Long term memory profile of disorders associated with dysregulation of the RAS-MAPK signaling cascade.

Abstract:

:In the present study we evaluated long term memory in twenty individuals with molecularly confirmed diagnosis of Noonan syndrome and LEOPARD syndrome, two disorders caused by mutations in genes coding transducers participating in the RAS-MAPK signaling cascade. The profile of explicit long term memory abilities was investigated using PROMEA, which includes a battery of tests specifically developed to assess memory and learning in verbal, visual and spatial domains. Ten individuals (50%) had impaired (≤5th percentile) or below average (≤15th percentile) performance on a delayed verbal free recall memory task, four (20%) on a delayed visual recognition memory task, and only one (5%) on a delayed spatial recognition memory task. Our data suggest that dysregulation of the RAS-MAPK cascade may be associated with a pattern of reduced verbal recall memory performance but relative sparing of visual and spatial recognition memory.

journal_name

Behav Genet

journal_title

Behavior genetics

authors

Alfieri P,Cesarini L,Mallardi M,Piccini G,Caciolo C,Leoni C,Mirante N,Pantaleoni F,Digilio MC,Gambardella ML,Tartaglia M,Vicari S,Mercuri E,Zampino G

doi

10.1007/s10519-011-9446-5

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

423-9

issue

3

eissn

0001-8244

issn

1573-3297

journal_volume

41

pub_type

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