Frequentist model-averaged estimators and tests for univariate twin models.


:Parameter estimates from analyses of univariate twin data usually do not reflect the uncertainty due to the model selection phase of the data analysis. To address the effect of model selection uncertainty on parameter estimates, we introduce frequentist model-averaged estimators for univariate twin data analysis that use information-theoretic criteria to assign model weights. We conduct simulation studies to examine the performance of model-averaged estimators of additive genetic variance, and for tests for additive genetic variance based on model-averaged estimators. In simulation studies with small or moderate sample sizes, model-averaged estimators of additive genetic variance typically have lower mean-squared error than either (i) estimators from individual twin models, or (ii) estimators obtained from a decision procedure where the best-fitting model from likelihood-ratio testing is used to estimate additive genetic variance. For each sample size simulated, bootstrap tests based on model-averaged estimators have higher power to detect additive genetic variance than currently-used tests in most cases.


Behav Genet


Behavior genetics


Williams CJ,Christian JC




Has Abstract


2006-09-01 00:00:00












  • Longitudinal analyses of the determinants of drinking and of drinking to intoxication in adolescent twins.

    abstract::Genetic and environmental determinants of self-reported alcohol consumption were investigated in a sample of 2513 twin pairs who were first assessed at age 16 and were followed-up at age 17. At age 16, 77% of the sample was drinking, and 65% of drinkers reported drinking to intoxication. Both drinking and drinking to ...

    journal_title:Behavior genetics

    pub_type: 杂志文章


    authors: Viken RJ,Kaprio J,Koskenvuo M,Rose RJ

    更新日期:1999-11-01 00:00:00

  • The genetics of cognitive processes: candidate genes in humans and animals.

    abstract::It has been hypothesized that numerous genes contribute to individual variation in human cognition. An extensive search of the scientific literature was undertaken to identify candidate genes which might contribute to this complex trait. A list of over 150 candidate genes that may influence some aspect of cognition wa...

    journal_title:Behavior genetics

    pub_type: 杂志文章,评审


    authors: Morley KI,Montgomery GW

    更新日期:2001-11-01 00:00:00

  • Gender-specific gene-environment interaction in alcohol dependence: the impact of daily life events and GABRA2.

    abstract::Gender-moderated gene-environment interactions are rarely explored, raising concerns about inaccurate specification of etiological models and inferential errors. The current study examined the influence of gender, negative and positive daily life events, and GABRA2 genotype (SNP rs279871) on alcohol dependence, testin...

    journal_title:Behavior genetics

    pub_type: 杂志文章


    authors: Perry BL,Pescosolido BA,Bucholz K,Edenberg H,Kramer J,Kuperman S,Schuckit MA,Nurnberger JI Jr

    更新日期:2013-09-01 00:00:00

  • Genetic variance in a component of the language acquisition device: ROBO1 polymorphisms associated with phonological buffer deficits.

    abstract::The region containing ROBO1 (Chromosome 3p12.3) has been implicated as a susceptibility gene for reading disorder and language deficit by translocation and linkage data. No association studies have yet been reported supporting any candidate gene. Here we report the first association of this gene with language deficits...

    journal_title:Behavior genetics

    pub_type: 杂志文章


    authors: Bates TC,Luciano M,Medland SE,Montgomery GW,Wright MJ,Martin NG

    更新日期:2011-01-01 00:00:00

  • Differences between two psychogenetically selected lines of rats in a swimming pool matching-to-place task: long-term effects of infantile stimulation.

    abstract::The present study explored the effects of infantile stimulation (i.e., neonatal handling or NH) on the performance of 18-month-old Roman high-avoidance (RHA/Verh) and low-avoidance (RLA/Verh) rats in a swimming pool matching-to-place (SPMP) test. This test (also called repeated acquisition and place learning-set parad...

    journal_title:Behavior genetics

    pub_type: 杂志文章


    authors: Aguilar R,Escorihuela RM,Gil L,Tobeña A,Fernández-Teruel A

    更新日期:2002-03-01 00:00:00

  • Marriage and genetic variation across the lifespan: not a steady relationship?

    abstract::The prevalence of marriage varies across the lifespan, as does its importance to reproduction and the nurturance of children. We examined genetic and environmental influences on self-reported marriage at each decade from 20 through 70 years of age, using data collected for the Duke Dementia Study, a followed-up subset...

