Abstract：
:Sixty-six mice of 11 genetic stocks (the Bailey recombinant inbred strains CXBD, CXBE, CXBG, CXBH, CXBI, CXBJ, CXBK; their progenitor strains, BALB/cBy and C57BL/6By: and the reciprocal hybrids, B6CF and CB6F) were tested in a two-compartment apparatus and in a shuttlebox, with five measures taken relating to activity and to approaches to novel and complex stimuli. A factor analysis of these measures revealed two factors, the first involving behavior relating to novel stimuli and the second relating to locomotor activity. In a second experiment, 132 mice of the same strains were tested on four of the measures used previously. On the two measures which had high loadings on the first factor and very low loadings on the second, it was possible to determine a strain distribution pattern (SDP), with the same SDP being found for both measures. When confirmed by testing mice from two congenic histocompatibility strains H(w54) and H(w80), we were able to determine that avoidance of novel/complex stimuli (neophobia) is controlled by a gene or genes at chromosomal segments H-24c and H-1b. It was also found that a polygenic model is consistent with behavior measured by the second (activity) factor.
journal_name
Behav Genetjournal_title
Behavior geneticsauthors
Simmel EC,Eleftheriou BEdoi
10.1007/BF01066277subject
Has Abstractpub_date
1977-05-01 00:00:00pages
239-50issue
3eissn
0001-8244issn
1573-3297journal_volume
7pub_type
杂志文章abstract：:Extreme sampling of sibling pairs has been shown to be efficient in terms of statistical power and sample sizes (in number of sibling pairs needed to genotype) to detect a quantitative trait locus (QTL) when the residual distribution is normal. In the present study, the efficiency of extreme sampling strategies to det...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/a:1014403827957
更新日期：2002-01-01 00:00:00
abstract：:In this study we examined cross-sectional age differences in means, phenotypic covariance structure, and the underlying genetic and environmental structure of four personality constructs from Cloninger's personality system: Novelty Seeking (NS), Harm Avoidance (HA), Reward Dependence (RD), and Persistence (PS). Study ...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/a:1022558002760
更新日期：2003-03-01 00:00:00
abstract：:To extend Purcell's well known ACE model in testing gene by measured environment interactions (GxM) in behavior genetic designs, Rathouz et al. considered a broader class of models for quantifying and testing such interactions. Only a sub-group of these extended models have been investigated for their statistical oper...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-015-9710-1
更新日期：2015-07-01 00:00:00
abstract：:A model of handedness incorporating both genetic and cultural processes is proposed, based on an evolutionary analysis, and maximum-likelihood estimates of its parameters are generated. This model has the characteristics that (i) no genetic variation underlies variation in handedness, and (ii) variation in handedness ...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF02253372
更新日期：1995-09-01 00:00:00
abstract：:Gonadotropin-releasing hormone (GnRH), having a highly conserved structure across mammalian species, plays a pivotal role in the control of the neuroendocrine events and the inherent sexual behaviors essential for reproductive function. Recent advances in molecular genetic technology have contributed greatly to the in...
journal_title：Behavior genetics
pub_type： 杂志文章,评审
doi：10.1007/BF02359383
更新日期：1996-05-01 00:00:00
abstract：:Current behavior genetic models can only employ limited types of phenotypic data, such as Likert scale data or continuous data, as variables. Here, a new method employing paired comparison data is presented within the framework of behavior genetic models. This model facilitates the estimation of genetic, shared enviro...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-007-9183-y
更新日期：2008-03-01 00:00:00
abstract：:Parameters of quantitative genetic models have traditionally been estimated by either algebraic manipulation of familial correlations (or familial mean squares), biometric model fitting, or multiple-group covariance structure analysis. With few exceptions, researchers who have used these methods for the analysis of tw...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01066662
更新日期：1992-05-01 00:00:00
abstract：:This article reports the results of 11 generations of selective breeding for isolation-induced, interfemale aggression in Mus musculus. Within-family selection was used to form two high, two low, and two unselected control lines, beginning with a population of wild-trapped mice. Selection was successful in establishin...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01065597
更新日期：1980-07-01 00:00:00
abstract：:In this article, we successfully apply the novel model selection method, Bayesian composite model space approach which has been used to map quantitative trait loci (QTL) for allelic substitution model, to map QTL for variance component model. The novel model selection approach has two advantages compared to the revers...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-009-9259-y
更新日期：2009-05-01 00:00:00
abstract：:A model based on the latent class model is developed for the effects of genes and environment on multivariate categorical data in twins. The model captures many essential features of dimensional and categorical conceptions of complex behavioral phenotypes and can include, as special cases, a variety of major locus mod...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01067550
更新日期：1993-01-01 00:00:00
abstract：:It is well established that many continuously distributed traits have a heritable component. However, it is often difficult to communicate to the general public the meaning of quantitative estimates of heritability. To address this problem, the present paper introduces a heuristic for communicating heritability to non...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/a:1025670316169
更新日期：1997-09-01 00:00:00
abstract：:Voluntary physical activity may be related to personality traits. Here, we investigated these relations in two mouse lines selectively bred for high voluntary wheel-running behavior and in one non-selected control line. Selection lines were more explorative and "information gathering" in the open-field test, either wi...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-010-9359-8
更新日期：2010-07-01 00:00:00
abstract：:Bullying comes in different forms, yet most previous genetically-sensitive studies have not distinguished between them. Given the serious consequences and the high prevalence of bullying, it is remarkable that the aetiology of bullying and its different forms has been under-researched. We present the first study to in...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-019-09968-5
更新日期：2019-09-01 00:00:00
