
journal_title:Behavior genetics
pub_type: 杂志文章,meta分析
doi:10.1007/s10519-014-9648-8
更新日期:2014-05-01 00:00:00
abstract::Reading ability and specific reading disability (SRD) are complex traits involving several cognitive processes and are shaped by a complex interplay of genetic and environmental forces. Linkage studies of these traits have identified several susceptibility loci. Association studies have gone further in detecting candi...
journal_title:Behavior genetics
pub_type: 杂志文章,评审
doi:10.1007/s10519-011-9444-7
更新日期:2011-01-01 00:00:00
abstract::Anxiety disorders are phenotypically complex and may involve multiple genetic influences on many neurotransmitter systems. Rodent tests used to investigate genetic influences on anxiety-like phenotypes have face and predictive validity as models for anxiety in humans. If multiple genes contribute additively to a trait...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/B:BEGE.0000009479.02183.1f
更新日期:2004-01-01 00:00:00
abstract::Inhibitory control (IC) is a dimension of child temperament that emerges in toddlerhood and involves the ability to regulate behavior in response to instructions or expectations. In general, children with low levels of IC have more cognitive and social difficulties, and higher levels of problem behaviors. Unfortunatel...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-009-9316-6
更新日期:2010-05-01 00:00:00
abstract::Cannabis use is linked to positive and negative outcomes. Identifying genetic targets of susceptibility to the negative effects of cannabinoid use is of growing importance. The current study sought to complete short-term selective breeding for adolescent sensitivity and resistance to the locomotor effects of a single ...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-018-9894-2
更新日期:2018-05-01 00:00:00
abstract::Human facial attractiveness and facial sexual dimorphism (masculinity-femininity) are important facets of mate choice and are hypothesized to honestly advertise genetic quality. However, it is unclear whether genes influencing facial attractiveness and masculinity-femininity have similar, opposing, or independent effe...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-013-9627-5
更新日期:2014-05-01 00:00:00
abstract::Common SNPs in nicotinic acetylcholine receptor genes (CHRN genes) have been associated with drug behaviors and personality traits, but the influence of rare genetic variants is not well characterized. The goal of this project was to identify novel rare variants in CHRN genes in the Center for Antisocial Drug Dependen...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-016-9792-4
更新日期:2016-09-01 00:00:00
abstract::Our genetic knowledge of a species is reflected in the state of its gene map. Although still primitive, relative to the gene map of the mouse, great strides have been made in recent years in developing the gene map of the rat and nine linkage groups have now been defined. Mapping by conventional backcrossing methods h...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01070002
更新日期:1981-09-01 00:00:00
abstract::A powerful longitudinal data source, the National Longitudinal Survey of Youth Children data, allows measurement of behavior problems (BP) within a developmental perspective linking them to menarcheal timing (MT). In a preliminary analysis, we evaluate the bivariate relationships between BP measured at different devel...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-014-9676-4
更新日期:2015-01-01 00:00:00
abstract::Six strains of the cosmopolitan species D. immigrans from the Australian life zone plus one from the USA, show weak sexual isolation and more rarely sexual selection. Levels of sexual isolation cannot be related to geographic distances. Assortative mating may have evolved as a byproduct of ecological divergence. ...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01065601
更新日期:1980-07-01 00:00:00
abstract::Among three sibling species of the D. melanogaster subgroup, two are generalists (D. simulans and D. mauritiana), while the third, D. sechellia, specializes on a single toxic resource, the fruit of Morinda citrifolia. D. sechellia, resistant to the toxics, prefers to oviposit on morinda; D. simulans, which is very sen...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01076179
更新日期:1994-09-01 00:00:00
abstract::Voluntary physical activity may be related to personality traits. Here, we investigated these relations in two mouse lines selectively bred for high voluntary wheel-running behavior and in one non-selected control line. Selection lines were more explorative and "information gathering" in the open-field test, either wi...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-010-9359-8
更新日期:2010-07-01 00:00:00
abstract::Sixty-six mice of 11 genetic stocks (the Bailey recombinant inbred strains CXBD, CXBE, CXBG, CXBH, CXBI, CXBJ, CXBK; their progenitor strains, BALB/cBy and C57BL/6By: and the reciprocal hybrids, B6CF and CB6F) were tested in a two-compartment apparatus and in a shuttlebox, with five measures taken relating to activity...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01066277
更新日期:1977-05-01 00:00:00
abstract::If appropriately determined, recombinant-inbred (RI) strain means provide an excellent method for determining genetic correlations among complex characters. However, little systematic attention has been paid to important environmental influences on strain means such as random effects due to litter membership or system...
journal_title:Behavior genetics
pub_type: 杂志文章,评审
doi:10.1007/BF01066634
更新日期:1992-11-01 00:00:00
abstract::A complimentary two-phase strategy was used to detect and map quantitative trait loci (QTLs) associated with the basal locomotor response to a saline challenge (10 ml/kg). In phase 1, putative QTLs, significant at p < 0.01 or better, were identified by analysis of the strain means for 25 strains of the B x D recombina...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/a:1001963906258
更新日期:2000-05-01 00:00:00
abstract::Artificial selection was used to establish different levels of agonistic behavior in laboratory-reared wild female Mus musculus. A within-family selection design with replicated high and low lines and two nonselected control lines was employed. Females only were tested at 8 weeks of age on 2 consecutive days. Testing ...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01065725
更新日期:1976-07-01 00:00:00
abstract::Selection for geotaxis was carried out with flies from a natural population of Drosophila melanogaster; geotactic behavior was measured by means of a Hirsch classification maze. The population was initally almost neutral to gravity, and it responded to both positive (downward) and negative (upward) selection with a re...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01065679
更新日期:1976-01-01 00:00:00
abstract::A go/no-go operant task was used to assess the ability of male Long-Evans rats to discriminate between the urine odors from pairs of intact MHC congenic mice (C57BL/6-H-2Kb/J and C57BL/6-H-2Kbm1/ByJ), intact Y congenic mice (DBA1 and DBA1.C57BL10-Y), and castrated Y congenic mice of these two strains. The MHC congenic...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01082464
更新日期:1993-05-01 00:00:00