Abstract:
:Two separate genome-wide association studies were conducted to identify single nucleotide polymorphisms (SNPs) associated with social and nonsocial autistic-like traits. We predicted that we would find SNPs associated with social and non-social autistic-like traits and that different SNPs would be associated with social and nonsocial. In Stage 1, each study screened for allele frequency differences in approximately 430,000 autosomal SNPs using pooled DNA on microarrays in high-scoring versus low-scoring boys from a general population sample (N = approximately 400/group). In Stage 2, 22 and 20 SNPs in the social and non-social studies, respectively, were tested for QTL association by individually genotyping an independent community sample of 1,400 boys. One SNP (rs11894053) was nominally associated (P < .05, uncorrected for multiple testing) with social autistic-like traits. When the sample was increased by adding females, 2 additional SNPs were nominally significant (P < .05). These 3 SNPs, however, showed no significant association in transmission disequilibrium analyses of diagnosed ASD families.
journal_name
Behav Genetjournal_title
Behavior geneticsauthors
Ronald A,Butcher LM,Docherty S,Davis OS,Schalkwyk LC,Craig IW,Plomin Rdoi
10.1007/s10519-009-9308-6subject
Has Abstractpub_date
2010-01-01 00:00:00pages
31-45issue
1eissn
0001-8244issn
1573-3297journal_volume
40pub_type
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journal_title:Behavior genetics
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01065677
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01065679
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journal_title:Behavior genetics
pub_type: 杂志文章
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doi:10.1007/s10519-020-10005-z
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pub_type: 杂志文章
doi:10.1007/s10519-010-9365-x
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-006-9065-8
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doi:10.1023/a:1025607107566
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