The contribution of the functional IL6R polymorphism rs2228145, eQTLs and other genome-wide SNPs to the heritability of plasma sIL-6R levels.

Abstract:

:The non-synonymous SNP rs2228145 in the IL6R gene on chromosome 1q21.3 is associated with a wide range of common diseases, including asthma, rheumatoid arthritis, type 1 diabetes and coronary heart disease. We examined the contribution of this functional IL6R gene polymorphism rs2228145 versus other genome-wide SNPs to the variance of sIL-6R levels in blood plasma in a large population-based sample (N ~5,000), and conducted an expression QTL analysis to identify SNPs associated with IL6R gene expression. Based on data from 2,360 twin families, the broad heritability of sIL-6R was estimated at 72 and 51% of the total variance was explained by the functional SNP rs2228145. Converging findings from GWAS, linkage, and GCTA analyses indicate that additional variance of sIL-6R levels can be explained by other variants in the IL6R region, including variants at the 3'-end of IL6R tagged by rs60760897 that are associated with IL6R RNA expression.

journal_name

Behav Genet

journal_title

Behavior genetics

authors

van Dongen J,Jansen R,Smit D,Hottenga JJ,Mbarek H,Willemsen G,Kluft C,AAGC Collaborators.,Penninx BW,Ferreira MA,Boomsma DI,de Geus EJ

doi

10.1007/s10519-014-9656-8

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

368-82

issue

4

eissn

0001-8244

issn

1573-3297

journal_volume

44

pub_type

杂志文章
  • Influence of early environment on the circadian period of the tau-mutant hamster.

    abstract::The role of the period of the environmental cycle during gestation and infancy on the circadian period of adult hamsters was studied. Tau-mutant hamsters of all three genotypes (+/+, 24-h circadian period; +/tau, 22-h period; tau/tau, 20-h period) were conceived and raised under either a 20-h light-dark cycle or a 24-...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1023/a:1021428209122

    authors: Refinetti R

    更新日期:1998-03-01 00:00:00

  • Natural genetic variation in complex mating behaviors of male Drosophila melanogaster.

    abstract::Mating behavior, including courtship and copulation, is a main component of male fitness, especially in species with no parental care. Variation in this behavior can thus be a target for mate choice and sexual selection, and can lead to evolution. The fruit fly, Drosophila melanogaster, has well-documented complex mal...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-008-9204-5

    authors: Ruedi EA,Hughes KA

    更新日期:2008-07-01 00:00:00

  • Ethanol-induced anesthesia in inbred strains of long-sleep and short-sleep mice: a genetic analysis of repeated measures using censored data.

    abstract::We present a repeated-measures, genetic analysis of ethanol-induced anesthesia (sleep time) in mice from the inbred long-sleep (ILS) and short-sleep (ISS) strains of mice and their derived F1 and F2 generations. Mice (total N > 1300) were administered a 4.1 g/kg intraperitoneal dose of ethanol at two times, 7 to 10 da...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/BF02197243

    authors: Markel PD,DeFries JC,Johnson TE

    更新日期:1995-01-01 00:00:00

  • Resemblances of parents and twins in sports participation and heart rate.

    abstract::A model to analyze resemblances of twins and parents using LISREL is outlined and applied to sports participation and heart-rate data. Sports participation and heart rate were measured in 44 monozygotic and 46 dizygotic adolescent twin pairs and in their parents. Genetic factors influence variation in both sports beha...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/BF01065888

    authors: Boomsma DI,van den Bree MB,Orlebeke JF,Molenaar PC

    更新日期:1989-01-01 00:00:00

  • Body fat in identical twins reared apart: roles for genes and environment.

    abstract::We report analyses of data on body fat from a cohort of 34 separated monozygotic twin pairs (MZA) and a matched sample of 38 pairs of monozygotic twins reared together (MZT) originally studied by James Shields. The correlation for MZA pairs was .61 and the correlation for MZT pairs was .75. These correlations did not ...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/BF01067662

    authors: Price RA,Gottesman II

    更新日期:1991-01-01 00:00:00

  • Genetic variance in a component of the language acquisition device: ROBO1 polymorphisms associated with phonological buffer deficits.

