Abstract:
:Here we provide a detailed description of the genome-wide information available on the National Longitudinal Study of Adolescent to Adult Health (Add Health) sibling pair subsample (Harris et al. in Twin Res Hum Genet 16:391-398, 2013). A total of 2,020 samples were genotyped (including duplicates) arising from 1946 Add Health individuals from the sibling pairs subsample. After various steps for quality control (QC) and quality assurance (QA), we have high quality genome-wide data available on 1,888 individuals. In this report, we first highlight the QC and QA steps that were taken to prune the data of poorly performing samples and genetic markers. We further estimate the pairwise biological relationships using genome-wide data and compare those estimates to the assumed relationships in Add Health. Additionally, using genome-wide data from known regional reference populations from Europe, West Africa, North and South America, Japan and China, we estimate the relative genetic ancestry of the respondents. Finally, rather than conducting a traditional cross-sectional genome-wide association study (GWAS) of body mass index (BMI), we opted to utilize the extensive publicly available genome-wide information to conduct a weighted GWAS of longitudinal BMI while accounting for both family and ethnic variation.
journal_name
Behav Genetjournal_title
Behavior geneticsauthors
McQueen MB,Boardman JD,Domingue BW,Smolen A,Tabor J,Killeya-Jones L,Halpern CT,Whitsel EA,Harris KMdoi
10.1007/s10519-014-9692-4subject
Has Abstractpub_date
2015-01-01 00:00:00pages
12-23issue
1eissn
0001-8244issn
1573-3297journal_volume
45pub_type
杂志文章abstract::The heritability of human personality is well-established. Recent research indicates that nonadditive genetic effects, such as dominance and epistasis, play a large role in personality variation. One possible explanation for the latter finding is that there has been recent selection on human personality. To test this ...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-012-9537-y
更新日期:2012-07-01 00:00:00
abstract::As a result of different feeding regimens, two laboratory populations of the beetle Callosobruchus maculatus Fab. developed different rates of oviposition. The behavior of the F1 hybrids cannot be explained with an additive model of inheritance. The unusual pattern of inheritance suggests a sex-related factor(s) and a...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01065625
更新日期:1981-03-01 00:00:00
abstract::Previous studies have shown associations between single nucleotide polymorphisms (SNPs) in gamma aminobutyric acid receptor alpha 2 (GABRA2) and adolescent conduct disorder (CD) and alcohol dependence in adulthood, but not adolescent alcohol dependence. The present study was intended as a replication and extension of ...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-014-9653-y
更新日期:2014-07-01 00:00:00
abstract::Chronic pelvic pain (CPP) is a common condition in women that is difficult to diagnose. Although heritability estimates have been published for some conditions potentially underlying pelvic pain, the heritability of CPP itself has never been investigated. Using data from 623 MZ and 377 DZ female twin pairs aged 29-50 ...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-004-1017-6
更新日期:2005-03-01 00:00:00
abstract::Selection for high and low locomotor activity has been applied in two base populations of Drosophila melanogaster of distinct geographical origin. From each base population a high and a low line were selected, in which anesthesia was performed with ether. In addition, from one of the base populations a high line and a...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01067350
更新日期:1979-11-01 00:00:00
abstract::Feather pecking (FP) is a serious economic and welfare problem in the domestic fowl. It has recently been shown that the distribution of FP bouts within groups is heterogeneous and contains a sub-population of extreme feather peckers (EFP). The present study proposed a novel model to detect EFP hens. A mixture of two ...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-019-09971-w
更新日期:2020-01-01 00:00:00
abstract::This article reports the results of 11 generations of selective breeding for isolation-induced, interfemale aggression in Mus musculus. Within-family selection was used to form two high, two low, and two unselected control lines, beginning with a population of wild-trapped mice. Selection was successful in establishin...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01065597
更新日期:1980-07-01 00:00:00
abstract::Sixty-six mice of 11 genetic stocks (the Bailey recombinant inbred strains CXBD, CXBE, CXBG, CXBH, CXBI, CXBJ, CXBK; their progenitor strains, BALB/cBy and C57BL/6By: and the reciprocal hybrids, B6CF and CB6F) were tested in a two-compartment apparatus and in a shuttlebox, with five measures taken relating to activity...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01066277
