Abstract:
:Roman high- and low-avoidance (RHA/Verh and RLA/Verh) rats are selected and bred for extreme divergence in two-way active avoidance acquisition. In addition, compared to RLA/Verh rats, RHA/Verh rats are (behaviorally and physiologically) less anxious or reactive to stressors, show increased novelty (sensation)-seeking behavior as well as a higher preference for rewarding substances, and are usually less efficient in learning tasks not involving shock administration. The present article reviews evidence showing that neonatal handling and/or environmental enrichment leads to enduring effects (their magnitude frequently depending upon the rat line) on those behaviors. For example, it has been found that neonatal handling reduces most of the (behavioral and physiological) signs of emotionality/anxiety in RLA/Verh rats, while environmental enrichment increases their novelty seeking (also the case with RHA/Verh rats), saccharin and ethanol intake, and sensitivity to amphetamine. Finally, initial results (currently being further elaborated upon) support a preventive action of both environmental treatments on age-related impairments in learning a spatial, water maze task as well as on hippocampal neuronal atrophy.
journal_name
Behav Genetjournal_title
Behavior geneticsauthors
Fernández-Teruel A,Escorihuela RM,Castellano B,González B,Tobeña Adoi
10.1023/a:1021400830503subject
Has Abstractpub_date
1997-11-01 00:00:00pages
513-26issue
6eissn
0001-8244issn
1573-3297journal_volume
27pub_type
杂志文章,评审abstract::Genetic strains of mice represent an important resource for research on the biological determinants of complex diseases and behavioral phenotypes. To date, the approaches used have had little success in identifying causal genes. We have evaluated brain gene expression in C57BL/6J (B6) and DBA/2J (D2) inbred mouse stra...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/B:BEGE.0000023648.78190.ee
更新日期:2004-07-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01076179
更新日期:1994-09-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-010-9380-y
更新日期:2011-03-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01065728
更新日期:1976-07-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01068210
更新日期:1979-07-01 00:00:00
abstract::Structural equation modeling (SEM) provides a flexible tool to carry out genetic analyses of family and twin data. The basic model which decomposes the variance between and within families for a particular trait into genetic and non-genetic components can be generalized to multivariate and/or longitudinal data, incorp...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-005-2791-5
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journal_title:Behavior genetics
pub_type: 评论,杂志文章
doi:10.1007/BF01067000
更新日期:1992-03-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章,评审
doi:10.1007/s10519-011-9444-7
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-006-9132-1
更新日期:2007-03-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
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abstract::Gender-moderated gene-environment interactions are rarely explored, raising concerns about inaccurate specification of etiological models and inferential errors. The current study examined the influence of gender, negative and positive daily life events, and GABRA2 genotype (SNP rs279871) on alcohol dependence, testin...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-013-9607-9
更新日期:2013-09-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01065601
更新日期:1980-07-01 00:00:00
abstract::Knowledge about the proportion of markers without effects (p( 0 )) and the effect sizes in large scale genetic studies is important to understand the basic properties of the data and for applications such as the control of false discoveries and designing adequately powered replication studies. Many p(0) estimators hav...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-009-9321-9
更新日期:2010-05-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-008-9197-0
更新日期:2008-05-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01067986
更新日期:1993-09-01 00:00:00
abstract::We developed a zygosity questionnaire for use in young twins and assessed its validity using the results of DNA diagnosis. The participants were divided into two groups: 105 pairs of adolescent twins (12-16 years old), 47 pairs of child twins (2-12 years old), and their respective parents. The DNA diagnosis of zygosit...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/a:1021660506222
更新日期:1999-03-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-007-9150-7
更新日期:2007-07-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/a:1012227308783
更新日期:2001-05-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF02359484
更新日期:1996-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s10519-014-9691-5
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pub_type: 杂志文章
doi:10.1007/BF01065625
更新日期:1981-03-01 00:00:00
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pub_type: 已发布勘误
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01066331
更新日期:1991-03-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/a:1022558002760
更新日期:2003-03-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
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更新日期:1999-09-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01067431
更新日期:1993-07-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01067187
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01065679
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