    abstract::The region containing ROBO1 (Chromosome 3p12.3) has been implicated as a susceptibility gene for reading disorder and language deficit by translocation and linkage data. No association studies have yet been reported supporting any candidate gene. Here we report the first association of this gene with language deficits...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-010-9402-9

    authors: Bates TC,Luciano M,Medland SE,Montgomery GW,Wright MJ,Martin NG

    更新日期:2011-01-01 00:00:00

  • Escape efficiency of diploid and polyploid frogs: a comparison of Odontophrynus cultripes (2n = 22) and O. americanus (4n = 44).

    abstract::The escape efficiency of two closely related species of frogs, Odontophrynus cultripes (2n = 22) and the tetraploid O. americanus (4n = 44), were compared in a shuttle box and under simulated naturalistic conditions. O. americanus was generally superior to O. cultripes, and females tended to outperform males within bo...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/BF01065462

    authors: Murphey RM,Beçak W,Dias de Moraes AE

    更新日期:1981-05-01 00:00:00

  • Genetic differences in learning behavior in honeybees (Apis mellifera capensis).

    abstract::Workers from colonies of Cape honeybees show marked phenotypic differences in performance in proboscis extension reflex (PER) conditioning. Analysis of these differences using parthenogenetic offspring groups permitted the estimation of genotypic values and revealed a high degree of genetic variability that is evident...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/BF01065820

    authors: Brandes C

    更新日期:1991-05-01 00:00:00

  • Assortative mating in Drosophila adapted to a microsite ecological gradient.

    abstract::Elucidating the causes of population divergence, and ultimately speciation, is a central objective of evolutionary biology. A number of previous studies of Drosophila populations from the Nahal Oren canyon (Mt Carmel, Israel) revealed significant interslope differences for a complex of fitness and behavioral traits. P...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-005-6119-2

    authors: Singh SR,Rashkovetsky E,Iliadi K,Nevo E,Korol A

    更新日期:2005-11-01 00:00:00

  • Gene×Environment interactions in early externalizing behaviors: parental emotional support and socioeconomic context as moderators of genetic influences?

    abstract::This study uses longitudinal population-based samples of young siblings to examine the effects of two hypothesized moderators of early externalizing behaviors: parental emotional support and family socioeconomic status. The first sample, a twin sample from the Early Childhood Longitudinal Study-Birth Cohort (ECLS-B), ...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-014-9664-8

    authors: Cheung AK,Harden KP,Tucker-Drob EM

    更新日期:2014-09-01 00:00:00

  • A quantitative genetic analysis of locomotor activity in CXB recombinant inbred mice.

    abstract::Recent studies have identified genes that influence the length of the circadian period maintained by mice housed under constant lighting conditions. However, a less studied circadian activity variable is the amplitude of daily oscillations in locomotor activity. This parameter reflects spontaneous activity exhibited u...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1023/a:1021657800287

    authors: Toth LA,Williams RW

    更新日期:1999-09-01 00:00:00

  • Genetic and environmental influences on depressive symptoms in Chinese adolescents.

    abstract::Adolescent depression is common and has become a major public health concern in China, yet little research has examined the etiology of depression in Chinese adolescents. In the present study, genetic and environmental influences on Chinese adolescent depressive symptoms were investigated in 1,181 twin pairs residing ...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-013-9632-8

    authors: Chen J,Li X,Natsuaki MN,Leve LD,Harold GT

    更新日期:2014-01-01 00:00:00

  • Differences between two psychogenetically selected lines of rats in a swimming pool matching-to-place task: long-term effects of infantile stimulation.

    abstract::The present study explored the effects of infantile stimulation (i.e., neonatal handling or NH) on the performance of 18-month-old Roman high-avoidance (RHA/Verh) and low-avoidance (RLA/Verh) rats in a swimming pool matching-to-place (SPMP) test. This test (also called repeated acquisition and place learning-set parad...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1023/a:1015253807488

    authors: Aguilar R,Escorihuela RM,Gil L,Tobeña A,Fernández-Teruel A

    更新日期:2002-03-01 00:00:00

  • Family matters: happiness in nuclear families and twins.

    abstract::Biometric studies have shown that happiness is strongly affected by genes. The findings are mainly based on twin data, however, and the full validity of the results has been debated. To overcome some limitations in classical twin research, we examined aetiological sources of subjective well-being (SWB), using two inde...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-010-9365-x

    authors: Nes RB,Czajkowski N,Tambs K

    更新日期:2010-09-01 00:00:00

  • Cultural Hitchhiking in the Matrilineal Whales.

