Abstract：
:For many psychiatric conditions it is speculated that, rather than being single disease entities, they are a set of several disorders sharing clinical features but having (partly) different underlying causes. The possibility of measuring genetic variation on a large scale has given researchers new hope of identifying these disease subtypes that may differ with respect to prognosis, course, and response to treatment. However, although a considerable number of articles have been published suggesting that we may even be on the verge of making genotype-based diagnoses, the reality is that we do not have a good answer to even the most basic question of how measured genes could best be used to refine diagnostic categories. In this article, we show that for common psychiatric disorders, it may not be possible to simply look for similar genetic profiles in groups of patients. Instead, we propose a model assuming that genotypes affect phenotypes through more or less coherent etiological systems or pathogenic processes and argue that these etiological systems may provide a more fruitful basis for defining disease subtypes. Several examples from the literature that support the face validity of different aspects of our model are given. Finally, we argue that, given our limited knowledge of disease etiology, the use of discovery-oriented techniques requiring extensive data collection and (artificial) intelligent computer searches may be imperative, and discuss the prospect of model-based diagnosis to classify etiologically different disease subtypes.
journal_name
Behav Genetjournal_title
Behavior geneticsauthors
van den Oord E,McClay J,York T,Murrelle L,Robles Jdoi
10.1007/s10519-006-9135-ysubject
Has Abstractpub_date
2007-05-01 00:00:00pages
535-45issue
3eissn
0001-8244issn
1573-3297journal_volume
37pub_type
杂志文章abstract：:A study was conducted to identify quantitative trait loci (QTLs) that affect learning in honeybees. Two F1 supersister queens were produced from a cross between two established lines that had been selected for differences in the speed at which they reverse a learned discrimination between odors. Different families of ...
journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/a:1012227308783
更新日期：2001-05-01 00:00:00
abstract：:Complex illnesses, like depression, are thought to arise from the interplay between psychosocial stressors and genetic predispositions. Approaches that take into account both personal and neighborhood factors and that consider gene regions as well as individual SNPs may be necessary to capture these interactions acros...
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journal_title：Behavior genetics
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-016-9831-1
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01065974
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journal_title：Behavior genetics
pub_type： 杂志文章
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/a:1010222328509
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01065462
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01067533
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journal_title：Behavior genetics
pub_type： 杂志文章
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01066662
更新日期：1992-05-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01066617
更新日期：1992-07-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01066331
更新日期：1991-03-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1023/a:1021631122461
更新日期：1999-11-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-014-9666-6
更新日期：2014-09-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01065901
更新日期：1989-03-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01067986
更新日期：1993-09-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-015-9710-1
更新日期：2015-07-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-011-9445-6
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01067187
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1023/a:1025774716976
更新日期：2003-09-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01065562
更新日期：1990-05-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-016-9792-4
更新日期：2016-09-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-006-9065-8
更新日期：2006-09-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-014-9664-8
更新日期：2014-09-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/BF01065597
更新日期：1980-07-01 00:00:00
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journal_title：Behavior genetics
pub_type： 杂志文章
doi：10.1007/s10519-010-9385-6
更新日期：2011-03-01 00:00:00
