Absence of an association between motor coordination and spatial orientation in lurcher mutant mice.

Abstract:

:Lurcher mutant mice were impaired in spatial orientation and motor coordination in comparison to normal mice. Both groups improved across days in both invisible and visible water maze platform conditions. Contrary to normal mice, lurcher mutants did not improve over days in terms of the time taken to reach a side-bar in a motor coordination test, an indication of defective motor learning. However, lurchers were able to stay on the bar longer across days. These results indicate that motor learning deficits in this cerebellar-damaged animal are not absolute but dependent on the type of measurement attempted. There was no correlation between motor coordination and spatial orientation for normal mice. A similar absence of correlation was noted for lurcher mutants, except for falling latencies in the coat-hanger test during the middle of training.

journal_name

Behav Genet

journal_title

Behavior genetics

authors

Lalonde R,Thifault S

doi

10.1007/BF01071563

subject

Has Abstract

pub_date

1994-11-01 00:00:00

pages

497-501

issue

6

eissn

0001-8244

issn

1573-3297

journal_volume

24

pub_type

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