Quantitative trait locus mapping: fishing strategy or replicable results?

Abstract:

:Genomewide scan, as shown by recently published linkage studies on the behavior of mice or in psychiatry, provides evidence for replicated quantitative trait loci (QTL). Several studies of Alzheimer's disease have demonstrated the promise of moving from clinical diagnoses to biological signs for psychiatric investigations. Empirical studies also demonstrate that genetic background, differences in environment, epistatic effects, and definition of the phenotype (including psychiatric diagnosis) all actively contribute to limit the duplication of QTL.

journal_name

Behav Genet

journal_title

Behavior genetics

authors

Roubertoux PL,Le Roy-Duflos I

doi

10.1023/a:1010222328509

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

141-8

issue

1

eissn

0001-8244

issn

1573-3297

journal_volume

31

pub_type

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