Abstract:
:In the present study we evaluated long term memory in twenty individuals with molecularly confirmed diagnosis of Noonan syndrome and LEOPARD syndrome, two disorders caused by mutations in genes coding transducers participating in the RAS-MAPK signaling cascade. The profile of explicit long term memory abilities was investigated using PROMEA, which includes a battery of tests specifically developed to assess memory and learning in verbal, visual and spatial domains. Ten individuals (50%) had impaired (≤5th percentile) or below average (≤15th percentile) performance on a delayed verbal free recall memory task, four (20%) on a delayed visual recognition memory task, and only one (5%) on a delayed spatial recognition memory task. Our data suggest that dysregulation of the RAS-MAPK cascade may be associated with a pattern of reduced verbal recall memory performance but relative sparing of visual and spatial recognition memory.
journal_name
Behav Genetjournal_title
Behavior geneticsauthors
Alfieri P,Cesarini L,Mallardi M,Piccini G,Caciolo C,Leoni C,Mirante N,Pantaleoni F,Digilio MC,Gambardella ML,Tartaglia M,Vicari S,Mercuri E,Zampino Gdoi
10.1007/s10519-011-9446-5subject
Has Abstractpub_date
2011-05-01 00:00:00pages
423-9issue
3eissn
0001-8244issn
1573-3297journal_volume
41pub_type
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