Genetic regulation of pre-pubertal development of body mass index: a longitudinal study of Japanese twin boys and girls.

Abstract:

:We analyzed the genetic architecture of prepubertal development of relative weight to height in 216 monozygotic and 159 dizygotic complete Japanese twin pairs (52% girls). Ponderal index at birth (kg/m(3)) and body mass index (BMI, kg/m(2)) from 1 to 11 years of age were used. Additive genetic factors explained the major proportion (52-74%) of the variation of BMI from 1 to 11 years of age. Environmental factors common to both co-twins also showed some effect (7-28%), but at most ages this was not statistically significant. Strong genetic tracking was found for BMI from 1 to 11 years of age, but there was also evidence for a persistent effect of common environmental factors. Our results suggest that the genetic architecture of BMI development in the Japanese population is generally similar to that found in previous twin studies in Caucasian populations.

journal_name

Behav Genet

journal_title

Behavior genetics

authors

Silventoinen K,Kaprio J,Yokoyama Y

doi

10.1007/s10519-010-9380-y

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

234-41

issue

2

eissn

0001-8244

issn

1573-3297

journal_volume

41

pub_type

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