    journal_title:Behavior genetics

    pub_type: 杂志文章


    authors: Trumbetta SL,Markowitz EM,Gottesman II

    更新日期:2007-03-01 00:00:00

  • Handedness in twins according to zygosity and chorion type: a preliminary report.

    abstract::In the course of the East Flanders Prospective Twin Survey (EFPTS), handedness was assessed as part of a genealogical study (Meulemans et al., 1995) in 1616 twins (808 twin pairs) aged 6 to 28. Our findings are that, in this large population-based study with known placentation and zygosity, the often observed higher f...

    journal_title:Behavior genetics

    pub_type: 杂志文章


    authors: Derom C,Thiery E,Vlietinck R,Loos R,Derom R

    更新日期:1996-07-01 00:00:00

  • Genetic differences in learning behavior in honeybees (Apis mellifera capensis).

    abstract::Workers from colonies of Cape honeybees show marked phenotypic differences in performance in proboscis extension reflex (PER) conditioning. Analysis of these differences using parthenogenetic offspring groups permitted the estimation of genotypic values and revealed a high degree of genetic variability that is evident...

    journal_title:Behavior genetics

    pub_type: 杂志文章


    authors: Brandes C

    更新日期:1991-05-01 00:00:00

  • Genetic Tobit factor analysis: quantitative genetic modeling with censored data.

    abstract::Parameters of quantitative genetic models have traditionally been estimated by either algebraic manipulation of familial correlations (or familial mean squares), biometric model fitting, or multiple-group covariance structure analysis. With few exceptions, researchers who have used these methods for the analysis of tw...

    journal_title:Behavior genetics

    pub_type: 杂志文章


    authors: Waller NG,Muthén BO

    更新日期:1992-05-01 00:00:00

  • Short-Term Genetic Selection for Adolescent Locomotor Sensitivity to Delta9-Tetrahydrocannabinol (THC).

    abstract::Cannabis use is linked to positive and negative outcomes. Identifying genetic targets of susceptibility to the negative effects of cannabinoid use is of growing importance. The current study sought to complete short-term selective breeding for adolescent sensitivity and resistance to the locomotor effects of a single ...

    journal_title:Behavior genetics

    pub_type: 杂志文章


    authors: Kasten CR,Zhang Y,Mackie K,Boehm SL 2nd

    更新日期:2018-05-01 00:00:00

  • The case of The Case of the Midwife Toad.

    abstract::The facts concerning Kammerer's case are reviewed. Koestler's view that Krammerer was unjustly accused is presented and shown to be incorrect. ...

    journal_title:Behavior genetics

    pub_type: 传,历史文章,杂志文章


    authors: Aronson LR

    更新日期:1975-04-01 00:00:00

  • Evidence for Association Between Low Frequency Variants in CHRNA6/CHRNB3 and Antisocial Drug Dependence.

    abstract::Common SNPs in nicotinic acetylcholine receptor genes (CHRN genes) have been associated with drug behaviors and personality traits, but the influence of rare genetic variants is not well characterized. The goal of this project was to identify novel rare variants in CHRN genes in the Center for Antisocial Drug Dependen...

    journal_title:Behavior genetics

    pub_type: 杂志文章


    authors: Kamens HM,Corley RP,Richmond PA,Darlington TM,Dowell R,Hopfer CJ,Stallings MC,Hewitt JK,Brown SA,Ehringer MA

    更新日期:2016-09-01 00:00:00

  • Genetic analysis of differences in behavioral reactivity to neonatal injection of testosterone in female mice.

    abstract::A genetic analysis of differences in reactivity to early exposure of female BALB/cBy and C57BL/6By mice to testosterone was performed using the C x B recombinant-inbred (RI) strains. RI female mice were given a single injection of 1 mg of testosterone propionate on day 4 of life and observed in adulthood in the presen...

    journal_title:Behavior genetics

    pub_type: 杂志文章


    authors: Michard-Vanhée C,Roubertoux P

    更新日期:1990-01-01 00:00:00

  • Identification and time dependence of quantitative trait loci for basal locomotor activity in the BXD recombinant inbred series and a B6D2 F2 intercross.

    abstract::A complimentary two-phase strategy was used to detect and map quantitative trait loci (QTLs) associated with the basal locomotor response to a saline challenge (10 ml/kg). In phase 1, putative QTLs, significant at p < 0.01 or better, were identified by analysis of the strain means for 25 strains of the B x D recombina...

