Abstract:
:Latent variable models are used in biological and social sciences to investigate characteristics that are not directly measurable. The generation of individual scores of latent variables can simplify subsequent analyses. However, missing measurements in real data complicate the calculation of scores. Missing observations also result in different latent variable scores having different degrees of accuracy which should be taken into account in subsequent analyses. This manuscript presents a publicly available software tool that addresses both these problems, using as an example a dataset consisting of multiple ratings for ADHD symptomatology in children. The program computes latent variable scores with accompanying accuracy indices, under a 'user-specified' structural equation model, in data with missing data patterns. Since structural equation models encompass factor models, it can also be used for calculating factor scores. The program, documentation and a tutorial, containing worked examples and specimen input and output files, is available at http://statgen.iop.kcl.ac.uk/lsc .
journal_name
Behav Genetjournal_title
Behavior geneticsauthors
Campbell DD,Rijsdijk FV,Sham PCdoi
10.1007/s10519-006-9123-2subject
Has Abstractpub_date
2007-03-01 00:00:00pages
408-22issue
2eissn
0001-8244issn
1573-3297journal_volume
37pub_type
杂志文章abstract::This study documented the etiology contributions between anxiety symptoms (AS) and depressive symptoms (DS) from ages 6-12 years. Teachers assessed AS and DS in 1112 twins at 5 time points. A genetic cross-lagged model was used to estimate genetic/environmental contributions to cross-sectional, cross-age and cross-lag...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-019-09988-1
更新日期:2020-03-01 00:00:00
abstract::Parameters of quantitative genetic models have traditionally been estimated by either algebraic manipulation of familial correlations (or familial mean squares), biometric model fitting, or multiple-group covariance structure analysis. With few exceptions, researchers who have used these methods for the analysis of tw...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01066662
更新日期:1992-05-01 00:00:00
abstract::We analyzed the genetic architecture of prepubertal development of relative weight to height in 216 monozygotic and 159 dizygotic complete Japanese twin pairs (52% girls). Ponderal index at birth (kg/m(3)) and body mass index (BMI, kg/m(2)) from 1 to 11 years of age were used. Additive genetic factors explained the ma...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-010-9380-y
更新日期:2011-03-01 00:00:00
abstract::Components of the communication system between infant and adult rodents based on ultrasonic vocalizations (USVs) of infants are analyzed. USVs are most often emitted from a pup lost outside the nest in response to changes of: (i) body temperature, (ii) contact with adults/littermates, (iii) handling, and (iv) smell. T...
journal_title:Behavior genetics
pub_type: 杂志文章,评审
doi:10.1007/s10519-004-0853-8
更新日期:2005-01-01 00:00:00
abstract::In this study we examined cross-sectional age differences in means, phenotypic covariance structure, and the underlying genetic and environmental structure of four personality constructs from Cloninger's personality system: Novelty Seeking (NS), Harm Avoidance (HA), Reward Dependence (RD), and Persistence (PS). Study ...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/a:1022558002760
更新日期:2003-03-01 00:00:00
abstract::Genomewide scan, as shown by recently published linkage studies on the behavior of mice or in psychiatry, provides evidence for replicated quantitative trait loci (QTL). Several studies of Alzheimer's disease have demonstrated the promise of moving from clinical diagnoses to biological signs for psychiatric investigat...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/a:1010222328509
更新日期:2001-01-01 00:00:00
abstract::The role of non-shared environment (NSE) in the development of psychological traits is usually comparable with that of the genotype. However, no specific factors of NSE with significant impact on such traits have been discovered so far. We propose that the current failures in understanding the origin of NSE are at lea...
journal_title:Behavior genetics
pub_type: 杂志文章,评审
doi:10.1007/s10519-019-09950-1
更新日期:2019-05-01 00:00:00
abstract::Current behavior genetic models can only employ limited types of phenotypic data, such as Likert scale data or continuous data, as variables. Here, a new method employing paired comparison data is presented within the framework of behavior genetic models. This model facilitates the estimation of genetic, shared enviro...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-007-9183-y
更新日期:2008-03-01 00:00:00
abstract::In the course of the East Flanders Prospective Twin Survey (EFPTS), handedness was assessed as part of a genealogical study (Meulemans et al., 1995) in 1616 twins (808 twin pairs) aged 6 to 28. Our findings are that, in this large population-based study with known placentation and zygosity, the often observed higher f...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF02359484
更新日期:1996-07-01 00:00:00
abstract::The transmission of social attitudes has been investigated as a possible model of cultural inheritance in a sample of 3810 twin pairs from the Australian National Health and Medical Research Twin Registry. Six social attitude factors were identified and univariate genetic models fitted to scores on each factor. A join...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01066792
更新日期:1992-01-01 00:00:00
abstract::The heritability of human personality is well-established. Recent research indicates that nonadditive genetic effects, such as dominance and epistasis, play a large role in personality variation. One possible explanation for the latter finding is that there has been recent selection on human personality. To test this ...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-012-9537-y
更新日期:2012-07-01 00:00:00
abstract::Lurcher mutant mice were impaired in spatial orientation and motor coordination in comparison to normal mice. Both groups improved across days in both invisible and visible water maze platform conditions. Contrary to normal mice, lurcher mutants did not improve over days in terms of the time taken to reach a side-bar ...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01071563
更新日期:1994-11-01 00:00:00
abstract::Mutations on the period locus of Drosophila melanogaster influence circadian periods as well as the rhythm in inter-pulse intervals in male courtship song; perL mutations produce long circadian periods and courtship song rhythms and per(s) mutations produce short circadian periods and courtship song rhythms. Thus, the...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/a:1021625819967
更新日期:1998-09-01 00:00:00
