Calculating Power to Detect Maternal and Offspring Genetic Effects in Genetic Association Studies.

Abstract:

:Offspring outcomes are a function of maternal genetics operating on the intrauterine and postnatal environment, offspring genetics and environmental factors. Partitioning genetic effects into maternal and offspring components requires genotyped mother-offspring pairs or genotyped individuals with phenotypic information on themselves and their offspring. We performed asymptotic power calculations and data simulations to estimate power to detect maternal and offspring genetic effects under a range of different study designs and models. We also developed the "Maternal and offspring Genetic effects Power Calculator" (M-GPC), an online utility which allows users to estimate the power to detect maternal and offspring genetic effects in their own studies. We find that approximately 50,000 genotyped mother-offspring pairs will be required to detect realistically sized maternal or offspring genetic effects (> 0.1% variance explained) with appreciable power (power > 90%, α = 5 × 10-8, two degree of freedom test), whereas greater than 10,000 pairs will be required to determine whether known genetic loci have maternal and/or offspring genetic effects (power > 78%, α = 0.05). The structural equation modelling framework espoused in this manuscript provides a natural method of combining different data structures including those present in large scale biobanks in order to maximize power to detect maternal and offspring genetic effects. We conclude that the sample sizes required to detect maternal or offspring genetic effects that explain realistic proportions of the trait variance with appreciable power are achievable and within the range of current research consortia.

journal_name

Behav Genet

journal_title

Behavior genetics

authors

Moen GH,Hemani G,Warrington NM,Evans DM

doi

10.1007/s10519-018-9944-9

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

327-339

issue

3

eissn

0001-8244

issn

1573-3297

pii

10.1007/s10519-018-9944-9

journal_volume

49

pub_type

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