Abstract:
:The effectiveness of using amphetamine isomer ratios to determine individual compliance with a Dexedrine (dexamphetamine, Celltech, Slough, UK) treatment regimen for the maintenance and detoxification from amphetamine abuse has been audited. The calculation of l/d-amphetamine isomer ratios in urine has been shown previously to provide an accurate method for determining the compliance of subjects prescribed dexamphetamine. This audit was performed on the results obtained subsequent to the analysis of 369 urine specimens collected from 87 subjects (26 female, 61 male), all prescribed dexamphetamine collected from January 1999 to December 2002. The analysis was performed using a chiral derivatizing agent in conjunction with a gas chromatograph fitted with a mass spectrometer. It was found that only 245 specimens (66%) were deemed to be from compliant subjects. Of the remainder, 60 (16%) were collected when subjects were apparently supplementing their dexamphetamine prescription with illicit amphetamine, and 66 (18%) were collected when subjects were apparently using primarily illicit amphetamine. In summary, a sensitive and specific technique has been developed and applied to the analysis of urine specimens obtained from those prescribed dexamphetamine to facilitate the monitoring of their compliance. It is hoped that this technique may continue to be used to audit further the treatment in these individuals in the future to optimize their management.
journal_name
Addict Bioljournal_title
Addiction biologyauthors
George Sdoi
10.1080/13556210310001646411subject
Has Abstractpub_date
2003-12-01 00:00:00pages
439-43issue
4eissn
1355-6215issn
1369-1600pii
ALFHVQVRJM58NY95journal_volume
8pub_type
杂志文章abstract::Alcoholism is a chronic relapsing disorder, and stress is a key precipitant of relapse. The nucleus incertus (NI) is highly responsive to corticotrophin-releasing factor (CRF) and psychological stressors, receives a CRF innervation and expresses CRF1 and CRF2 receptor mRNA. Furthermore, the ascending NI relaxin-3 syst...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12426
更新日期:2017-11-01 00:00:00
abstract::Methamphetamine (METH) is an increasing popular and highly addictive stimulant associated with autonomic nervous system (ANS) dysfunction, cardiovascular pathology and neurotoxicity. Heart rate variability (HRV) has been used to assess autonomic function and predict mortality in cardiac disorders and drug intoxication...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2010.00270.x
更新日期:2012-05-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12702
更新日期:2020-01-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12161
更新日期:2015-07-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12232
更新日期:2016-07-01 00:00:00
abstract::Frustration represents a particular aspect of the addictive process that is related to loss of control when the expected reward is not obtained. We aim to study the consequences of frustrated expected reward on gene expression in the mouse brain. For this purpose, we used an operant model of frustration using palatabl...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12188
更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12595
更新日期:2018-03-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12042
更新日期:2014-01-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2010.00252.x
更新日期:2010-10-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2007.00067.x
更新日期:2007-06-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2012.00495.x
更新日期:2014-05-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2008.00100.x
更新日期:2008-09-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12183
更新日期:2016-01-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12784
更新日期:2019-09-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2010.00288.x
更新日期:2012-01-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12558
更新日期:2018-09-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556219971542
更新日期:1999-07-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章,评审
doi:10.1080/1355621031000069828
更新日期:2003-03-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12480
更新日期:2018-01-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12584
更新日期:2019-03-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12961
更新日期:2020-08-20 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556210500123217
更新日期:2005-06-01 00:00:00
abstract::The Lewis (LEW) and Fischer 344 (F344) inbred rat strains are frequently used to study the role of genetic factors in vulnerability to drug addiction and relapse. Glutamate and γ-amino butyric acid (GABA) transmission are significantly altered after cocaine-induced reinstatement, although whether LEW and F344 rats dif...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2011.00404.x
更新日期:2013-07-01 00:00:00
abstract::Adolescent alcohol use is associated with increased risk for alcohol use disorders later in life; therefore, identifying biomarkers for initiation of heavy alcohol use, such as individual differences in the development of white-matter microstructure, may inform prevention strategies that improve public health. This pr...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12767
更新日期:2020-05-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/1355621021000006035
更新日期:2002-10-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2009.00164.x
更新日期:2009-09-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章,评审
doi:10.1111/adb.12414
更新日期:2017-09-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2000.tb00200.x
更新日期:2000-07-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556210412331292578
更新日期:2004-09-01 00:00:00