Abstract：
:Substantial progress has been made recently in analyses of longitudinal twin and family data, principally for two reasons. The first is the continuing development of more refined models for describing longitudinal data; the second is the widespread availability of analytic methods (e.g. LISREL) with which to implement these models. Computational restrictions have limited likelihood-based analyses of longitudinal genetic data to analyses of covariance matrices or mean squares; however, advances in computer technology now make it feasible to conduct likelihood analyses of longitudinal pedigree data. We consider potential advantages of using pedigree-based methods. Our initial experiences with the application of these methods to simulated twin data, using the FISHER (Lange, K.L., et al., Genet. Epidemiol. 5:471, 1988) quantitative genetics package, are discussed, with particular attention to practical details such as running times on several computers. Preliminary results of the pedigree-based analyses, including robust estimation methods, convincingly demonstrate the failure of methods assuming the multivariate normal distribution for simulated twin data provided by Carey (this issue).
journal_name
Behav Genetjournal_title
Behavior geneticsauthors
Williams CJ,Viken R,Rose RJdoi
10.1007/BF01067000subject
Has Abstractpub_date
1992-03-01 00:00:00pages
215-23issue
2eissn
0001-8244issn
1573-3297journal_volume
22pub_type
评论,杂志文章abstract：:Individuals involved in a social interaction exhibit different behavioral traits that, in combination, form the individual's behavioral responses. Selectively bred strains of silver foxes (Vulpes vulpes) demonstrate markedly different behaviors in their response to humans. To identify the genetic basis of these behavi...
journal_title：Behavior genetics
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doi：10.1007/s10519-016-9815-1
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abstract：:Parameters of quantitative genetic models have traditionally been estimated by either algebraic manipulation of familial correlations (or familial mean squares), biometric model fitting, or multiple-group covariance structure analysis. With few exceptions, researchers who have used these methods for the analysis of tw...
journal_title：Behavior genetics
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abstract：:In epidemiological and twin populations, prior interview studies have identified an externalizing spectrum of disorders. Could this be detected utilizing objective registry data? In 20,603 twin pairs from the Swedish Twin Registry, we obtained information from national medical, criminal and pharmacy records on drug ab...
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journal_title：Behavior genetics
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更新日期：2006-01-01 00:00:00
abstract：:Twin studies are useful for assessing the relative importance of genetic or heritable component from the environmental component. In this paper we develop a methodology to study the heritability of age-at-onset or lifespan traits, with application to analysis of twin survival data. Due to limited period of observation...
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更新日期：2007-07-01 00:00:00
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journal_title：Behavior genetics
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doi：10.1007/BF02361157
更新日期：1996-01-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/B:BEGE.0000017875.78571.a6
更新日期：2004-05-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01070002
更新日期：1981-09-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-012-9537-y
更新日期：2012-07-01 00:00:00
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journal_title：Behavior genetics
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更新日期：1996-05-01 00:00:00
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journal_title：Behavior genetics
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01066177
更新日期：1975-07-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01067187
更新日期：1994-05-01 00:00:00
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更新日期：2014-07-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-015-9734-6
更新日期：2016-01-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/a:1021494023660
更新日期：1999-01-01 00:00:00
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journal_title：Behavior genetics
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doi：10.1007/s10519-010-9332-6
更新日期：2010-03-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/a:1002090627601
更新日期：2000-01-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/a:1021671313974
更新日期：1998-07-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章,评审
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更新日期：1997-07-01 00:00:00
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更新日期：2014-01-01 00:00:00
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journal_title：Behavior genetics
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更新日期：2005-07-01 00:00:00
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journal_title：Behavior genetics
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doi：10.1023/a:1025601828464
更新日期：1997-05-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-015-9710-1
更新日期：2015-07-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF02359756
更新日期：1996-09-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01066164
更新日期：1989-05-01 00:00:00
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journal_title：Behavior genetics
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更新日期：1994-03-01 00:00:00
