Abstract:
:Smoking withdrawal is associated with significant deficits in the ability to initiate and maintain attention for extended periods of time (i.e. sustained attention; SA). However, the effects of smoking abstinence on the temporal dynamics of neurocognition during SA have not been evaluated. Twenty adult smokers underwent functional magnetic resonance imaging scans following smoking as usual and after 24-hours abstinence. During scanning they completed a SA task with two levels of task difficulty, designed to measure both sustained (i.e. over the duration of the task) and transient (i.e. event-related) activation. Smoking abstinence significantly decreased task accuracy regardless of task difficulty. Compared to smoking as usual, abstinence resulted in decreased sustained activation in right inferior and middle frontal gyri but increased transient activation across dispersed cortical areas including precuneus and right superior frontal gyrus. Greater task difficulty was associated with even greater transient activation during abstinence in mostly right hemisphere regions including right inferior frontal gyrus. These findings suggest smoking withdrawal shifts the temporal and spatial dynamics of neurocognition from sustained, right prefrontal activation reflecting proactive cognitive control (Braver, Gray & Burgess 2009) to more dispersed and transient activation reflecting reactive control.
journal_name
Addict Bioljournal_title
Addiction biologyauthors
Kozink RV,Lutz AM,Rose JE,Froeliger B,McClernon FJdoi
10.1111/j.1369-1600.2010.00252.xsubject
Has Abstractpub_date
2010-10-01 00:00:00pages
480-90issue
4eissn
1355-6215issn
1369-1600journal_volume
15pub_type
杂志文章abstract::Chronic morphine treatment of rats for 2 and 4 weeks led to an increase in morphine-binding cells in the spleen, despite the general reduction of mononuclear cell content in the spleen and thymus. Simultaneously, serum antibodies to morphine (AbM) in haemagglutination titres 1:20 and higher appeared in 50% and 80% of ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/1355621961000125046
更新日期:1996-01-01 00:00:00
abstract::Recent preclinical evidence indicates that the neuropeptide oxytocin may have potential in the treatment of drug dependence and drug withdrawal. Oxytocin reduces methamphetamine self-administration, conditioned place preference and hyperactivity in rodents. However, it is unclear how oxytocin acts in the brain to prod...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2010.00247.x
更新日期:2010-10-01 00:00:00
abstract::We demonstrated that the genotype of the variable number tandem repeats (VNTRs) in the linked polymorphic region (LPR) of the 5' promoter and in the intron 2 (Stin2) transcriptional regulatory domains of the serotonin transporter SLC6A4 gene determined its promoter interactions with transcription factors and co-activa...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2010.00288.x
更新日期:2012-01-01 00:00:00
abstract::The purpose of this study was to explore the effects of cannabidiol (CBD) on binge drinking and evaluate potential gender-related differences. To this aim, male and female C57BL/6J mice (n = 60 per sex) were exposed to the drinking in the dark (DID) model for 4 weeks (DID-1 to DID-4). Dose-response effects of CBD on t...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12765
更新日期:2020-05-01 00:00:00
abstract::Activation of brain microglial cells, microgliosis, has been linked to methamphetamine (MA)-seeking behavior, suggesting that microglia could be a new therapeutic target for MA use disorder. Animal data show marked brain microglial activation following acute high-dose MA, but microglial status in human MA users is unc...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12876
更新日期:2021-01-01 00:00:00
abstract::Methamphetamine (METH) is a highly potent and addictive psychostimulant that is frequently abused worldwide. Although the biggest challenge to the efficient treatment of drug dependence is relapse, its mechanism is completely unclear. Plenty of evidence suggests that inflammation contributes to drug-induced reward esp...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12740
更新日期:2020-03-01 00:00:00
abstract::Drugs of abuse induce widespread synaptic adaptations in the mesolimbic dopamine (DA) neurons. Such drug-induced neuroadaptations may constitute an initial cellular mechanism eventually leading to compulsive drug-seeking behavior. To evaluate the impact of GABAB receptors on addiction-related persistent neuroplasticit...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12688
更新日期:2019-11-01 00:00:00
