Abstract：
:Previous studies suggest that brain opioid activity decreases aggression in animal models. The main objective of the current study was to examine the possible genetic relationship between intermale aggression and brain levels of enkephalins, endorphins, and dynorphins in 11 inbred strains of mice. Pursuit, rattling, and attack behaviors were observed in a dyadic encounter with a standard opponent. It appeared that, as expected, enkephalins and endorphins were always negatively correlated with aggression scores. The findings indicate that brain Met5-enkephalin levels were significantly and highly positively correlated with attack latency. Brain adrenocorticotrophic hormone (ACTH) and beta-endorphin levels were significantly and negatively correlated with the number of rattlings, which is consistent with the hypothesis that rattling is a stress-related behavior. In contrast with Met5-enkephalin, ACTH and beta-endorphin, the correlations between dynorphin A and aggression scores were nonsignificant and very low. These preliminary results suggest that common genetic sources of variation contribute to differences between the 11 inbred strains in both endogenous opioidergic systems and intermale aggression. Further studies are required to confirm the genetic relationship between offensive aggression and brain enkephalins and endorphins and to better understand the mechanisms underlying the role of endogenous opioids in offensive aggression with regard to opioid receptor activity.
journal_name
Behav Genetjournal_title
Behavior geneticsauthors
Tordjman S,Carlier M,Cohen D,Cesselin F,Bourgoin S,Colas-Linhart N,Petiet A,Perez-Diaz F,Hamon M,Roubertoux PLdoi
10.1023/a:1025774716976subject
Has Abstractpub_date
2003-09-01 00:00:00pages
529-36issue
5eissn
0001-8244issn
1573-3297pii
470345journal_volume
33pub_type
杂志文章abstract：:Workers from colonies of Cape honeybees show marked phenotypic differences in performance in proboscis extension reflex (PER) conditioning. Analysis of these differences using parthenogenetic offspring groups permitted the estimation of genotypic values and revealed a high degree of genetic variability that is evident...
journal_title：Behavior genetics
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doi：10.1007/BF01065820
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journal_title：Behavior genetics
pub_type： 杂志文章
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journal_title：Behavior genetics
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pub_type： 杂志文章
doi：10.1007/s10519-005-9022-y
更新日期：2006-03-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01070741
更新日期：1990-01-01 00:00:00
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更新日期：2011-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s10519-005-3217-0
更新日期：2005-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/BF02359756
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doi：10.1007/s10519-006-9065-8
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journal_title：Behavior genetics
pub_type： 杂志文章,评审
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journal_title：Behavior genetics
pub_type： 杂志文章
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更新日期：1991-01-01 00:00:00
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doi：10.1007/s10519-007-9170-3
更新日期：2008-01-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
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更新日期：1995-07-01 00:00:00
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journal_title：Behavior genetics
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doi：10.1023/a:1023450625826
更新日期：2003-05-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01070002
更新日期：1981-09-01 00:00:00
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journal_title：Behavior genetics
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