Quantification of breath carbon disulphide and acetone following a single dose of disulfiram (Antabuse) using selected ion flow tube mass spectrometry (SIFT-MS).

abstract：:Alterations in neural structure have been reported in both cocaine-use disorder and gambling disorder, separately, suggesting similarities across addiction diagnoses. Individual variation in neural structure has also been associated with impulsivity, a dimensional construct implicated in addictions. This study combine...

journal_title：Addiction biology

authors： Yip SW,Worhunsky PD,Xu J,Morie KP,Constable RT,Malison RT,Carroll KM,Potenza MN

更新日期：2018-01-01 00:00:00

abstract：:Frustration represents a particular aspect of the addictive process that is related to loss of control when the expected reward is not obtained. We aim to study the consequences of frustrated expected reward on gene expression in the mouse brain. For this purpose, we used an operant model of frustration using palatabl...

journal_title：Addiction biology

authors： Martín-García E,Fernández-Castillo N,Burokas A,Gutiérrez-Cuesta J,Sánchez-Mora C,Casas M,Ribasés M,Cormand B,Maldonado R

更新日期：2015-01-01 00:00:00

abstract：:Nicotine exerts its rewarding effects by promoting an increase in dopamine (DA) release in the nucleus accumbens (NAc), and this process is influenced by the endocannabinoid system. Fatty acid amide hydrolase (FAAH) is the main enzyme responsible for the degradation of the endocannabinoid anandamide and other non-cann...

journal_title：Addiction biology

authors： Pavon FJ,Serrano A,Sidhpura N,Polis I,Stouffer D,de Fonseca FR,Cravatt BF,Martin-Fardon R,Parsons LH

更新日期：2018-03-01 00:00:00

abstract：:Although adolescents are a group heavily targeted by the e-cigarette industry, research in cue-reactivity has not previously examined adolescents' behavioral and neural responses to e-cigarette advertising. This study addressed this gap through two experiments. In Experiment One, adult traditional cigarette smokers (n...

journal_title：Addiction biology

authors： Chen Y,Fowler CH,Papa VB,Lepping RJ,Brucks MG,Fox AT,Martin LE

更新日期：2018-03-01 00:00:00

abstract：:We measured hippocampal volumes and cognitive functioning in crack-cocaine and crack-cocaine/alcoholdependent subjects (abstinent approximately 10-12 weeks) compared to age-matched controls. Cognitive function was evaluated using the computerized MicroCog Assessment of Cognitive Functioning (which includes tests of ex...

journal_title：Addiction biology

authors： DI Sclafani V,Truran DL,Bloomer C,Tolou-Shams M,Clark HW,Norman D,Hannauer D,Fein G

更新日期：1998-07-01 00:00:00

abstract：:Despite the fact that several data have supported the involvement of the cerebellum in the functional alterations observed after prolonged cocaine use, this brain structure has been traditionally ignored and excluded from the circuitry affected by addictive drugs. In the present study, we investigated the effects of a...

journal_title：Addiction biology

authors： Vazquez-Sanroman D,Leto K,Cerezo-Garcia M,Carbo-Gas M,Sanchis-Segura C,Carulli D,Rossi F,Miquel M

更新日期：2015-09-01 00:00:00

abstract：:Previous research in rodents suggests that the long-term neurobehavioral disturbances induced by chronic ethanol (EtOH) exposure could be due to endocannabinoid system (ECS) alterations. Moreover, ECS failure has been proposed to mediate the cognitive impairment and β-amyloid production in Alzheimer disease (AD). Thus...

journal_title：Addiction biology

authors： Ledesma JC,Rodríguez-Arias M,Gavito AL,Sánchez-Pérez AM,Viña J,Medina Vera D,Rodríguez de Fonseca F,Miñarro J

更新日期：2021-01-01 00:00:00

abstract：:Relapse into drug use is a major problem faced by recovering addicts. In humans, an intensification of the desire for the drug induced by environmental cues-incubation of drug craving-has been observed. In rodents, this phenomenon has been modeled by studying drug seeking under extinction after different times of drug...

journal_title：Addiction biology

authors： Roura-Martínez D,Ucha M,Orihuel J,Ballesteros-Yáñez I,Castillo CA,Marcos A,Ambrosio E,Higuera-Matas A

更新日期：2020-03-01 00:00:00

abstract：:Obesity represents an important risk factor contributing to the global burden of disease. The current obesogenic environment with easy access to calorie-dense foods is fueling this obesity epidemic. However, how these foods contribute to the progression of feeding behavior changes that lead to overeating is not well u...