更新日期:1977-05-01 00:00:00
abstract::Anxiety disorders are phenotypically complex and may involve multiple genetic influences on many neurotransmitter systems. Rodent tests used to investigate genetic influences on anxiety-like phenotypes have face and predictive validity as models for anxiety in humans. If multiple genes contribute additively to a trait...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/B:BEGE.0000009479.02183.1f
更新日期:2004-01-01 00:00:00
abstract::To study the relationship between genetics and epilepsy, Wistar rats susceptible to audiogenic seizure were selected from the main breeding stock of the Ribeirão Preto School of Medicine at the University of São Paulo, Brazil, and inbred. The criteria for selection were the highest seizure severity index (SI) and shor...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/a:1021099432759
更新日期:2003-01-01 00:00:00
abstract::A model to analyze resemblances of twins and parents using LISREL is outlined and applied to sports participation and heart-rate data. Sports participation and heart rate were measured in 44 monozygotic and 46 dizygotic adolescent twin pairs and in their parents. Genetic factors influence variation in both sports beha...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01065888
更新日期:1989-01-01 00:00:00
abstract::Twin studies are useful for assessing the relative importance of genetic or heritable component from the environmental component. In this paper we develop a methodology to study the heritability of age-at-onset or lifespan traits, with application to analysis of twin survival data. Due to limited period of observation...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-007-9150-7
更新日期:2007-07-01 00:00:00
abstract::Artificial selection was used to establish different levels of agonistic behavior in laboratory-reared wild female Mus musculus. A within-family selection design with replicated high and low lines and two nonselected control lines was employed. Females only were tested at 8 weeks of age on 2 consecutive days. Testing ...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01065725
更新日期:1976-07-01 00:00:00
abstract::The concept of generalist genes operating across diverse domains of cognitive abilities is now widely accepted. Much less is known about the etiology of the high extreme of performance. Is there more specialization at the high extreme? Using a representative sample of 4,000 12-year-old twin pairs from the UK Twins Ear...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-009-9271-2
更新日期:2009-07-01 00:00:00
abstract::Parameters of quantitative genetic models have traditionally been estimated by either algebraic manipulation of familial correlations (or familial mean squares), biometric model fitting, or multiple-group covariance structure analysis. With few exceptions, researchers who have used these methods for the analysis of tw...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01066662
更新日期:1992-05-01 00:00:00
abstract::Results obtained from previous studies of word recognition, reading component skills, and reading composite measures suggest that genetic factors may be more important as a cause for reading disability among children with higher IQ scores than among those with lower IQ scores. To investigate the genetic etiology of re...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/a:1016069012111
更新日期:2002-05-01 00:00:00
abstract::Human facial attractiveness and facial sexual dimorphism (masculinity-femininity) are important facets of mate choice and are hypothesized to honestly advertise genetic quality. However, it is unclear whether genes influencing facial attractiveness and masculinity-femininity have similar, opposing, or independent effe...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-013-9627-5
更新日期:2014-05-01 00:00:00
abstract::Effective mapping strategies for quantitative trains must allow for the detection of the more important quantitative trait loci (QTLs) while minimizing false positives. Type I (false-positive) and Type II (false-negative) error rates were estimated from a computer simulation of QTL mapping in the BXD recombinant inbre...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF02359892
更新日期:1996-03-01 00:00:00
abstract::A model based on the latent class model is developed for the effects of genes and environment on multivariate categorical data in twins. The model captures many essential features of dimensional and categorical conceptions of complex behavioral phenotypes and can include, as special cases, a variety of major locus mod...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF01067550
更新日期:1993-01-01 00:00:00
abstract::This is the first report of data analyses from a consortium of longitudinal genetic-risk studies on offspring of schizophrenic parents (CLOSSER) who were followed from birth or mid-childhood to their early 20's or considerably older ages. Three of the CLOSSER studies provide data to enable us to address long-persistin...