    journal_title:Behavior genetics

    pub_type: 杂志文章


    authors: Koyner J,Demarest K,McCaughran J Jr,Cipp L,Hitzemann R

    更新日期:2000-05-01 00:00:00

  • Body fat in identical twins reared apart: roles for genes and environment.

    abstract::We report analyses of data on body fat from a cohort of 34 separated monozygotic twin pairs (MZA) and a matched sample of 38 pairs of monozygotic twins reared together (MZT) originally studied by James Shields. The correlation for MZA pairs was .61 and the correlation for MZT pairs was .75. These correlations did not ...

    journal_title:Behavior genetics

    pub_type: 杂志文章


    authors: Price RA,Gottesman II

    更新日期:1991-01-01 00:00:00

  • Diagnosis of zygosity by questionnaire and polymarker polymerase chain reaction in young twins.

    abstract::We developed a zygosity questionnaire for use in young twins and assessed its validity using the results of DNA diagnosis. The participants were divided into two groups: 105 pairs of adolescent twins (12-16 years old), 47 pairs of child twins (2-12 years old), and their respective parents. The DNA diagnosis of zygosit...

    journal_title:Behavior genetics

    pub_type: 杂志文章


    authors: Chen WJ,Chang HW,Wu MZ,Lin CC,Chang C,Chiu YN,Soong WT

    更新日期:1999-03-01 00:00:00

  • Sex differences in spatial ability in children.

    abstract::There is considerable evidence that sex differences in spatial ability exist in adults, with males outperforming females at every age after puberty. It is difficult, however, to find sex differences in children younger than 13. This is due in part to the lack of adequate measures of spatial ability for use with childr...

    journal_title:Behavior genetics

    pub_type: 杂志文章


    authors: Kerns KA,Berenbaum SA

    更新日期:1991-07-01 00:00:00

  • Type I and type II error rates for quantitative trait loci (QTL) mapping studies using recombinant inbred mouse strains.

    abstract::Effective mapping strategies for quantitative trains must allow for the detection of the more important quantitative trait loci (QTLs) while minimizing false positives. Type I (false-positive) and Type II (false-negative) error rates were estimated from a computer simulation of QTL mapping in the BXD recombinant inbre...

    journal_title:Behavior genetics

    pub_type: 杂志文章


    authors: Belknap JK,Mitchell SR,O'Toole LA,Helms ML,Crabbe JC

    更新日期:1996-03-01 00:00:00

  • Differential genetic etiology of reading component processes as a function of IQ.

    abstract::Results obtained from previous studies of word recognition, reading component skills, and reading composite measures suggest that genetic factors may be more important as a cause for reading disability among children with higher IQ scores than among those with lower IQ scores. To investigate the genetic etiology of re...

    journal_title:Behavior genetics

    pub_type: 杂志文章


    authors: Knopik VS,Smith SD,Cardon L,Pennington B,Gayan J,Olson RK,DeFries JC

    更新日期:2002-05-01 00:00:00

  • Quantile-Specific Heritability of Intakes of Alcohol but not Other Macronutrients.

    abstract::Genetic heritability (h2) of alcohol use is reported to be greater in rural dwellers, distressed marriages, low socioeconomic status, in girls who are unmarried or lacking closeness with their parents or religious upbringing, in less-educated men, and in adolescents with peers using alcohol. However, these are all ris...

    journal_title:Behavior genetics

    pub_type: 杂志文章


    authors: Williams PT

    更新日期:2020-09-01 00:00:00

  • Genetic and environmental influences on child reports of manifest anxiety and symptoms of separation anxiety and overanxious disorders: a community-based twin study.

    abstract::Genetic and environmental influences in the determination of individual differences in self-reported symptoms of separation anxiety (SAD), overanxious disorder (OAD), and manifest anxiety (MANX) were evaluated in children and adolescents for three age groups (8-10, 11-13, and 14-16). Symptom counts for SAD and OAD wer...

    journal_title:Behavior genetics

    pub_type: 杂志文章


    authors: Topolski TD,Hewitt JK,Eaves LJ,Silberg JL,Meyer JM,Rutter M,Pickles A,Simonoff E

    更新日期:1997-01-01 00:00:00

  • Estimating effect sizes in genome-wide association studies.

    abstract::Knowledge about the proportion of markers without effects (p( 0 )) and the effect sizes in large scale genetic studies is important to understand the basic properties of the data and for applications such as the control of false discoveries and designing adequately powered replication studies. Many p(0) estimators hav...

