Abstract:
:Previous studies have shown associations between single nucleotide polymorphisms (SNPs) in gamma aminobutyric acid receptor alpha 2 (GABRA2) and adolescent conduct disorder (CD) and alcohol dependence in adulthood, but not adolescent alcohol dependence. The present study was intended as a replication and extension of this work, focusing on adolescent CD, adolescent alcohol abuse and dependence (AAD), and adult AAD. Family based association tests were run using Hispanics and non-Hispanic European American subjects from two independent longitudinal samples. Although the analysis provided nominal support for an association with rs9291283 and AAD in adulthood and CD in adolescence, the current study failed to replicate previous associations between two well replicated GABRA2 SNPs and CD and alcohol dependence. Overall, these results emphasize the utility of including an independent replication sample in the study design, so that the results from an individual sample can be weighted in the context of its reproducibility.
journal_name
Behav Genetjournal_title
Behavior geneticsauthors
Melroy WE,Stephens SH,Sakai JT,Kamens HM,McQueen MB,Corley RP,Stallings MC,Hopfer CJ,Krauter KS,Brown SA,Hewitt JK,Ehringer MAdoi
10.1007/s10519-014-9653-ysubject
Has Abstractpub_date
2014-07-01 00:00:00pages
356-67issue
4eissn
0001-8244issn
1573-3297journal_volume
44pub_type
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