Abstract：
:Parameter estimates from analyses of univariate twin data usually do not reflect the uncertainty due to the model selection phase of the data analysis. To address the effect of model selection uncertainty on parameter estimates, we introduce frequentist model-averaged estimators for univariate twin data analysis that use information-theoretic criteria to assign model weights. We conduct simulation studies to examine the performance of model-averaged estimators of additive genetic variance, and for tests for additive genetic variance based on model-averaged estimators. In simulation studies with small or moderate sample sizes, model-averaged estimators of additive genetic variance typically have lower mean-squared error than either (i) estimators from individual twin models, or (ii) estimators obtained from a decision procedure where the best-fitting model from likelihood-ratio testing is used to estimate additive genetic variance. For each sample size simulated, bootstrap tests based on model-averaged estimators have higher power to detect additive genetic variance than currently-used tests in most cases.
journal_name
Behav Genetjournal_title
Behavior geneticsauthors
Williams CJ,Christian JCdoi
10.1007/s10519-006-9065-8subject
Has Abstractpub_date
2006-09-01 00:00:00pages
687-96issue
5eissn
0001-8244issn
1573-3297journal_volume
36pub_type
杂志文章abstract：:Variance components analysis provides an efficient method for performing linkage analysis for quantitative traits. However, power and type 1 error of variance components-based likelihood ratio testing may be affected when phenotypic data are nonnormally distributed (especially with high values of kurtosis) and there i...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/B:BEGE.0000013729.26354.da
更新日期：2004-03-01 00:00:00
abstract：:Reading ability and specific reading disability (SRD) are complex traits involving several cognitive processes and are shaped by a complex interplay of genetic and environmental forces. Linkage studies of these traits have identified several susceptibility loci. Association studies have gone further in detecting candi...
journal_title：Behavior genetics
pub_type： 杂志文章,评审
doi：10.1007/s10519-011-9444-7
更新日期：2011-01-01 00:00:00
abstract：:Genetic strains of mice represent an important resource for research on the biological determinants of complex diseases and behavioral phenotypes. To date, the approaches used have had little success in identifying causal genes. We have evaluated brain gene expression in C57BL/6J (B6) and DBA/2J (D2) inbred mouse stra...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/B:BEGE.0000023648.78190.ee
更新日期：2004-07-01 00:00:00
abstract：:A model of handedness incorporating both genetic and cultural processes is proposed, based on an evolutionary analysis, and maximum-likelihood estimates of its parameters are generated. This model has the characteristics that (i) no genetic variation underlies variation in handedness, and (ii) variation in handedness ...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF02253372
更新日期：1995-09-01 00:00:00
abstract：:Recent substantive research on biometric analyses of twin and family data has used both a biometric path analysis model (PAM) and a biometric variance components model (VCM). Methodological research on these same topics have suggested benefits of using linear structural equation model algorithms (SEMA) as well as mixe...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-005-2868-1
更新日期：2005-09-01 00:00:00
abstract：:Parameters of quantitative genetic models have traditionally been estimated by either algebraic manipulation of familial correlations (or familial mean squares), biometric model fitting, or multiple-group covariance structure analysis. With few exceptions, researchers who have used these methods for the analysis of tw...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01066662
更新日期：1992-05-01 00:00:00
abstract：:In the original version of this article, unfortunately, in the acknowledgement section "National Institutes of Health (NIH, R37 AG033590-08) to J Cacioppo" was omitted. This has been corrected by publishing this erratum. ...
journal_title：Behavior genetics
pub_type： 已发布勘误
doi：10.1007/s10519-019-09956-9
更新日期：2019-05-01 00:00:00
abstract：:Structural equation modeling (SEM) provides a flexible tool to carry out genetic analyses of family and twin data. The basic model which decomposes the variance between and within families for a particular trait into genetic and non-genetic components can be generalized to multivariate and/or longitudinal data, incorp...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-005-2791-5
更新日期：2005-07-01 00:00:00
abstract：:Selective breeding for initial sensitivity to ethanol has been carried out by a number of investigators in order to investigate the mechanisms by which ethanol brings about a myriad of effects on the mammalian central nervous system. In addition the availability of these selectively bred animals provides clues to the ...
