Abstract:
:A central issue in psychiatric genetics is whether positive findings replicate. Zubenko et al. (2002b, Mol. Psychiatry 7:460-467) reported an association of the 124-bp allele of D2S2944 with recurrent early-onset major depression for females. We tested for association of this allele to continuous measures of anxiety, depression and neuroticism in a Dutch sample of 347 males and 448 females, and to DSM-IV major depression in a subsample of 210 males and 295 females. The association of the 124-bp allele to depression in females was not replicated, but there were significant associations (not significant after correction for multiple testing) with anxiety and anxious depression in males. However, the association occurred in the absence of evidence for linkage in this region on chromosome 2.
journal_name
Behav Genetjournal_title
Behavior geneticsauthors
Beem AL,Geus EJ,Hottenga JJ,Sullivan PF,Willemsen G,Slagboom PE,Boomsma DIdoi
10.1007/s10519-005-9006-ysubject
Has Abstractpub_date
2006-01-01 00:00:00pages
127-36issue
1eissn
0001-8244issn
1573-3297journal_volume
36pub_type
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pub_type: 杂志文章
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pub_type: 杂志文章,meta分析
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