Genetic Tobit factor analysis: quantitative genetic modeling with censored data.

Abstract:

:Parameters of quantitative genetic models have traditionally been estimated by either algebraic manipulation of familial correlations (or familial mean squares), biometric model fitting, or multiple-group covariance structure analysis. With few exceptions, researchers who have used these methods for the analysis of twin data have assumed that their data were multinormal and, consequently, have used normal-theory estimation methods. It is shown that normal-theory methods produce biased genetic and environmental parameter estimates when data are censored. Specifically, with censored data, (1) normal-theory estimates of narrow-sense heritability are either positively or negatively biased, whereas (2) estimates of shared-familial environmental variance are always biased downward. An alternative method for estimating genetic and environmental parameters from censored twin data is proposed. The method is called genetic Tobit factor analysis (GTFA) and is an extension of the Tobit factor analysis model developed by Muthén (Br. J. Math. Stat. Psychol. 42, 241-250, 1989). Using a Monte Carlo design, the performance of GTFA is compared to traditional quantitative genetic methods in both large and small data sets. The results of this study suggest that GTFA is the preferred method for the genetic modeling of censored data obtained from twins.

journal_name

Behav Genet

journal_title

Behavior genetics

authors

Waller NG,Muthén BO

doi

10.1007/BF01066662

subject

Has Abstract

pub_date

1992-05-01 00:00:00

pages

265-92

issue

3

eissn

0001-8244

issn

1573-3297

journal_volume

22

pub_type

杂志文章
  • Genetic and environmental influences on depressive symptoms in Chinese adolescents.

    abstract::Adolescent depression is common and has become a major public health concern in China, yet little research has examined the etiology of depression in Chinese adolescents. In the present study, genetic and environmental influences on Chinese adolescent depressive symptoms were investigated in 1,181 twin pairs residing ...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-013-9632-8

    authors: Chen J,Li X,Natsuaki MN,Leve LD,Harold GT

    更新日期:2014-01-01 00:00:00

  • A proposed heuristic for communicating heritability estimates to the general public, with obesity as an example.

    abstract::It is well established that many continuously distributed traits have a heritable component. However, it is often difficult to communicate to the general public the meaning of quantitative estimates of heritability. To address this problem, the present paper introduces a heuristic for communicating heritability to non...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1023/a:1025670316169

    authors: Allison DB,Faith MS

    更新日期:1997-09-01 00:00:00

  • Sex differences in property crime in a Danish adoption cohort.

    abstract::Sex differences in genetic and environmental influences on criminal behavior against property were studied in a birth cohort of 6129 male and 7065 female Danish adoptees and their biological and adoptive parents. Both genetic and environmental factors were found to contribute to variation in liability to property crim...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/BF01066164

    authors: Baker LA,Mack W,Moffitt TE,Mednick S

    更新日期:1989-05-01 00:00:00

  • Genetic mixed linear models for twin survival data.

    abstract::Twin studies are useful for assessing the relative importance of genetic or heritable component from the environmental component. In this paper we develop a methodology to study the heritability of age-at-onset or lifespan traits, with application to analysis of twin survival data. Due to limited period of observation...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-007-9150-7

    authors: Ha ID,Lee Y,Pawitan Y

    更新日期:2007-07-01 00:00:00

  • Selection for agonistic behavior in wild female mice.

    abstract::This article reports the results of 11 generations of selective breeding for isolation-induced, interfemale aggression in Mus musculus. Within-family selection was used to form two high, two low, and two unselected control lines, beginning with a population of wild-trapped mice. Selection was successful in establishin...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/BF01065597

    authors: Hyde JS,Sawyer TF

    更新日期:1980-07-01 00:00:00

  • An Extended Twin-Pedigree Study of Neuroticism in the Netherlands Twin Register.

    abstract::For the participants in the Netherlands Twin Register (NTR) we constructed the extended pedigrees which specify all relations among nuclear and larger twin families in the register. A total of 253,015 subjects from 58,645 families were linked to each other, to the degree that we had information on the relations among ...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-017-9872-0

    authors: Boomsma DI,Helmer Q,Nieuwboer HA,Hottenga JJ,de Moor MH,van den Berg SM,Davies GE,Vink JM,Schouten MJ,Dolan CV,Willemsen G,Bartels M,van Beijsterveldt TCEM,Ligthart L,de Geus EJ