abstract：:A study was conducted to identify quantitative trait loci (QTLs) that affect learning in honeybees. Two F1 supersister queens were produced from a cross between two established lines that had been selected for differences in the speed at which they reverse a learned discrimination between odors. Different families of ...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/a:1012227308783
更新日期：2001-05-01 00:00:00
abstract：:Courtship song serves as a sexual signal and may contribute to reproductive isolation between closely related species. Using lines of Drosophila pseudoobscura experimentally selected under different sexual selection regimes, we tested whether increased promiscuity and enforced monogamy led to evolutionary changes in c...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-005-3217-0
更新日期：2005-05-01 00:00:00
abstract：:In previous electrophysiological experiments from hypopigmented animals (mice, rats, rabbits), single-unit recordings from both retinal ganglion axons and cells in the superior colliculus have demonstrated an increase in threshold in the dark-adapted state which is roughly proportional to the ocular melanin concentrat...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01067442
更新日期：1993-07-01 00:00:00
abstract：:Here we provide a detailed description of the genome-wide information available on the National Longitudinal Study of Adolescent to Adult Health (Add Health) sibling pair subsample (Harris et al. in Twin Res Hum Genet 16:391-398, 2013). A total of 2,020 samples were genotyped (including duplicates) arising from 1946 A...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-014-9692-4
更新日期：2015-01-01 00:00:00
abstract：:Knowledge about the proportion of markers without effects (p( 0 )) and the effect sizes in large scale genetic studies is important to understand the basic properties of the data and for applications such as the control of false discoveries and designing adequately powered replication studies. Many p(0) estimators hav...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-009-9321-9
更新日期：2010-05-01 00:00:00
abstract：:In studies of child psychopathology, phenotypes of interest are often obtained by parental ratings. When behavioral ratings are obtained in the context of a twin study, this allows for the decomposition of the phenotypic variance, into a genetic and a non-genetic part. If a phenotype is assessed by a single rater, her...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-016-9823-1
更新日期：2017-03-01 00:00:00
abstract：:Reading difficulties are both heritable and stable; however, little is known about the etiology of this stability. Results from a preliminary analysis of data from 56 twin pairs who participated in the Colorado Longitudinal Twin Study of Reading Disability (Astrom et al., Twin Res Hum Genet 10:434-439, 2007) suggested...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-011-9445-6
更新日期：2011-09-01 00:00:00
abstract：:Among three sibling species of the D. melanogaster subgroup, two are generalists (D. simulans and D. mauritiana), while the third, D. sechellia, specializes on a single toxic resource, the fruit of Morinda citrifolia. D. sechellia, resistant to the toxics, prefers to oviposit on morinda; D. simulans, which is very sen...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01076179
更新日期：1994-09-01 00:00:00
abstract：:There is considerable evidence that sex differences in spatial ability exist in adults, with males outperforming females at every age after puberty. It is difficult, however, to find sex differences in children younger than 13. This is due in part to the lack of adequate measures of spatial ability for use with childr...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01065974
更新日期：1991-07-01 00:00:00
abstract：:The conditioned and reflex parameters in rat lines selected for the threshold of excitability (a fundamental characteristics of the functional state of the nervous system) were estimated. This measure is based on the response of the tibial nerve to electrical stimulation, which gives a general indication of the level ...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01067986
更新日期：1993-09-01 00:00:00
abstract：:The goal of the present study is to examine genetic and environmental influences on maternal and teacher ratings of Attention Problems (AP) in 7-year-old children. Teachers completed the Teacher Report Form (N=2259 pairs), and mothers the Child Behavior Checklist (N=2057 pairs). Higher correlations were found in twins...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-006-9084-5
更新日期：2006-11-01 00:00:00
abstract：:The attempt to characterize high- and low-selected lines on new variables poses serious interpretative problems when replicate lines are not available. Modest but significant line differences on new measures may be due to genetic drift totally irrelevant to the originally selected trait. Often these differences are ex...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01066250
更新日期：1989-07-01 00:00:00
abstract：:Roman high- and low-avoidance (RHA/Verh and RLA/Verh) rats are selected and bred for extreme divergence in two-way active avoidance acquisition. In addition, compared to RLA/Verh rats, RHA/Verh rats are (behaviorally and physiologically) less anxious or reactive to stressors, show increased novelty (sensation)-seeking...
journal_title：Behavior genetics
pub_type： 杂志文章,评审
doi：10.1023/a:1021400830503
更新日期：1997-11-01 00:00:00
abstract：:Recent studies have identified genes that influence the length of the circadian period maintained by mice housed under constant lighting conditions. However, a less studied circadian activity variable is the amplitude of daily oscillations in locomotor activity. This parameter reflects spontaneous activity exhibited u...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/a:1021657800287
更新日期：1999-09-01 00:00:00
abstract：:Two ongoing selective breeding projects have produced mice that display divergent analgesic responses to morphine. These two projects have selected for similar phenotypes: high and low levorphanol analgesia (HAR/LAR lines; Portland, OR) and high and low swim stress-induced analgesia (HA/LA lines; Jastrzebiec, Poland)....
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF02197290
更新日期：1995-07-01 00:00:00
abstract：:We present a repeated-measures, genetic analysis of ethanol-induced anesthesia (sleep time) in mice from the inbred long-sleep (ILS) and short-sleep (ISS) strains of mice and their derived F1 and F2 generations. Mice (total N > 1300) were administered a 4.1 g/kg intraperitoneal dose of ethanol at two times, 7 to 10 da...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF02197243
更新日期：1995-01-01 00:00:00
abstract：:We examined longitudinally collected behavioral reports by teachers on a unique twin sample at the ages of 7, 8, 9, 10, 11, and 12 years. As twin and adoption studies implicate the role of genetic influence on behavioral problems found to be stable in epidemiological samples, the current study employs a developmental ...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-004-1747-5
更新日期：2005-07-01 00:00:00
