Abstract:
:Effective mapping strategies for quantitative trains must allow for the detection of the more important quantitative trait loci (QTLs) while minimizing false positives. Type I (false-positive) and Type II (false-negative) error rates were estimated from a computer simulation of QTL mapping in the BXD recombinant inbred (RI) set compromising 26 strains of mice, and comparisons made with theoretical predictions. The results are generally applicable to other RI sets when corrections are made for differing strain numbers and marker densities. Regardless of the number or magnitude of simulated QTLs contributing to the trait variance, the p value necessary to provide adequate protection against both Type I (alpha=.0001) and Type II (beta=.2) errors, a QTL would have to account for more than half of the between-strain (genetic) variance if the BXD or similar set was used alone. In contrast, a two-step mapping strategy was also considered, where RI strains are used as a preliminary screen for QTLs to be specifically tested (confirmed) in an F2 (or other) population. In this case, QTLs accounting for approximately 16% of the between-strain variance could be detected with an 80% probability in the BXD set when alpha = 0.2. To balance the competing goals of minimizing Type I and II errors, an economical strategy is to adopt a more stringent alpha initially for the RI screen, since this requires only a limited genome search in the F2 of the RI-implicated regions (approximately 10% of the F2 genome when p < .01 in the RIs). If confirmed QTLs do not account in the aggregate for a sufficient proportion of the genetic variance, then a more relaxed alpha value can be used in the RI screen to increase the statistical power. This flexibility in setting RI alpha values is appropriate only when adequate protection against Type I errors comes from the F2 (or other) confirmation test(s).
journal_name
Behav Genetjournal_title
Behavior geneticsauthors
Belknap JK,Mitchell SR,O'Toole LA,Helms ML,Crabbe JCdoi
10.1007/BF02359892subject
Has Abstractpub_date
1996-03-01 00:00:00pages
149-60issue
2eissn
0001-8244issn
1573-3297journal_volume
26pub_type
杂志文章abstract::Reading difficulties are both heritable and stable; however, little is known about the etiology of this stability. Results from a preliminary analysis of data from 56 twin pairs who participated in the Colorado Longitudinal Twin Study of Reading Disability (Astrom et al., Twin Res Hum Genet 10:434-439, 2007) suggested...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-011-9445-6
更新日期:2011-09-01 00:00:00
abstract::Five species of whale with matrilineal social systems (daughters remain with mothers) have remarkably low levels of mitochondrial DNA diversity. Non-heritable matriline-level demography could reduce genetic diversity but the required conditions are not consistent with the natural histories of the matrilineal whales. T...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-017-9840-8
更新日期:2017-05-01 00:00:00
abstract::Selection for geotaxis was carried out with flies from a natural population of Drosophila melanogaster; geotactic behavior was measured by means of a Hirsch classification maze. The population was initally almost neutral to gravity, and it responded to both positive (downward) and negative (upward) selection with a re...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01065679
更新日期:1976-01-01 00:00:00
abstract::To study the relationship between genetics and epilepsy, Wistar rats susceptible to audiogenic seizure were selected from the main breeding stock of the Ribeirão Preto School of Medicine at the University of São Paulo, Brazil, and inbred. The criteria for selection were the highest seizure severity index (SI) and shor...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/a:1021099432759
更新日期:2003-01-01 00:00:00
abstract::Results obtained from previous studies of word recognition, reading component skills, and reading composite measures suggest that genetic factors may be more important as a cause for reading disability among children with higher IQ scores than among those with lower IQ scores. To investigate the genetic etiology of re...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/a:1016069012111
更新日期:2002-05-01 00:00:00
abstract::Previously, sequence variation in the glucocorticoid (GR) and mineralocorticoid (MR) receptor genes (NR3C1 and NR3C2, respectively) have been found to be associated with physiological stress responses to social stress tests in small samples of adult men and oral contraceptives (OC) using women. Associations between si...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-010-9385-6
更新日期:2011-03-01 00:00:00
abstract::Courtship song serves as a sexual signal and may contribute to reproductive isolation between closely related species. Using lines of Drosophila pseudoobscura experimentally selected under different sexual selection regimes, we tested whether increased promiscuity and enforced monogamy led to evolutionary changes in c...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-005-3217-0
