Abstract:
:Recent studies have identified genes that influence the length of the circadian period maintained by mice housed under constant lighting conditions. However, a less studied circadian activity variable is the amplitude of daily oscillations in locomotor activity. This parameter reflects spontaneous activity exhibited under standard lighting and housing conditions and, therefore, differs conceptually from assessments of exploratory or open-field activity, voluntary wheel-running, or circadian period during exposure to constant light or constant darkness conditions. We recently observed a greater daily amplitude of oscillation in spontaneous locomotor activity in C57BL/6 mice compared to BALB/cBy mice. To identify genetic loci with potential linkage to circadian variation in the amount of locomotor activity, we measured the spontaneous activity of 13 CXB recombinant inbred (RI) strains of mice. The probability density distributions of locomotor activity phenotypes for the 13 CXB RI strains were consistent with the presence of a low number of major quantitative trait loci affecting this trait. Regions of chromosomes 3, 8, 12, 13, and 19 showed provisional linkage to strain variation in locomotor activity. Probabilities of linkage were not sufficient for declaration of an activity-related quantitative trait locus but were sufficient to warrant further analysis either with additional RI strains or with F2 panels.
journal_name
Behav Genetjournal_title
Behavior geneticsauthors
Toth LA,Williams RWdoi
10.1023/a:1021657800287subject
Has Abstractpub_date
1999-09-01 00:00:00pages
319-28issue
5eissn
0001-8244issn
1573-3297journal_volume
29pub_type
杂志文章abstract::The behaviors of male mice of the C57BL/6J (C57), CBA/Lac (CBA) and BALB/c (BALB) strains have been studied in the plus-maze and open field tests for estimation of state anxiety in the stressful novel conditions, and in the cubic box test (exploration of novel cubic box) and the partition test (behavioral reactivity t...
journal_title:Behavior genetics
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1007/s10519-004-1017-6
更新日期:2005-03-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
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更新日期:2015-07-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01071563
更新日期:1994-11-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-008-9238-8
更新日期:2009-01-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01065974
更新日期:1991-07-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-005-2791-5
更新日期:2005-07-01 00:00:00
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journal_title:Behavior genetics
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doi:10.1007/s10519-007-9170-3
更新日期:2008-01-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/a:1023450625826
更新日期:2003-05-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/a:1025601828464
更新日期:1997-05-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2011-01-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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更新日期:1996-07-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
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更新日期:2006-09-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01065699
更新日期:1976-10-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01067713
更新日期:1990-07-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01070816
更新日期:1981-07-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章,评审
doi:10.1007/s10519-019-09950-1
更新日期:2019-05-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-018-9894-2
更新日期:2018-05-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01067187
更新日期:1994-05-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/a:1020880211144
更新日期:2002-11-01 00:00:00