abstract::Reduced executive control is one of the central components of model on the development and maintenance of Internet gaming disorder (IGD). Among the various executive control problems, high impulsivity has consistently been associated with IGD. We performed voxel-based morphometric analysis with diffeomorphic anatomica...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12552
更新日期:2018-09-01 00:00:00
abstract::Phosphatidylethanol (PEth), a direct ethanol metabolite, is detectable in blood for more than 2 weeks after sustained ethanol intake. Our aim was to assess the usefulness of PEth [comparing sensitivity, specificity and the area under the curve (AUC)] as compared with carbohydrate-deficient transferrin (CDT), gamma-glu...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2006.00040.x
更新日期:2007-03-01 00:00:00
abstract::Little is known about the neural functioning that underpins drug valuation and choice in addiction, including nicotine dependence. Following ad libitum smoking, 19 dependent smokers (smoked≥10/day) and 19 occasional smokers (smoked 0.5-5/week) completed a decision-making task. First, participants stated how much they ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12802
更新日期:2020-07-01 00:00:00
abstract::Behavioral sensitization to cocaine is associated to neuroadaptations that contribute to addiction. Enkephalin is highly expressed in mesocorticolimbic areas associated with cocaine-induced sensitization; however, their influence on cocaine-dependent behavioral and neuronal plasticity has not been explained. In this s...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12200
更新日期:2016-03-01 00:00:00
abstract::Neuroadaptations in the ventral striatum (VS) and ventral midbrain (VMB) following chronic opioid administration are thought to contribute to the pathogenesis and persistence of opiate addiction. In order to identify candidate genes involved in these neuroadaptations, we utilized a behavior-genetics strategy designed ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2012.00470.x
更新日期:2013-05-01 00:00:00
abstract::In keeping with its ability to control the mesoaccumbens dopamine (DA) pathway, the serotonin2C receptor (5-HT2C R) plays a key role in mediating the behavioral and neurochemical effects of drugs of abuse. Studies assessing the influence of 5-HT2C R agonists on cocaine-induced responses have suggested that 5-HT2C Rs c...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12137
更新日期:2015-05-01 00:00:00
abstract::Quitting smoking is notoriously difficult. Models of nicotine dependence posit that strength of cognitive control contributes to maintaining smoking abstinence during smoking cessation attempts. We examine the role for large-scale functional brain systems associated with cognitive control in smoking lapse using a nove...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.13001
更新日期:2021-01-28 00:00:00
abstract::Abstract Twenty-eight Wistar rats treated orally with 20% ethanol solution, were divided into two groups: adult group (n = 19) and aged group (n = 9) consisting of animals aged 4 and 12 months, respectively, at the beginning of the treatment. Neurons from the basal nucleus region were counted and the percentage of cho...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/135562101200100571
更新日期:2002-01-01 00:00:00
abstract::The present study was undertaken to examine whether genetically predetermined differences in components of the endocannabinoid system were present in the brain of Sardinian alcohol-preferring (sP) and Sardinian alcohol-non-preferring (sNP) rats, a pair of rat lines selectively bred for opposite alcohol preference. The...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2010.00299.x
更新日期:2012-01-01 00:00:00
abstract::Erythroycte delta aminolevulinic acid dehydratase (ALAD) has been suggested as a marker for detecting recent alcohol intake. Unlike other markers, ALAD activity decreases after alcohol intake. Review of the literature suggests that the main interest in this marker is because it increases rapidly after withdrawal. The ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556219772778
更新日期:1997-04-01 00:00:00
abstract::Recreational use of the drug 4-methylmethcathinone (mephedrone; 4-MMC) became increasingly popular in the United Kingdom in recent years, spurred in part by the fact that it was not criminalized until April 2010. Although several fatalities have been associated with consumption of 4-MMC and cautions for recreational u...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12038
更新日期:2013-09-01 00:00:00
abstract::This study evaluated the effects of cannabidiol (CBD) on ethanol reinforcement, motivation and relapse in C57BL/6 J mice. The effects of CBD (60 mg/kg, i.p.) on blood ethanol concentration, hypothermia and handling-induced convulsions associated to acute ethanol administration were evaluated. The two-bottle choice par...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12495