更新日期:2005-05-01 00:00:00
abstract::The heritability of human personality is well-established. Recent research indicates that nonadditive genetic effects, such as dominance and epistasis, play a large role in personality variation. One possible explanation for the latter finding is that there has been recent selection on human personality. To test this ...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-012-9537-y
更新日期:2012-07-01 00:00:00
abstract::This paper uses data from the National Longitudinal Study of Adolescent Health to examine the extent to which school-level social and institutional factors moderate genetic tendencies to smoke cigarettes. Our analysis relies on a sub-sample of 1,198 sibling and twin pairs nested within 84 schools. We develop a multile...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-008-9197-0
更新日期:2008-05-01 00:00:00
abstract::Previous studies suggest that brain opioid activity decreases aggression in animal models. The main objective of the current study was to examine the possible genetic relationship between intermale aggression and brain levels of enkephalins, endorphins, and dynorphins in 11 inbred strains of mice. Pursuit, rattling, a...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/a:1025774716976
更新日期:2003-09-01 00:00:00
abstract::The goal of the present study is to examine genetic and environmental influences on maternal and teacher ratings of Attention Problems (AP) in 7-year-old children. Teachers completed the Teacher Report Form (N=2259 pairs), and mothers the Child Behavior Checklist (N=2057 pairs). Higher correlations were found in twins...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-006-9084-5
更新日期:2006-11-01 00:00:00
abstract::Offspring outcomes are a function of maternal genetics operating on the intrauterine and postnatal environment, offspring genetics and environmental factors. Partitioning genetic effects into maternal and offspring components requires genotyped mother-offspring pairs or genotyped individuals with phenotypic informatio...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-018-9944-9
更新日期:2019-05-01 00:00:00
abstract::Genomewide scan, as shown by recently published linkage studies on the behavior of mice or in psychiatry, provides evidence for replicated quantitative trait loci (QTL). Several studies of Alzheimer's disease have demonstrated the promise of moving from clinical diagnoses to biological signs for psychiatric investigat...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/a:1010222328509
更新日期:2001-01-01 00:00:00
abstract::Manipulation of endogenous levels of the GABAergic neurosteroid allopregnanolone alters sensitivity to some effects of ethanol. Chronic ethanol withdrawal decreases activity and expression of 5α-reductase-1, an important enzyme in allopregnanolone biosynthesis encoded by the 5α-reductase-1 gene (Srd5a1). The present s...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-014-9691-5
更新日期:2015-05-01 00:00:00
abstract::In the course of the East Flanders Prospective Twin Survey (EFPTS), handedness was assessed as part of a genealogical study (Meulemans et al., 1995) in 1616 twins (808 twin pairs) aged 6 to 28. Our findings are that, in this large population-based study with known placentation and zygosity, the often observed higher f...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF02359484
更新日期:1996-07-01 00:00:00
abstract::We present a repeated-measures, genetic analysis of ethanol-induced anesthesia (sleep time) in mice from the inbred long-sleep (ILS) and short-sleep (ISS) strains of mice and their derived F1 and F2 generations. Mice (total N > 1300) were administered a 4.1 g/kg intraperitoneal dose of ethanol at two times, 7 to 10 da...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF02197243
更新日期:1995-01-01 00:00:00
abstract::Chronic pelvic pain (CPP) is a common condition in women that is difficult to diagnose. Although heritability estimates have been published for some conditions potentially underlying pelvic pain, the heritability of CPP itself has never been investigated. Using data from 623 MZ and 377 DZ female twin pairs aged 29-50 ...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-004-1017-6
更新日期:2005-03-01 00:00:00
abstract::A recent controversy has given reason to examine the place of Burt's data among other behavioral genetic data on IQ. Although Burt's kinship correlations are higher than the average of other studies, his results are generally consistent with other data. ...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01067708
更新日期:1978-01-01 00:00:00
abstract::Roman high- and low-avoidance (RHA/Verh and RLA/Verh) rats are selected and bred for extreme divergence in two-way active avoidance acquisition. In addition, compared to RLA/Verh rats, RHA/Verh rats are (behaviorally and physiologically) less anxious or reactive to stressors, show increased novelty (sensation)-seeking...