    更新日期:2018-01-01 00:00:00

  • Individual differences in handedness and specific speech and language impairment: evidence against a genetic link.

    abstract::Data from two twin studies were used to address two related questions. First, is there any association between handedness and specific speech and language impairment (SSLI) in children? Second, is there genetic influence on individual differences in handedness and, if so, are the same genes implicated in the cause of ...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1023/a:1012239617367

    authors: Bishop DV

    更新日期:2001-07-01 00:00:00

  • Multivariate and behavior genetic analysis of avoidance of complex visual stimuli and activity in recombinant inbred strains of mice.

    abstract::Sixty-six mice of 11 genetic stocks (the Bailey recombinant inbred strains CXBD, CXBE, CXBG, CXBH, CXBI, CXBJ, CXBK; their progenitor strains, BALB/cBy and C57BL/6By: and the reciprocal hybrids, B6CF and CB6F) were tested in a two-compartment apparatus and in a shuttlebox, with five measures taken relating to activity...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/BF01066277

    authors: Simmel EC,Eleftheriou BE

    更新日期:1977-05-01 00:00:00

  • Nine generations of selection for high and low nicotine intake in outbred Sprague-Dawley rats.

    abstract::Previous animal studies have revealed significant involvement of genetics in nicotine intake; however, the extent of the genetic contribution to this behavior has not been well addressed. We report the first study of nine generations of selection for high and low voluntary nicotine intake in outbred Sprague-Dawley rat...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-013-9605-y

    authors: Nesil T,Kanit L,Li MD,Pogun S

    更新日期:2013-09-01 00:00:00

  • Quantile-Specific Heritability of Intakes of Alcohol but not Other Macronutrients.

    abstract::Genetic heritability (h2) of alcohol use is reported to be greater in rural dwellers, distressed marriages, low socioeconomic status, in girls who are unmarried or lacking closeness with their parents or religious upbringing, in less-educated men, and in adolescents with peers using alcohol. However, these are all ris...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-020-10005-z

    authors: Williams PT

    更新日期:2020-09-01 00:00:00

  • Handedness in twins according to zygosity and chorion type: a preliminary report.

    abstract::In the course of the East Flanders Prospective Twin Survey (EFPTS), handedness was assessed as part of a genealogical study (Meulemans et al., 1995) in 1616 twins (808 twin pairs) aged 6 to 28. Our findings are that, in this large population-based study with known placentation and zygosity, the often observed higher f...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/BF02359484

    authors: Derom C,Thiery E,Vlietinck R,Loos R,Derom R

    更新日期:1996-07-01 00:00:00

  • Antipredator behavior in paradise fish (Macropodus opercularis) larvae: the role of genetic factors and paternal influence.

    abstract::The paradise fish, a small insectivore, coinhabits marshes of Southeast Asia with several predator fish species. Its ability to recognize and avoid harmful fish may depend upon both genetic factors and experience. Here we demonstrate genetic variability between the 20-day-old larvae of two inbred strains of paradise f...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1023/a:1025601828464

    authors: Miklósi A,Csányi V,Gerlai R

    更新日期:1997-05-01 00:00:00

  • Activity rhythms in inbred mice. I. Genetic analysis with recombinant inbred strains.

    abstract::Rhythm of activity of inbred mice was recorded automatically by a set of actographs. This rhythm was characterized by six indices in the temporal and frequency domains. Two methods of genetic analysis were applied to these indices using parental strains BALB/c and C57BL/6, the reciprocal F1's, and the seven recombinan...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/BF01066331

    authors: Beau J

    更新日期:1991-03-01 00:00:00

  • Frequentist model-averaged estimators and tests for univariate twin models.

    abstract::Parameter estimates from analyses of univariate twin data usually do not reflect the uncertainty due to the model selection phase of the data analysis. To address the effect of model selection uncertainty on parameter estimates, we introduce frequentist model-averaged estimators for univariate twin data analysis that ...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-006-9065-8

    authors: Williams CJ,Christian JC

    更新日期:2006-09-01 00:00:00

  • A genome-wide association study of social and non-social autistic-like traits in the general population using pooled DNA, 500 K SNP microarrays and both community and diagnosed autism replication samples.