journal_title：Behavior genetics
pub_type： 杂志文章,评审
doi：10.1007/BF01067420
更新日期：1993-03-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-005-3217-0
更新日期：2005-05-01 00:00:00
abstract：:The zebrafish enjoys several advantages over other model organisms. It is small, easy to maintain, prolific, and numerous genetic tools are available for it. For example, forward genetic screens have allowed investigators to identify important genes potentially involved in a variety of functions from embryogenesis to ...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-016-9818-y
更新日期：2017-01-01 00:00:00
abstract：:Elucidating the causes of population divergence, and ultimately speciation, is a central objective of evolutionary biology. A number of previous studies of Drosophila populations from the Nahal Oren canyon (Mt Carmel, Israel) revealed significant interslope differences for a complex of fitness and behavioral traits. P...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-005-6119-2
更新日期：2005-11-01 00:00:00
abstract：:Cannabis use is linked to positive and negative outcomes. Identifying genetic targets of susceptibility to the negative effects of cannabinoid use is of growing importance. The current study sought to complete short-term selective breeding for adolescent sensitivity and resistance to the locomotor effects of a single ...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-018-9894-2
更新日期：2018-05-01 00:00:00
abstract：:Common SNPs in nicotinic acetylcholine receptor genes (CHRN genes) have been associated with drug behaviors and personality traits, but the influence of rare genetic variants is not well characterized. The goal of this project was to identify novel rare variants in CHRN genes in the Center for Antisocial Drug Dependen...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-016-9792-4
更新日期：2016-09-01 00:00:00
abstract：:For the participants in the Netherlands Twin Register (NTR) we constructed the extended pedigrees which specify all relations among nuclear and larger twin families in the register. A total of 253,015 subjects from 58,645 families were linked to each other, to the degree that we had information on the relations among ...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-017-9872-0
更新日期：2018-01-01 00:00:00
abstract：:The goal of the present study is to examine genetic and environmental influences on maternal and teacher ratings of Attention Problems (AP) in 7-year-old children. Teachers completed the Teacher Report Form (N=2259 pairs), and mothers the Child Behavior Checklist (N=2057 pairs). Higher correlations were found in twins...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-006-9084-5
更新日期：2006-11-01 00:00:00
abstract：:Genome wide complex trait analysis (GCTA) is extended to include environmental effects of the maternal genotype on offspring phenotype ("maternal effects", M-GCTA). The model includes parameters for the direct effects of the offspring genotype, maternal effects and the covariance between direct and maternal effects. A...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-014-9666-6
更新日期：2014-09-01 00:00:00
abstract：:Manipulation of endogenous levels of the GABAergic neurosteroid allopregnanolone alters sensitivity to some effects of ethanol. Chronic ethanol withdrawal decreases activity and expression of 5α-reductase-1, an important enzyme in allopregnanolone biosynthesis encoded by the 5α-reductase-1 gene (Srd5a1). The present s...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-014-9691-5
更新日期：2015-05-01 00:00:00
abstract：:In studies of child psychopathology, phenotypes of interest are often obtained by parental ratings. When behavioral ratings are obtained in the context of a twin study, this allows for the decomposition of the phenotypic variance, into a genetic and a non-genetic part. If a phenotype is assessed by a single rater, her...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-016-9823-1
更新日期：2017-03-01 00:00:00
abstract：:The paradise fish, a small insectivore, coinhabits marshes of Southeast Asia with several predator fish species. Its ability to recognize and avoid harmful fish may depend upon both genetic factors and experience. Here we demonstrate genetic variability between the 20-day-old larvae of two inbred strains of paradise f...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/a:1025601828464
更新日期：1997-05-01 00:00:00
abstract：:A model based on the latent class model is developed for the effects of genes and environment on multivariate categorical data in twins. The model captures many essential features of dimensional and categorical conceptions of complex behavioral phenotypes and can include, as special cases, a variety of major locus mod...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01067550
更新日期：1993-01-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-007-9183-y
更新日期：2008-03-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-016-9831-1
更新日期：2017-03-01 00:00:00
abstract：:Anxiety disorders are phenotypically complex and may involve multiple genetic influences on many neurotransmitter systems. Rodent tests used to investigate genetic influences on anxiety-like phenotypes have face and predictive validity as models for anxiety in humans. If multiple genes contribute additively to a trait...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/B:BEGE.0000009479.02183.1f
更新日期：2004-01-01 00:00:00
abstract：:Male Drosophila melanogaster from lines artificially selected to have divergent life histories were tested to determine if they differed in their effects on female reproductive behavior. During the first 5 days after mating, males from short-generation populations caused females to lay eggs at a faster rate than did m...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF02361157
更新日期：1996-01-01 00:00:00
abstract：:A genome-wide linkage scan of 795 microsatellite markers (761 autosomal, 34 X chromosome) was performed on Multidimensional Aptitude Battery subtests and verbal, performance and full scale scores, the WAIS-R Digit Symbol subtest, and two word-recognition tests (Schonell Graded Word Reading Test, Cambridge Contextual R...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-005-9003-1
更新日期：2006-01-01 00:00:00
abstract：:Reading difficulties are both heritable and stable; however, little is known about the etiology of this stability. Results from a preliminary analysis of data from 56 twin pairs who participated in the Colorado Longitudinal Twin Study of Reading Disability (Astrom et al., Twin Res Hum Genet 10:434-439, 2007) suggested...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-011-9445-6
更新日期：2011-09-01 00:00:00
abstract：:Artificial selection was used to establish different levels of agonistic behavior in laboratory-reared wild female Mus musculus. A within-family selection design with replicated high and low lines and two nonselected control lines was employed. Females only were tested at 8 weeks of age on 2 consecutive days. Testing ...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01065725
更新日期：1976-07-01 00:00:00
abstract：:A complimentary two-phase strategy was used to detect and map quantitative trait loci (QTLs) associated with the basal locomotor response to a saline challenge (10 ml/kg). In phase 1, putative QTLs, significant at p < 0.01 or better, were identified by analysis of the strain means for 25 strains of the B x D recombina...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/a:1001963906258
更新日期：2000-05-01 00:00:00
abstract：:The heritability of human personality is well-established. Recent research indicates that nonadditive genetic effects, such as dominance and epistasis, play a large role in personality variation. One possible explanation for the latter finding is that there has been recent selection on human personality. To test this ...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-012-9537-y
更新日期：2012-07-01 00:00:00
