Abstract：
:A complimentary two-phase strategy was used to detect and map quantitative trait loci (QTLs) associated with the basal locomotor response to a saline challenge (10 ml/kg). In phase 1, putative QTLs, significant at p < 0.01 or better, were identified by analysis of the strain means for 25 strains of the B x D recombinant inbred series. QTLs were identified on chromosomes 1, 3, 5, 9, 10, 16, and 18. Some of these QTLs were detected across the entire experimental period (0-20 min), while others were associated with specific 5-min blocks. Eighteen hundred C57BL/6J (B6) x DBA/2J (D2) F2 intercross animals were phenotyped for the basal locomotor response, and of this group, 500 to 700 individuals, pseudo-randomly selected, were used for a genomewide scan to confirm the RI-generated QTLs and to detect new QTLs. No new QTLs were detected but the QTLs on chromosome 1 were confirmed at p < 10(-5) to p < 10(-9), depending on the time interval. In addition, the QTLs on chromosomes 5 and 9 were confirmed at p < 0.001, providing a combined probability (RI + F2) which exceeds the threshold for a significant association. Two additional phenotypes which showed significant RI strain differences were examined--adaptation and thigmotaxis. Adaptation mapped to the same region of chromosome 9 and thigmotaxis to the same region of chromosome 1 as the distance-traveled QTL. Overall, the data presented here and elsewhere (Flint et al., 1995; Gershenfeld et al., 1997) illustrate that QTLs for basal activity are both robust and reliable.
journal_name
Behav Genetjournal_title
Behavior geneticsauthors
Koyner J,Demarest K,McCaughran J Jr,Cipp L,Hitzemann Rdoi
10.1023/a:1001963906258subject
Has Abstractpub_date
2000-05-01 00:00:00pages
159-70issue
3eissn
0001-8244issn
1573-3297journal_volume
30pub_type
杂志文章abstract：:The multiple regression methodology proposed by DeFries and Fulker (DF; 1985, 1988) for the analysis of twin data is compared with maximum-likelihood estimation of genetic and environmental parameters from covariance structure. Expectations for the regression coefficients from submodels omitting the h2 and c2 terms ar...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01066617
更新日期：1992-07-01 00:00:00
abstract：:Roman high- and low-avoidance (RHA/Verh and RLA/Verh) rats are selected and bred for extreme divergence in two-way active avoidance acquisition. In addition, compared to RLA/Verh rats, RHA/Verh rats are (behaviorally and physiologically) less anxious or reactive to stressors, show increased novelty (sensation)-seeking...
journal_title：Behavior genetics
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doi：10.1023/a:1021400830503
更新日期：1997-11-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/a:1021657800287
更新日期：1999-09-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-010-9402-9
更新日期：2011-01-01 00:00:00
abstract：:Chronic pelvic pain (CPP) is a common condition in women that is difficult to diagnose. Although heritability estimates have been published for some conditions potentially underlying pelvic pain, the heritability of CPP itself has never been investigated. Using data from 623 MZ and 377 DZ female twin pairs aged 29-50 ...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-004-1017-6
更新日期：2005-03-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01066250
更新日期：1989-07-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-013-9632-8
更新日期：2014-01-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-014-9691-5
更新日期：2015-05-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-006-9132-1
更新日期：2007-03-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/a:1015253807488
更新日期：2002-03-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01073209
更新日期：1975-10-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01065462
更新日期：1981-05-01 00:00:00
abstract：:A genetic analysis of differences in reactivity to early exposure of female BALB/cBy and C57BL/6By mice to testosterone was performed using the C x B recombinant-inbred (RI) strains. RI female mice were given a single injection of 1 mg of testosterone propionate on day 4 of life and observed in adulthood in the presen...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01070741
更新日期：1990-01-01 00:00:00
abstract：:We present a repeated-measures, genetic analysis of ethanol-induced anesthesia (sleep time) in mice from the inbred long-sleep (ILS) and short-sleep (ISS) strains of mice and their derived F1 and F2 generations. Mice (total N > 1300) were administered a 4.1 g/kg intraperitoneal dose of ethanol at two times, 7 to 10 da...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF02197243
更新日期：1995-01-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章,评审
doi：10.1007/BF02359383
更新日期：1996-05-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/a:1025601828464
更新日期：1997-05-01 00:00:00
abstract：:Voluntary physical activity may be related to personality traits. Here, we investigated these relations in two mouse lines selectively bred for high voluntary wheel-running behavior and in one non-selected control line. Selection lines were more explorative and "information gathering" in the open-field test, either wi...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-010-9359-8
更新日期：2010-07-01 00:00:00
abstract：:It is well established that many continuously distributed traits have a heritable component. However, it is often difficult to communicate to the general public the meaning of quantitative estimates of heritability. To address this problem, the present paper introduces a heuristic for communicating heritability to non...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/a:1025670316169
更新日期：1997-09-01 00:00:00
abstract：:Individuals involved in a social interaction exhibit different behavioral traits that, in combination, form the individual's behavioral responses. Selectively bred strains of silver foxes (Vulpes vulpes) demonstrate markedly different behaviors in their response to humans. To identify the genetic basis of these behavi...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-016-9815-1
更新日期：2017-01-01 00:00:00
abstract：:A model based on the latent class model is developed for the effects of genes and environment on multivariate categorical data in twins. The model captures many essential features of dimensional and categorical conceptions of complex behavioral phenotypes and can include, as special cases, a variety of major locus mod...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01067550
更新日期：1993-01-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/a:1025633307992
更新日期：1997-03-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/a:1023450625826
更新日期：2003-05-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01066331
更新日期：1991-03-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01065728
更新日期：1976-07-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01065888
更新日期：1989-01-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/a:1013357714500
更新日期：2001-11-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-005-6119-2
更新日期：2005-11-01 00:00:00
abstract：:Genetic strains of mice represent an important resource for research on the biological determinants of complex diseases and behavioral phenotypes. To date, the approaches used have had little success in identifying causal genes. We have evaluated brain gene expression in C57BL/6J (B6) and DBA/2J (D2) inbred mouse stra...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/B:BEGE.0000023648.78190.ee
更新日期：2004-07-01 00:00:00
abstract：:Heritability estimates of birth weight have been inconsistent. Possible explanations are heritability changes during gestational age or the influence of covariates (e.g. chorionicity). The aim of this study was to model birth weights of twins across gestational age and to quantify the genetic and environmental compone...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-007-9170-3
更新日期：2008-01-01 00:00:00
abstract：:As a result of different feeding regimens, two laboratory populations of the beetle Callosobruchus maculatus Fab. developed different rates of oviposition. The behavior of the F1 hybrids cannot be explained with an additive model of inheritance. The unusual pattern of inheritance suggests a sex-related factor(s) and a...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01065625
更新日期：1981-03-01 00:00:00
