Abstract：
:We present a repeated-measures, genetic analysis of ethanol-induced anesthesia (sleep time) in mice from the inbred long-sleep (ILS) and short-sleep (ISS) strains of mice and their derived F1 and F2 generations. Mice (total N > 1300) were administered a 4.1 g/kg intraperitoneal dose of ethanol at two times, 7 to 10 days apart. A method suggested by Cohen was used to analyze the resulting data, which contained a known number of unmeasured observations. A genetic model that included both additive and epistatic parameters fitted the adjusted data well. A novel procedure for estimating heritability, based on a comparison of repeatability coefficients from the isogenic and genetically segregating populations, was also employed. Results of this analysis suggested that the heritability for individual measurements of sleep time is about .30, whereas the heritability of average scores is about .40. Results of this analysis also confirm that the ILS and ISS strains differ for genes at seven or more loci that influence sleep time. Since the ILS and ISS were derived by inbreeding the LS and SS lines, these results further suggest that almost all of the genetic variation present in the selected lines have been maintained in the ILS and ISS strains.
journal_name
Behav Genetjournal_title
Behavior geneticsauthors
Markel PD,DeFries JC,Johnson TEdoi
10.1007/BF02197243subject
Has Abstractpub_date
1995-01-01 00:00:00pages
67-73issue
1eissn
0001-8244issn
1573-3297journal_volume
25pub_type
杂志文章abstract：:Roman high- and low-avoidance (RHA/Verh and RLA/Verh) rats are selected and bred for extreme divergence in two-way active avoidance acquisition. In addition, compared to RLA/Verh rats, RHA/Verh rats are (behaviorally and physiologically) less anxious or reactive to stressors, show increased novelty (sensation)-seeking...
journal_title：Behavior genetics
pub_type： 杂志文章,评审
doi：10.1023/a:1021400830503
更新日期：1997-11-01 00:00:00
abstract：:In epidemiological and twin populations, prior interview studies have identified an externalizing spectrum of disorders. Could this be detected utilizing objective registry data? In 20,603 twin pairs from the Swedish Twin Registry, we obtained information from national medical, criminal and pharmacy records on drug ab...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-015-9741-7
更新日期：2016-03-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-019-09988-1
更新日期：2020-03-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01068210
更新日期：1979-07-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-017-9840-8
更新日期：2017-05-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01065679
更新日期：1976-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s10519-014-9664-8
更新日期：2014-09-01 00:00:00
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journal_title：Behavior genetics
pub_type： 传,历史文章,杂志文章
doi：10.1007/BF01066805
更新日期：1975-04-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01065901
更新日期：1989-03-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-009-9308-6
更新日期：2010-01-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-019-09971-w
更新日期：2020-01-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01067713
更新日期：1990-07-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/a:1002090627601
更新日期：2000-01-01 00:00:00
abstract：:The most common alternative to a genetic explanation of left-handedness is that sinistrality arises because of birth stress factors. In a sample of 1398 subjects, the association between birth stress and left-handedness was confirmed. More importantly, it was found that left-handed mothers are more likely to have birt...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF02327575
更新日期：1995-11-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01066177
更新日期：1975-07-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-014-9676-4
更新日期：2015-01-01 00:00:00
abstract：:Biometric studies have shown that happiness is strongly affected by genes. The findings are mainly based on twin data, however, and the full validity of the results has been debated. To overcome some limitations in classical twin research, we examined aetiological sources of subjective well-being (SWB), using two inde...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-010-9365-x
更新日期：2010-09-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF02197280
更新日期：1995-07-01 00:00:00
abstract：:Artificial selection was used to establish different levels of agonistic behavior in laboratory-reared wild female Mus musculus. A within-family selection design with replicated high and low lines and two nonselected control lines was employed. Females only were tested at 8 weeks of age on 2 consecutive days. Testing ...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01065725
更新日期：1976-07-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/a:1021631122461
更新日期：1999-11-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01065462
更新日期：1981-05-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01073648
更新日期：1980-09-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-006-9132-1
更新日期：2007-03-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01065888
更新日期：1989-01-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-020-10005-z
更新日期：2020-09-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/a:1014403827957
更新日期：2002-01-01 00:00:00
abstract：:Testis specific protein, Y-encoded-like 2 (TSPYL2) regulates the expression of genes encoding glutamate receptors. Glutamate pathology is implicated in neurodevelopmental conditions such as autism spectrum disorder, attention deficit hyperactivity disorder (ADHD) and schizophrenia. In line with this, a microduplicatio...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-015-9777-8
更新日期：2016-07-01 00:00:00
abstract：:Cannabis use is linked to positive and negative outcomes. Identifying genetic targets of susceptibility to the negative effects of cannabinoid use is of growing importance. The current study sought to complete short-term selective breeding for adolescent sensitivity and resistance to the locomotor effects of a single ...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-018-9894-2
更新日期：2018-05-01 00:00:00
abstract：:Based on the reviewed literature and the data presented in this paper, conclusions can be drawn with respect to the validity of the WAG/Rij strain of rats as a model for absence epilepsy in humans. The view that the WAG/Rij model has "face validity" is supported by the simultaneous presence of clinical and electroence...
journal_title：Behavior genetics
pub_type： 杂志文章,评审
doi：10.1023/a:1026179013847
更新日期：2003-11-01 00:00:00
abstract：:We used an alternate age variable, functional biological age (fBioAge), which was based on performance on functional body measures. The aim was to examine development of fBioAge across the adult life span, and to also examine potential gender differences and genetic and environmental influences on change with age. We ...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-017-9851-5
更新日期：2017-07-01 00:00:00