    abstract::Five species of whale with matrilineal social systems (daughters remain with mothers) have remarkably low levels of mitochondrial DNA diversity. Non-heritable matriline-level demography could reduce genetic diversity but the required conditions are not consistent with the natural histories of the matrilineal whales. T...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-017-9840-8

    authors: Whitehead H,Vachon F,Frasier TR

    更新日期:2017-05-01 00:00:00

  • Estimating the sex-specific effects of genes on facial attractiveness and sexual dimorphism.

    abstract::Human facial attractiveness and facial sexual dimorphism (masculinity-femininity) are important facets of mate choice and are hypothesized to honestly advertise genetic quality. However, it is unclear whether genes influencing facial attractiveness and masculinity-femininity have similar, opposing, or independent effe...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-013-9627-5

    authors: Mitchem DG,Purkey AM,Grebe NM,Carey G,Garver-Apgar CE,Bates TC,Arden R,Hewitt JK,Medland SE,Martin NG,Zietsch BP,Keller MC

    更新日期:2014-05-01 00:00:00

  • Correlated response in selection for aggressiveness in female mice. I. Male aggressiveness.

    abstract::Males from the fifty selected generation of a selection program for aggressiveness in female Mus musculus (Ebert and Hyde, 1976) were tested to determine whether male aggressiveness showed a correlated response in selection for female aggressiveness. The results indicated that male aggression had not shown a correlate...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/BF01065699

    authors: Hyde JS,Ebert PD

    更新日期:1976-10-01 00:00:00

  • A Novel Model to Explain Extreme Feather Pecking Behavior in Laying Hens.

    abstract::Feather pecking (FP) is a serious economic and welfare problem in the domestic fowl. It has recently been shown that the distribution of FP bouts within groups is heterogeneous and contains a sub-population of extreme feather peckers (EFP). The present study proposed a novel model to detect EFP hens. A mixture of two ...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-019-09971-w

    authors: Iffland H,Wellmann R,Preuß S,Tetens J,Bessei W,Piepho HP,Bennewitz J

    更新日期:2020-01-01 00:00:00

  • Tspyl2 Loss-of-Function Causes Neurodevelopmental Brain and Behavior Abnormalities in Mice.

    abstract::Testis specific protein, Y-encoded-like 2 (TSPYL2) regulates the expression of genes encoding glutamate receptors. Glutamate pathology is implicated in neurodevelopmental conditions such as autism spectrum disorder, attention deficit hyperactivity disorder (ADHD) and schizophrenia. In line with this, a microduplicatio...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-015-9777-8

    authors: Li Q,Chan SY,Wong KK,Wei R,Leung YO,Ding AY,Hui TC,Cheung C,Chua SE,Sham PC,Wu EX,McAlonan GM

    更新日期:2016-07-01 00:00:00

  • Individual differences in handedness and specific speech and language impairment: evidence against a genetic link.

    abstract::Data from two twin studies were used to address two related questions. First, is there any association between handedness and specific speech and language impairment (SSLI) in children? Second, is there genetic influence on individual differences in handedness and, if so, are the same genes implicated in the cause of ...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1023/a:1012239617367

    authors: Bishop DV

    更新日期:2001-07-01 00:00:00

  • The Burt controversy: a comparison of Burt's data on IQ with data from other studies.

    abstract::A recent controversy has given reason to examine the place of Burt's data among other behavioral genetic data on IQ. Although Burt's kinship correlations are higher than the average of other studies, his results are generally consistent with other data. ...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/BF01067708

    authors: Rowe D,Plomin R

    更新日期:1978-01-01 00:00:00

  • The Inventory of Callous-Unemotional Traits (ICU) in Children: Reliability and Heritability.

    abstract::Callous-unemotional (CU) traits comprise the core symptoms of psychopathy, yet no study has estimated the heritability of CU traits in a community sample of children using an instrument designed solely to assess CU traits. The current study uses data from 339 twin pairs aged 9-14 to examine the reliability and heritab...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-016-9831-1

    authors: Moore AA,Carney D,Moroney E,Machlin L,Towbin KE,Brotman MA,Pine DS,Leibenluft E,Roberson-Nay R,Hettema JM

