Short-Term Genetic Selection for Adolescent Locomotor Sensitivity to Delta9-Tetrahydrocannabinol (THC).

Abstract:

:Cannabis use is linked to positive and negative outcomes. Identifying genetic targets of susceptibility to the negative effects of cannabinoid use is of growing importance. The current study sought to complete short-term selective breeding for adolescent sensitivity and resistance to the locomotor effects of a single 10 mg/kg THC dose in the open field. Selection for THC-locomotor sensitivity was moderately heritable, with the greatest estimates of heritability seen in females from the F2 to S3 generations. Selection for locomotor sensitivity also resulted in increased anxiety-like activity in the open field. These results are the first to indicate that adolescent THC-locomotor sensitivity can be influenced via selective breeding. Development of lines with a genetic predisposition for THC-sensitivity or resistance to locomotor effects allow for investigation of risk factors, differences in consequences of THC use, identification of correlated behavioral responses, and detection of genetic targets that may contribute to heightened cannabinoid sensitivity.

journal_name

Behav Genet

journal_title

Behavior genetics

authors

Kasten CR,Zhang Y,Mackie K,Boehm SL 2nd

doi

10.1007/s10519-018-9894-2

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

224-235

issue

3

eissn

0001-8244

issn

1573-3297

pii

10.1007/s10519-018-9894-2

journal_volume

48

pub_type

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