Abstract：
:Recreational use of the drug 4-methylmethcathinone (mephedrone; 4-MMC) became increasingly popular in the United Kingdom in recent years, spurred in part by the fact that it was not criminalized until April 2010. Although several fatalities have been associated with consumption of 4-MMC and cautions for recreational users about its addictive potential have appeared on Internet forums, very little information about abuse liability for this drug is available. This study was conducted to determine if 4-MMC serves as a reinforcer in a traditional intravenous self-administration model. Groups of male Wistar and Sprague-Dawley rats were prepared with intravenous catheters and trained to self-administer 4-MMC in 1-hour sessions. Per-infusion doses of 0.5 and 1.0 mg/kg were consistently self-administered, resulting in greater than 80% discrimination for the drug-paired lever and mean intakes of about 2-3 mg/kg/hour. Dose-substitution studies after acquisition demonstrated that the number of responses and/or the total amount of drug self-administered varied as a function of dose. In addition, radiotelemetry devices were used to show that self-administered 4-MMC was capable of increasing locomotor activity (Wistar) and decreasing body temperature (Sprague-Dawley). Pharmacokinetic studies found that the T1/2 of 4-MMC was about 1 hour in vivo in rat plasma and 90 minutes using in vitro liver microsomal assays. This study provides evidence of stimulant-typical abuse liability for 4-MMC in the traditional pre-clinical self-administration model.
journal_name
Addict Bioljournal_title
Addiction biologyauthors
Aarde SM,Angrish D,Barlow DJ,Wright MJ Jr,Vandewater SA,Creehan KM,Houseknecht KL,Dickerson TJ,Taffe MAdoi
10.1111/adb.12038subject
Has Abstractpub_date
2013-09-01 00:00:00pages
786-99issue
5eissn
1355-6215issn
1369-1600journal_volume
18pub_type
杂志文章abstract：:Alcohol dependence (AD) affects individuals from all racial/ethnic groups, and previous research suggests that there is considerable variation in AD risk between and among various ancestrally defined groups in the United States. Although the reasons for these differences are likely due in part to contributions of comp...
journal_title：Addiction biology
pub_type： 杂志文章
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更新日期：2019-01-01 00:00:00
abstract：:Methamphetamine (METH) is an increasing popular and highly addictive stimulant associated with autonomic nervous system (ANS) dysfunction, cardiovascular pathology and neurotoxicity. Heart rate variability (HRV) has been used to assess autonomic function and predict mortality in cardiac disorders and drug intoxication...
journal_title：Addiction biology
pub_type： 杂志文章
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journal_title：Addiction biology
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更新日期：2007-06-01 00:00:00
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journal_title：Addiction biology
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journal_title：Addiction biology
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journal_title：Addiction biology
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2009-04-01 00:00:00
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pub_type： 评论,杂志文章
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journal_title：Addiction biology
pub_type： 临床试验,杂志文章,多中心研究
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pub_type： 杂志文章,评审
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更新日期：2018-09-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
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更新日期：2007-03-01 00:00:00
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更新日期：2020-01-01 00:00:00
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更新日期：2016-05-01 00:00:00
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更新日期：2013-05-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
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更新日期：2016-01-01 00:00:00