abstract::Complex illnesses, like depression, are thought to arise from the interplay between psychosocial stressors and genetic predispositions. Approaches that take into account both personal and neighborhood factors and that consider gene regions as well as individual SNPs may be necessary to capture these interactions acros...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-015-9734-6
更新日期:2016-01-01 00:00:00
abstract::The non-synonymous SNP rs2228145 in the IL6R gene on chromosome 1q21.3 is associated with a wide range of common diseases, including asthma, rheumatoid arthritis, type 1 diabetes and coronary heart disease. We examined the contribution of this functional IL6R gene polymorphism rs2228145 versus other genome-wide SNPs t...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-014-9656-8
更新日期:2014-07-01 00:00:00
abstract::In previous electrophysiological experiments from hypopigmented animals (mice, rats, rabbits), single-unit recordings from both retinal ganglion axons and cells in the superior colliculus have demonstrated an increase in threshold in the dark-adapted state which is roughly proportional to the ocular melanin concentrat...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01067442
更新日期:1993-07-01 00:00:00
abstract::Anxiety disorders are phenotypically complex and may involve multiple genetic influences on many neurotransmitter systems. Rodent tests used to investigate genetic influences on anxiety-like phenotypes have face and predictive validity as models for anxiety in humans. If multiple genes contribute additively to a trait...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/B:BEGE.0000009479.02183.1f
更新日期:2004-01-01 00:00:00
abstract::Inhibitory control (IC) is a dimension of child temperament that emerges in toddlerhood and involves the ability to regulate behavior in response to instructions or expectations. In general, children with low levels of IC have more cognitive and social difficulties, and higher levels of problem behaviors. Unfortunatel...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-009-9316-6
更新日期:2010-05-01 00:00:00
abstract::This paper uses data from the National Longitudinal Study of Adolescent Health to examine the extent to which school-level social and institutional factors moderate genetic tendencies to smoke cigarettes. Our analysis relies on a sub-sample of 1,198 sibling and twin pairs nested within 84 schools. We develop a multile...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-008-9197-0
更新日期:2008-05-01 00:00:00
abstract::We investigated the extent to which performance on standardized achievement tests, executive function (EF), and aggression in childhood and adolescence accounted for the relationship between a polygenic score for educational attainment (EA PGS) and years of education in a community sample of African Americans. Partici...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-019-09982-7
更新日期:2020-01-01 00:00:00
abstract::The ability to learn and remember is variable within a population of a given species, including humans. This is due in part to genetic variation between individuals. However, only few genes have been identified that contribute to variation in learning and memory. Two inbred mouse strains, C57Bl/6J (B6) and DBA/2J (D2)...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-010-9387-4
更新日期:2011-03-01 00:00:00
abstract::A genetic analysis of differences in reactivity to early exposure of female BALB/cBy and C57BL/6By mice to testosterone was performed using the C x B recombinant-inbred (RI) strains. RI female mice were given a single injection of 1 mg of testosterone propionate on day 4 of life and observed in adulthood in the presen...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01070741
更新日期:1990-01-01 00:00:00
abstract::The goal of the present study is to examine genetic and environmental influences on maternal and teacher ratings of Attention Problems (AP) in 7-year-old children. Teachers completed the Teacher Report Form (N=2259 pairs), and mothers the Child Behavior Checklist (N=2057 pairs). Higher correlations were found in twins...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-006-9084-5
更新日期:2006-11-01 00:00:00
abstract::The most common alternative to a genetic explanation of left-handedness is that sinistrality arises because of birth stress factors. In a sample of 1398 subjects, the association between birth stress and left-handedness was confirmed. More importantly, it was found that left-handed mothers are more likely to have birt...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF02327575
更新日期:1995-11-01 00:00:00
abstract::Sex differences in genetic and environmental influences on criminal behavior against property were studied in a birth cohort of 6129 male and 7065 female Danish adoptees and their biological and adoptive parents. Both genetic and environmental factors were found to contribute to variation in liability to property crim...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01066164
更新日期:1989-05-01 00:00:00
abstract::Extreme sampling of sibling pairs has been shown to be efficient in terms of statistical power and sample sizes (in number of sibling pairs needed to genotype) to detect a quantitative trait locus (QTL) when the residual distribution is normal. In the present study, the efficiency of extreme sampling strategies to det...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/a:1014403827957
更新日期:2002-01-01 00:00:00
abstract::: We report heritabilities for individual differences in female pubertal development at the age of 12. Tanner data on breast and pubic hair development in girls and data on menarche were obtained from a total of 184 pairs of monozygotic and dizygotic twins. Genetic correlations were estimated to determine to what exte...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-005-9022-y
更新日期:2006-03-01 00:00:00
abstract::In a study designed to investigate genotype-environment interaction, eight strains of laboratory rats were crossbred in a replicated diallel cross employing infantile stimulation and its absence as environmental treatments. This paper reports on measures of the acquisition of two-way escape-avoidance conditioning, com...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01070816
更新日期:1981-07-01 00:00:00
abstract::The Inositol 1,4,5-triphosphate (IP3) route is one of the two main transduction cascades that mediate olfactory reception in Drosophila melanogaster. The activity of IP3 kinase1 reduces the levels of this substrate by phosphorylation into inositol 1,3,4,5-tetrakiphosphate (IP4). We show here that the gene is expressed...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-005-9031-x
更新日期:2006-03-01 00:00:00
abstract::If appropriately determined, recombinant-inbred (RI) strain means provide an excellent method for determining genetic correlations among complex characters. However, little systematic attention has been paid to important environmental influences on strain means such as random effects due to litter membership or system...
journal_title:Behavior genetics
pub_type: 杂志文章,评审
doi:10.1007/BF01066634
更新日期:1992-11-01 00:00:00