The G619A Aa-nat gene polymorphism does not contribute to sleep time variation in the Brazilian population.

Abstract:

:Genes involved in melatonin synthesis, such as Aa-nat, may be important for our understanding of diurnal preference and circadian rhythm disturbances in humans. In Japan, Hohjoh et al. reported increased allelic frequencies of the 619A allele of the G619A Aa-nat gene polymorphism in a sample of Delayed Sleep Phase Syndrome (DSPS) patients. The present study sought to analyze G619A polymorphism frequency in a Brazilian sample, including DSPS patients. We found almost no allelic variation for G619A polymorphism in our sample, except for two heterozygous samples out of 551. Our results leave open the question of whether there would be an association if there were some genetic variation in our population. It is important to analyze different ethnic groups in order to validate the effect of G619A polymorphism on sleep timing.

journal_name

Behav Genet

journal_title

Behavior genetics

authors

Pereira DS,Pedrazzoli M,Koike Bdel V,Louzada FM,Benedito-Silva AA,Lopez AR,Tufik S

doi

10.1007/s10519-007-9155-2

subject

Has Abstract

pub_date

2007-07-01 00:00:00

pages

637-8

issue

4

eissn

0001-8244

issn

1573-3297

journal_volume

37

pub_type

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