    journal_title:Behavior genetics

    pub_type: 杂志文章


    authors: Bukszár J,van den Oord EJ

    更新日期:2010-05-01 00:00:00

  • The Burt controversy: a comparison of Burt's data on IQ with data from other studies.

    abstract::A recent controversy has given reason to examine the place of Burt's data among other behavioral genetic data on IQ. Although Burt's kinship correlations are higher than the average of other studies, his results are generally consistent with other data. ...

    journal_title:Behavior genetics

    pub_type: 杂志文章


    authors: Rowe D,Plomin R

    更新日期:1978-01-01 00:00:00

  • Calculating Power to Detect Maternal and Offspring Genetic Effects in Genetic Association Studies.

    abstract::Offspring outcomes are a function of maternal genetics operating on the intrauterine and postnatal environment, offspring genetics and environmental factors. Partitioning genetic effects into maternal and offspring components requires genotyped mother-offspring pairs or genotyped individuals with phenotypic informatio...

    journal_title:Behavior genetics

    pub_type: 杂志文章


    authors: Moen GH,Hemani G,Warrington NM,Evans DM

    更新日期:2019-05-01 00:00:00

  • Contributions of genes and environments to stability and change in externalizing and internalizing problems during elementary and middle school.

    abstract::We examined longitudinally collected behavioral reports by teachers on a unique twin sample at the ages of 7, 8, 9, 10, 11, and 12 years. As twin and adoption studies implicate the role of genetic influence on behavioral problems found to be stable in epidemiological samples, the current study employs a developmental ...

    journal_title:Behavior genetics

    pub_type: 杂志文章


    authors: Haberstick BC,Schmitz S,Young SE,Hewitt JK

    更新日期:2005-07-01 00:00:00

  • Social aggregations in cattle. I. Segregation by breed in free-ranging herds.

    abstract::Social aggregations of free-ranging cattle were studied in the Sonoran Desert of Mexico. Cows reared with animals of their own breed in isolation from other breeds maintained segregated social groups. Cows raised together in a mixed herd containing other breeds allied themselves with herd-mates regardless of breed. Ca...

    journal_title:Behavior genetics

    pub_type: 杂志文章


    authors: Murphey RM

    更新日期:1990-05-01 00:00:00

  • Family matters: happiness in nuclear families and twins.

    abstract::Biometric studies have shown that happiness is strongly affected by genes. The findings are mainly based on twin data, however, and the full validity of the results has been debated. To overcome some limitations in classical twin research, we examined aetiological sources of subjective well-being (SWB), using two inde...

    journal_title:Behavior genetics

    pub_type: 杂志文章


    authors: Nes RB,Czajkowski N,Tambs K

    更新日期:2010-09-01 00:00:00

  • Assortative mating in Drosophila adapted to a microsite ecological gradient.

    abstract::Elucidating the causes of population divergence, and ultimately speciation, is a central objective of evolutionary biology. A number of previous studies of Drosophila populations from the Nahal Oren canyon (Mt Carmel, Israel) revealed significant interslope differences for a complex of fitness and behavioral traits. P...

    journal_title:Behavior genetics

    pub_type: 杂志文章


    authors: Singh SR,Rashkovetsky E,Iliadi K,Nevo E,Korol A

    更新日期:2005-11-01 00:00:00

  • The mental rotation task performance of Turner syndrome subjects.

    abstract::Thirty-one female subjects with Turner syndrome (TS) and 31 normal females matched for age and verbal IQ were given a spatial task requiring the mental rotation of geometric figures. The results revealed a poorer performance by the TS group for most items involving rotations. The relationship between reaction time and...

    journal_title:Behavior genetics

    pub_type: 杂志文章


    authors: Rovet J,Netley C

    更新日期:1980-09-01 00:00:00

  • Combined linkage and association analyses of the 124-bp allele of marker D2S2944 with anxiety, depression, neuroticism and major depression.

    abstract::A central issue in psychiatric genetics is whether positive findings replicate. Zubenko et al. (2002b, Mol. Psychiatry 7:460-467) reported an association of the 124-bp allele of D2S2944 with recurrent early-onset major depression for females. We tested for association of this allele to continuous measures of anxiety, ...

    journal_title:Behavior genetics

    pub_type: 杂志文章,多中心研究


    authors: Beem AL,Geus EJ,Hottenga JJ,Sullivan PF,Willemsen G,Slagboom PE,Boomsma DI

    更新日期:2006-01-01 00:00:00