Abstract:
:Gender-moderated gene-environment interactions are rarely explored, raising concerns about inaccurate specification of etiological models and inferential errors. The current study examined the influence of gender, negative and positive daily life events, and GABRA2 genotype (SNP rs279871) on alcohol dependence, testing two- and three-way interactions between these variables using multi-level regression models fit to data from 2,281 White participants in the Collaborative Study on the Genetics of Alcoholism. Significant direct effects of variables of interest were identified, as well as gender-specific moderation of genetic risk on this SNP by social experiences. Higher levels of positive life events were protective for men with the high-risk genotype, but not among men with the low-risk genotype or women, regardless of genotype. Our findings support the disinhibition theory of alcohol dependence, suggesting that gender differences in social norms, constraints and opportunities, and behavioral undercontrol may explain men and women's distinct patterns of association.
journal_name
Behav Genetjournal_title
Behavior geneticsauthors
Perry BL,Pescosolido BA,Bucholz K,Edenberg H,Kramer J,Kuperman S,Schuckit MA,Nurnberger JI Jrdoi
10.1007/s10519-013-9607-9subject
Has Abstractpub_date
2013-09-01 00:00:00pages
402-14issue
5eissn
0001-8244issn
1573-3297journal_volume
43pub_type
杂志文章abstract::This is the first report of data analyses from a consortium of longitudinal genetic-risk studies on offspring of schizophrenic parents (CLOSSER) who were followed from birth or mid-childhood to their early 20's or considerably older ages. Three of the CLOSSER studies provide data to enable us to address long-persistin...
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pub_type: 杂志文章,评审
doi:10.1007/s10519-005-3227-y
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journal_title:Behavior genetics
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journal_title:Behavior genetics
pub_type: 杂志文章
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doi:10.1007/s10519-010-9385-6
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journal_title:Behavior genetics
pub_type: 杂志文章
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journal_title:Behavior genetics
pub_type: 杂志文章,评审
doi:10.1007/s10519-004-0853-8
更新日期:2005-01-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-005-9022-y
更新日期:2006-03-01 00:00:00
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journal_title:Behavior genetics
pub_type: 评论,杂志文章
doi:10.1007/BF01067000
更新日期:1992-03-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-005-2791-5
更新日期:2005-07-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章,评审
doi:10.1007/BF01066634
更新日期:1992-11-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-010-9387-4
更新日期:2011-03-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/a:1025601828464
更新日期:1997-05-01 00:00:00
abstract::In the original version of this article, unfortunately, in the acknowledgement section "National Institutes of Health (NIH, R37 AG033590-08) to J Cacioppo" was omitted. This has been corrected by publishing this erratum. ...
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pub_type: 已发布勘误
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pub_type: 杂志文章
doi:10.1007/s10519-014-9676-4
更新日期:2015-01-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/a:1025369525924
更新日期:2003-07-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01066177
更新日期:1975-07-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章,评审
doi:10.1023/a:1021400830503
更新日期:1997-11-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Behavior genetics
pub_type: 杂志文章
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更新日期:2007-03-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF02359756
更新日期:1996-09-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-015-9741-7
更新日期:2016-03-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/a:1001963906258
更新日期:2000-05-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/a:1021494023660
更新日期:1999-01-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01066662
更新日期:1992-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
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journal_title:Behavior genetics
pub_type: 杂志文章
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