    abstract::Two separate genome-wide association studies were conducted to identify single nucleotide polymorphisms (SNPs) associated with social and nonsocial autistic-like traits. We predicted that we would find SNPs associated with social and non-social autistic-like traits and that different SNPs would be associated with soci...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-009-9308-6

    authors: Ronald A,Butcher LM,Docherty S,Davis OS,Schalkwyk LC,Craig IW,Plomin R

    更新日期:2010-01-01 00:00:00

  • Genotype on the pigmentation regulating PMEL17 gene affects behavior in chickens raised without physical contact with conspecifics.

    abstract::Chickens homozygous for the Dominant white or wild-type allele of PMEL17 were subjected to a broad phenotyping in order to detect consistent differences between genotypes. To exclude feather pecking, the chickens were individually housed without physical contact, from the day of hatching, and tested for social, aggres...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-010-9379-4

    authors: Karlsson AC,Mormede P,Kerje S,Jensen P

    更新日期:2011-03-01 00:00:00

  • Multiple raters of disruptive child behavior: using a genetic strategy to examine shared views and bias.

    abstract::Most research on child behavior incorporates information from different individuals. While agreement between informants is generally only modest, there is little understanding of the processes underlying disagreement. In twin studies, differential agreement among raters for MZ and DZ twins is of particular concern. Th...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/BF02197280

    authors: Simonoff E,Pickles A,Hewitt J,Silberg J,Rutter M,Loeber R,Meyer J,Neale M,Eaves L

    更新日期:1995-07-01 00:00:00

  • Genetic and environmental mediation between measures of personality and family environment in twins reared together.

    abstract::In this study we analyzed the etiology of the relationship between personality traits and retrospectively recalled family environment. The data of 226 identical and 168 fraternal twin pairs reared together from the Jena twin study of social attitudes were available. Personality traits were measured using the self- and...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-008-9238-8

    authors: Kandler C,Riemann R,Kämpfe N

    更新日期:2009-01-01 00:00:00

  • Examination of genetic variation in GABRA2 with conduct disorder and alcohol abuse and dependence in a longitudinal study.

    abstract::Previous studies have shown associations between single nucleotide polymorphisms (SNPs) in gamma aminobutyric acid receptor alpha 2 (GABRA2) and adolescent conduct disorder (CD) and alcohol dependence in adulthood, but not adolescent alcohol dependence. The present study was intended as a replication and extension of ...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-014-9653-y

    authors: Melroy WE,Stephens SH,Sakai JT,Kamens HM,McQueen MB,Corley RP,Stallings MC,Hopfer CJ,Krauter KS,Brown SA,Hewitt JK,Ehringer MA

    更新日期:2014-07-01 00:00:00

  • The linkage map of the rat.

    abstract::Our genetic knowledge of a species is reflected in the state of its gene map. Although still primitive, relative to the gene map of the mouse, great strides have been made in recent years in developing the gene map of the rat and nine linkage groups have now been defined. Mapping by conventional backcrossing methods h...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/BF01070002

    authors: Womack JE

    更新日期:1981-09-01 00:00:00

  • QTL analysis of a red junglefowl x White Leghorn intercross reveals trade-off in resource allocation between behavior and production traits.

    abstract::Behaviors with high energetic costs may decrease in frequency in domestic animals as a response to selection for increased production. The aim of this study was to quantify production traits, foraging behavior, and social motivation in F2 progeny from a White Leghorn x red junglefowl intercross (n = 751-1046) and to p...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1023/a:1020880211144

    authors: Schütz K,Kerje S,Carlborg O,Jacobsson L,Andersson L,Jensen P

    更新日期:2002-11-01 00:00:00

  • Twin analysis on paired comparison data.

    abstract::Current behavior genetic models can only employ limited types of phenotypic data, such as Likert scale data or continuous data, as variables. Here, a new method employing paired comparison data is presented within the framework of behavior genetic models. This model facilitates the estimation of genetic, shared enviro...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-007-9183-y

    authors: Ozaki K

    更新日期:2008-03-01 00:00:00

  • Spatial memory of heterozygous staggerer (Rora(+)/Rora(sg)) versus normal (Rora(+)/Rora(+)) mice during aging.

