Abstract:
:Cannabis use is linked to positive and negative outcomes. Identifying genetic targets of susceptibility to the negative effects of cannabinoid use is of growing importance. The current study sought to complete short-term selective breeding for adolescent sensitivity and resistance to the locomotor effects of a single 10 mg/kg THC dose in the open field. Selection for THC-locomotor sensitivity was moderately heritable, with the greatest estimates of heritability seen in females from the F2 to S3 generations. Selection for locomotor sensitivity also resulted in increased anxiety-like activity in the open field. These results are the first to indicate that adolescent THC-locomotor sensitivity can be influenced via selective breeding. Development of lines with a genetic predisposition for THC-sensitivity or resistance to locomotor effects allow for investigation of risk factors, differences in consequences of THC use, identification of correlated behavioral responses, and detection of genetic targets that may contribute to heightened cannabinoid sensitivity.
journal_name
Behav Genetjournal_title
Behavior geneticsauthors
Kasten CR,Zhang Y,Mackie K,Boehm SL 2nddoi
10.1007/s10519-018-9894-2subject
Has Abstractpub_date
2018-05-01 00:00:00pages
224-235issue
3eissn
0001-8244issn
1573-3297pii
10.1007/s10519-018-9894-2journal_volume
48pub_type
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