    更新日期:2017-03-01 00:00:00

  • Genetic influences on political ideologies: twin analyses of 19 measures of political ideologies from five democracies and genome-wide findings from three populations.

    abstract::Almost 40 years ago, evidence from large studies of adult twins and their relatives suggested that between 30 and 60% of the variance in social and political attitudes could be explained by genetic influences. However, these findings have not been widely accepted or incorporated into the dominant paradigms that explai...

    journal_title:Behavior genetics

    pub_type: 杂志文章,meta分析

    doi:10.1007/s10519-014-9648-8

    authors: Hatemi PK,Medland SE,Klemmensen R,Oskarsson S,Littvay L,Dawes CT,Verhulst B,McDermott R,Nørgaard AS,Klofstad CA,Christensen K,Johannesson M,Magnusson PK,Eaves LJ,Martin NG

    更新日期:2014-05-01 00:00:00

  • Courtship bout duration in per circadian period mutants in Drosophila melanogaster.

    abstract::Mutations on the period locus of Drosophila melanogaster influence circadian periods as well as the rhythm in inter-pulse intervals in male courtship song; perL mutations produce long circadian periods and courtship song rhythms and per(s) mutations produce short circadian periods and courtship song rhythms. Thus, the...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1023/a:1021625819967

    authors: Roche JP,Talyn BC,Dowse HB

    更新日期:1998-09-01 00:00:00

  • Absence of an association between motor coordination and spatial orientation in lurcher mutant mice.

    abstract::Lurcher mutant mice were impaired in spatial orientation and motor coordination in comparison to normal mice. Both groups improved across days in both invisible and visible water maze platform conditions. Contrary to normal mice, lurcher mutants did not improve over days in terms of the time taken to reach a side-bar ...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/BF01071563

    authors: Lalonde R,Thifault S

    更新日期:1994-11-01 00:00:00

  • Congenic mouse strains enable discrimination of genetic determinants contributing to fear and fear memory.

    abstract::The ability to learn and remember is variable within a population of a given species, including humans. This is due in part to genetic variation between individuals. However, only few genes have been identified that contribute to variation in learning and memory. Two inbred mouse strains, C57Bl/6J (B6) and DBA/2J (D2)...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-010-9387-4

    authors: Wilson YM,Brodnicki TC,Lawrence AJ,Murphy M

    更新日期:2011-03-01 00:00:00

  • Generalist genes and high cognitive abilities.

    abstract::The concept of generalist genes operating across diverse domains of cognitive abilities is now widely accepted. Much less is known about the etiology of the high extreme of performance. Is there more specialization at the high extreme? Using a representative sample of 4,000 12-year-old twin pairs from the UK Twins Ear...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-009-9271-2

    authors: Haworth CM,Dale PS,Plomin R

    更新日期:2009-07-01 00:00:00

  • Quantile-Specific Heritability of Intakes of Alcohol but not Other Macronutrients.

    abstract::Genetic heritability (h2) of alcohol use is reported to be greater in rural dwellers, distressed marriages, low socioeconomic status, in girls who are unmarried or lacking closeness with their parents or religious upbringing, in less-educated men, and in adolescents with peers using alcohol. However, these are all ris...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-020-10005-z

    authors: Williams PT

    更新日期:2020-09-01 00:00:00

  • Decomposition of Mean Sex Differences in Alcohol Use Within a Genetic Factor Model.

    abstract::A wealth of literature suggests that normative and heavy alcohol consumption continue to follow a historical pattern of greater prevalence among males as compared to females. Some prior research suggested that sex-specific factors might explain some of this gender gap. Generally speaking, though, more recent studies h...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-020-10004-0

    authors: Richardson GB,Boutwell BB

    更新日期:2020-09-01 00:00:00

  • Individual differences in puberty onset in girls: Bayesian estimation of heritabilities and genetic correlations.

    abstract::: We report heritabilities for individual differences in female pubertal development at the age of 12. Tanner data on breast and pubic hair development in girls and data on menarche were obtained from a total of 184 pairs of monozygotic and dizygotic twins. Genetic correlations were estimated to determine to what exte...

    journal_title:Behavior genetics

    pub_type: 杂志文章

    doi:10.1007/s10519-005-9022-y

    authors: van den Berg SM,Setiawan A,Bartels M,Polderman TJ,van der Vaart AW,Boomsma DI

    更新日期:2006-03-01 00:00:00