    abstract::Heterozygous staggerer mice (Rora(+)/Rora(sg)) and control mice (Rora(+)/Rora(+)) of the same C57BL/6J strain background were tested in a spontaneous alternation task at 3 to 24 months old. The results demonstrated a decrement in long-term working memory as early as 6 months in Rora(+)/Rora(+) mice and at 3 months in ...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1023/B:BEGE.0000017875.78571.a6

    authors: Caston J,Chianale C,Mariani J

    更新日期:2004-05-01 00:00:00

  • Family matters: happiness in nuclear families and twins.

    abstract::Biometric studies have shown that happiness is strongly affected by genes. The findings are mainly based on twin data, however, and the full validity of the results has been debated. To overcome some limitations in classical twin research, we examined aetiological sources of subjective well-being (SWB), using two inde...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-010-9365-x

    authors: Nes RB,Czajkowski N,Tambs K

    更新日期:2010-09-01 00:00:00

  • Forward Genetic Screening Using Behavioral Tests in Zebrafish: A Proof of Concept Analysis of Mutants.

    abstract::The zebrafish enjoys several advantages over other model organisms. It is small, easy to maintain, prolific, and numerous genetic tools are available for it. For example, forward genetic screens have allowed investigators to identify important genes potentially involved in a variety of functions from embryogenesis to ...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-016-9818-y

    authors: Gerlai R,Poshusta TL,Rampersad M,Fernandes Y,Greenwood TM,Cousin MA,Klee EW,Clark KJ

    更新日期:2017-01-01 00:00:00

  • Human parental behavior: evidence for genetic influence and potential implication for gene-culture transmission.

    abstract::A large sample of adult twins (1117 pairs), who were concordant for having had children were asked to report on their child-rearing practices. A 14-item version of the Parental Bonding Instrument (PBI) was used to assess rearing practices of parent twins. The two factors of Care and Overprotection, commonly found in o...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/BF01067533

    authors: Pérusse D,Neale MC,Heath AC,Eaves LJ

    更新日期:1994-07-01 00:00:00

  • Oligogenic determination of morphine analgesic magnitude: a genetic analysis of selectively bred mouse lines.

    abstract::Two ongoing selective breeding projects have produced mice that display divergent analgesic responses to morphine. These two projects have selected for similar phenotypes: high and low levorphanol analgesia (HAR/LAR lines; Portland, OR) and high and low swim stress-induced analgesia (HA/LA lines; Jastrzebiec, Poland)....

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/BF02197290

    authors: Mogil JS,Flodman P,Spence MA,Sternberg WF,Kest B,Sadowski B,Liebeskind JC,Belknap JK

    更新日期:1995-07-01 00:00:00

  • In search of the perfect phenotype: an analysis of linkage and association studies of reading and reading-related processes.

    abstract::Reading ability and specific reading disability (SRD) are complex traits involving several cognitive processes and are shaped by a complex interplay of genetic and environmental forces. Linkage studies of these traits have identified several susceptibility loci. Association studies have gone further in detecting candi...

    journal_title:Behavior genetics

    pub_type: 杂志文章,评审

    doi:10.1007/s10519-011-9444-7

    authors: Skiba T,Landi N,Wagner R,Grigorenko EL

    更新日期:2011-01-01 00:00:00

  • A comparison of the contribution of the major histocompatibility complex (MHC) and Y chromosomes to the discriminability of individual urine odors of mice by Long-Evans rats.

    abstract::A go/no-go operant task was used to assess the ability of male Long-Evans rats to discriminate between the urine odors from pairs of intact MHC congenic mice (C57BL/6-H-2Kb/J and C57BL/6-H-2Kbm1/ByJ), intact Y congenic mice (DBA1 and DBA1.C57BL10-Y), and castrated Y congenic mice of these two strains. The MHC congenic...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/BF01082464

    authors: Schellinck HM,Monahan E,Brown RE,Maxson SC

    更新日期:1993-05-01 00:00:00

  • Absence of an association between motor coordination and spatial orientation in lurcher mutant mice.

    abstract::Lurcher mutant mice were impaired in spatial orientation and motor coordination in comparison to normal mice. Both groups improved across days in both invisible and visible water maze platform conditions. Contrary to normal mice, lurcher mutants did not improve over days in terms of the time taken to reach a side-bar ...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/BF01071563

    authors: Lalonde R,Thifault S

    更新日期:1994-11-01 00:00:00