更新日期:2018-01-01 00:00:00
abstract::Hangover refers to the cluster of physiological and behavioral symptoms that occur following the end of a drinking episode. While hangover has been studied after the typical oral consumption of alcohol, the occurrence of hangover following intravenous (IV) alcohol administration in human laboratory studies has not bee...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12469
更新日期:2018-01-01 00:00:00
abstract::We examined whether acute administration of phencyclidine (PCP), an antagonist of the N-methyl-D-aspartate (NMDA) receptor-channel complex, can cause neuronal toxicity that is associated with apoptosis. Three- and 24-month-old rats were placed in locomotor activity chambers. PCP (50 mg/kg) or saline (0.15 M NaCl) were...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556210050003748
更新日期:2000-04-01 00:00:00
abstract::The cannabinoid system appears to play a critical facilitative role in mediating the reinforcing effects of nicotine and relapse to nicotine-seeking behaviour in abstinent subjects based on the actions of cannabinoid (CB) receptor antagonists. However, the effects of CB receptor stimulation on nicotine self-administra...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2011.00314.x
更新日期:2012-01-01 00:00:00
abstract::The Lewis (LEW) and Fischer 344 (F344) inbred rat strains are frequently used to study the role of genetic factors in vulnerability to drug addiction and relapse. Glutamate and γ-amino butyric acid (GABA) transmission are significantly altered after cocaine-induced reinstatement, although whether LEW and F344 rats dif...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2011.00404.x
更新日期:2013-07-01 00:00:00
abstract::The AA (alko, alcohol) and ANA (alko, non-alcohol) rat lines were among the earliest rodent lines produced by bidirectional selection for ethanol preference. The purpose of this review is to highlight the strategies for understanding the neurobiological factors underlying differential alcohol-drinking behavior in thes...
journal_title:Addiction biology
pub_type: 杂志文章,评审
doi:10.1111/j.1369-1600.2006.00037.x
更新日期:2006-09-01 00:00:00
abstract::The supply of substitute opioid medication as a treatment for heroin dependence is now common practice. There is growing international interest in the prescription of injectable diamorphine for subgroups of patients who are unable to stop injecting opiate drugs; in the United Kingdom it is estimated that there are cur...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556210120056553
更新日期:2001-07-01 00:00:00
abstract::Intravenous drug addiction is known to be associated with an inordinate morbidity and mortality. As our previous report had identified an immune phenotype consistent with accelerated ageing, we wished to investigate how much of this change may have been related to chronic viral hepatitis. A total of 12 409 clinical pa...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2008.00123.x
更新日期:2009-04-01 00:00:00
abstract::Cocaine self-administration in rats results in dysfunctional neuroadaptations in the prelimbic (PrL) cortex during early abstinence. Central to these adaptations is decreased phospho-extracellular signal-regulated kinase (p-ERK), which plays a key role in cocaine seeking. Normalizing ERK phosphorylation in the PrL cor...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12504
更新日期:2018-01-01 00:00:00
abstract::Numerous studies have explored the morphological differences of the brain between subjects with alcohol use disorder (AUD) and control subjects, but very few have investigated the impact of the duration of alcohol use disorder (DAD) and current level of alcohol consumption (CAC) within AUD subjects using magnetic reso...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12751
更新日期:2020-03-01 00:00:00
abstract::Exposure to smoking-associated environmental cues during smoke cessation elicits self-reported urge/craving to smoke, which precipitates relapse even after prolonged abstinence. Incubation of cue-induced cigarettes craving during abstinence has been observed in human smokers recently. The present studies assessed cue-...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12480
更新日期:2018-01-01 00:00:00
abstract::Although the involvement of dopamine in gambling disorder (GD) has long been hypothesized, its precise role remains unclear. The action of dopamine in the synapses is regulated by the dopamine transporter (DAT). We hereinafter present significant differences between a sample of 15 treatment-seeking GD subjects and 17 ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12677
更新日期:2019-09-01 00:00:00