journal_title:Behavior genetics
pub_type: 杂志文章,评审
doi:10.1007/s10519-005-3227-y
更新日期:2005-05-01 00:00:00
abstract::Heritability estimates of birth weight have been inconsistent. Possible explanations are heritability changes during gestational age or the influence of covariates (e.g. chorionicity). The aim of this study was to model birth weights of twins across gestational age and to quantify the genetic and environmental compone...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-007-9170-3
更新日期:2008-01-01 00:00:00
abstract::Genetic strains of mice represent an important resource for research on the biological determinants of complex diseases and behavioral phenotypes. To date, the approaches used have had little success in identifying causal genes. We have evaluated brain gene expression in C57BL/6J (B6) and DBA/2J (D2) inbred mouse stra...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/B:BEGE.0000023648.78190.ee
更新日期:2004-07-01 00:00:00
abstract::The region containing ROBO1 (Chromosome 3p12.3) has been implicated as a susceptibility gene for reading disorder and language deficit by translocation and linkage data. No association studies have yet been reported supporting any candidate gene. Here we report the first association of this gene with language deficits...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-010-9402-9
更新日期:2011-01-01 00:00:00
abstract::Most research on child behavior incorporates information from different individuals. While agreement between informants is generally only modest, there is little understanding of the processes underlying disagreement. In twin studies, differential agreement among raters for MZ and DZ twins is of particular concern. Th...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF02197280
更新日期:1995-07-01 00:00:00
abstract::The present study explored the effects of infantile stimulation (i.e., neonatal handling or NH) on the performance of 18-month-old Roman high-avoidance (RHA/Verh) and low-avoidance (RLA/Verh) rats in a swimming pool matching-to-place (SPMP) test. This test (also called repeated acquisition and place learning-set parad...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1023/a:1015253807488
更新日期:2002-03-01 00:00:00
abstract::Elucidating the causes of population divergence, and ultimately speciation, is a central objective of evolutionary biology. A number of previous studies of Drosophila populations from the Nahal Oren canyon (Mt Carmel, Israel) revealed significant interslope differences for a complex of fitness and behavioral traits. P...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-005-6119-2
更新日期:2005-11-01 00:00:00
abstract::The most common alternative to a genetic explanation of left-handedness is that sinistrality arises because of birth stress factors. In a sample of 1398 subjects, the association between birth stress and left-handedness was confirmed. More importantly, it was found that left-handed mothers are more likely to have birt...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/BF02327575
更新日期:1995-11-01 00:00:00
abstract::We examined longitudinally collected behavioral reports by teachers on a unique twin sample at the ages of 7, 8, 9, 10, 11, and 12 years. As twin and adoption studies implicate the role of genetic influence on behavioral problems found to be stable in epidemiological samples, the current study employs a developmental ...
journal_title:Behavior genetics
pub_type: 杂志文章
doi:10.1007/s10519-004-1747-5
更新日期:2005-07-01 00:00:00
abstract::A central issue in psychiatric genetics is whether positive findings replicate. Zubenko et al. (2002b, Mol. Psychiatry 7:460-467) reported an association of the 124-bp allele of D2S2944 with recurrent early-onset major depression for females. We tested for association of this allele to continuous measures of anxiety, ...
journal_title:Behavior genetics
pub_type: 杂志文章,多中心研究
doi:10.1007/s10519-005-9006-y
更新日期:2006-01-01 00:00:00
abstract::Substantial progress has been made recently in analyses of longitudinal twin and family data, principally for two reasons. The first is the continuing development of more refined models for describing longitudinal data; the second is the widespread availability of analytic methods (e.g. LISREL) with which to implement...
journal_title:Behavior genetics
pub_type: 评论,杂志文章
doi:10.1007/BF01067000
更新日期:1992-03-01 00:00:00