journal_title:Behavior genetics
pub_type: 杂志文章,评审
doi:10.1023/a:1021400830503
更新日期:1997-11-01 00:00:00
abstract::Lurcher mutant mice were impaired in spatial orientation and motor coordination in comparison to normal mice. Both groups improved across days in both invisible and visible water maze platform conditions. Contrary to normal mice, lurcher mutants did not improve over days in terms of the time taken to reach a side-bar ...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01071563
更新日期:1994-11-01 00:00:00
abstract::We analyzed the genetic architecture of prepubertal development of relative weight to height in 216 monozygotic and 159 dizygotic complete Japanese twin pairs (52% girls). Ponderal index at birth (kg/m(3)) and body mass index (BMI, kg/m(2)) from 1 to 11 years of age were used. Additive genetic factors explained the ma...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-010-9380-y
更新日期:2011-03-01 00:00:00
abstract::The attempt to characterize high- and low-selected lines on new variables poses serious interpretative problems when replicate lines are not available. Modest but significant line differences on new measures may be due to genetic drift totally irrelevant to the originally selected trait. Often these differences are ex...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01066250
更新日期:1989-07-01 00:00:00
abstract::The role of non-shared environment (NSE) in the development of psychological traits is usually comparable with that of the genotype. However, no specific factors of NSE with significant impact on such traits have been discovered so far. We propose that the current failures in understanding the origin of NSE are at lea...
journal_title:Behavior genetics
pub_type: 杂志文章,评审
doi:10.1007/s10519-019-09950-1
更新日期:2019-05-01 00:00:00
abstract::Fingerprints and handedness were measured in 2169 subjects. Left-handers were more likely to have an increased number of arches and radial loops, while having fewer whorls and lower pattern intensity than right-handers. Analyzing by hand and digit, the differences were most marked on the left hand, which showed signif...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01067817
更新日期:1994-03-01 00:00:00
abstract::Components of the communication system between infant and adult rodents based on ultrasonic vocalizations (USVs) of infants are analyzed. USVs are most often emitted from a pup lost outside the nest in response to changes of: (i) body temperature, (ii) contact with adults/littermates, (iii) handling, and (iv) smell. T...
journal_title:Behavior genetics
pub_type: 杂志文章,评审
doi:10.1007/s10519-004-0853-8
更新日期:2005-01-01 00:00:00
abstract::Age-related changes are analyzed in the correlation of 3416 monozygotic and 3780 dizygotic U.S. twin pairs aged between 9 and 75+ years for conservatism scores derived from a 28-item social attitude inventory. The effects of the shared environment are overwhelming in twins aged 20 years or younger. In older twins, gen...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/a:1025633307992
更新日期:1997-03-01 00:00:00
abstract::The non-synonymous SNP rs2228145 in the IL6R gene on chromosome 1q21.3 is associated with a wide range of common diseases, including asthma, rheumatoid arthritis, type 1 diabetes and coronary heart disease. We examined the contribution of this functional IL6R gene polymorphism rs2228145 versus other genome-wide SNPs t...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-014-9656-8
更新日期:2014-07-01 00:00:00
abstract::Differences between population-typical norms of individual variability were studied in five genetic lines of Japanese quail (Coturnix coturnix japonica); two (BL and RL) were bidirectionally selected for early approach preference between blue and red stimuli, two (Hi and Lo) for high and low imprintabilities to the sa...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01074309
更新日期:1992-09-01 00:00:00
abstract::Callous-unemotional (CU) traits comprise the core symptoms of psychopathy, yet no study has estimated the heritability of CU traits in a community sample of children using an instrument designed solely to assess CU traits. The current study uses data from 339 twin pairs aged 9-14 to examine the reliability and heritab...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-016-9831-1
更新日期:2017-03-01 00:00:00
abstract::Genetic strains of mice represent an important resource for research on the biological determinants of complex diseases and behavioral phenotypes. To date, the approaches used have had little success in identifying causal genes. We have evaluated brain gene expression in C57BL/6J (B6) and DBA/2J (D2) inbred mouse stra...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/B:BEGE.0000023648.78190.ee
更新日期:2004-07-01 00:00:00