journal_title：Addiction biology

authors： Espinosa-Carrasco J,Burokas A,Fructuoso M,Erb I,Martín-García E,Gutiérrez-Martos M,Notredame C,Maldonado R,Dierssen M

更新日期：2018-03-01 00:00:00

abstract：:Patients in methadone maintenance programmes (MMT) often smoke tobacco and cannabis and many have ongoing illicit drug use. There is therefore potential for these patients to have abnormal cardiorespiratory function; however, few studies address this in stable MMT patients. We assessed resting cardiorespiratory functi...

journal_title：Addiction biology

authors： Teichtahl H,Wang D,Cunnington D,Kronborg I,Goodman C,Prodromidis A,Drummer O

更新日期：2004-09-01 00:00:00

abstract：:Quitting smoking is notoriously difficult. Models of nicotine dependence posit that strength of cognitive control contributes to maintaining smoking abstinence during smoking cessation attempts. We examine the role for large-scale functional brain systems associated with cognitive control in smoking lapse using a nove...

journal_title：Addiction biology

authors： Lydon-Staley DM,MacLean RR,Falk EB,Bassett DS,Wilson SJ

更新日期：2021-01-28 00:00:00

abstract：:Drugs of abuse induce widespread synaptic adaptations in the mesolimbic dopamine (DA) neurons. Such drug-induced neuroadaptations may constitute an initial cellular mechanism eventually leading to compulsive drug-seeking behavior. To evaluate the impact of GABAB receptors on addiction-related persistent neuroplasticit...

journal_title：Addiction biology

authors： de Miguel E,Vekovischeva O,Kuokkanen K,Vesajoki M,Paasikoski N,Kaskinoro J,Myllymäki M,Lainiola M,Janhunen SK,Hyytiä P,Linden AM,Korpi ER

更新日期：2019-11-01 00:00:00

abstract：:Methamphetamine (METH) is a highly potent and addictive psychostimulant that is frequently abused worldwide. Although the biggest challenge to the efficient treatment of drug dependence is relapse, its mechanism is completely unclear. Plenty of evidence suggests that inflammation contributes to drug-induced reward esp...

journal_title：Addiction biology

authors： Karimi-Haghighi S,Dargahi L,Haghparast A

更新日期：2020-03-01 00:00:00

abstract：:Cigarette smoking is a severe health burden being related to a number of chronic diseases. Frequently, smokers report about sleep problems. Sleep disturbance, in turn, has been demonstrated to be involved in the pathophysiology of several disorders related to smoking and may be relevant for the pathophysiology of nico...

journal_title：Addiction biology

authors： Cohrs S,Rodenbeck A,Riemann D,Szagun B,Jaehne A,Brinkmeyer J,Gründer G,Wienker T,Diaz-Lacava A,Mobascher A,Dahmen N,Thuerauf N,Kornhuber J,Kiefer F,Gallinat J,Wagner M,Kunz D,Grittner U,Winterer G

更新日期：2014-05-01 00:00:00

abstract：:Exposure to drug-associated cues evokes drug-seeking behavior and is regarded as a major cause of relapse. Conditional stimulus upregulates noradrenaline (NA) system activity, but the drug-seeking behavior depends particularly on phasic dopamine signaling downstream from the ventral tegmental area (VTA). The VTA dopam...

journal_title：Addiction biology

authors： Solecki WB,Szklarczyk K,Pradel K,Kwiatkowska K,Dobrzański G,Przewłocki R

更新日期：2018-03-01 00:00:00

abstract：:Positive and negative emotional experiences induced by addictive drugs play an important role in the development of dysfunctional drug-related memory, which becomes resistant to extinction and contributes to high rate of relapse. Those memories may undergo a process called reconsolidation that in some cases can be dis...

journal_title：Addiction biology

authors： Wu Y,Li Y,Yang X,Sui N

更新日期：2014-01-01 00:00:00

abstract：:Methamphetamine (METH) is an increasing popular and highly addictive stimulant associated with autonomic nervous system (ANS) dysfunction, cardiovascular pathology and neurotoxicity. Heart rate variability (HRV) has been used to assess autonomic function and predict mortality in cardiac disorders and drug intoxication...

journal_title：Addiction biology

authors： Henry BL,Minassian A,Perry W

更新日期：2012-05-01 00:00:00

abstract：:The study is designed to clarify the effect of low doses of alcohol on respiratory variables in air breathing normal subjects. Each subject was given an initial loading dose of alcohol (0.270 g/kg) followed, half an hour later, by a second dose (0.135 g/kg). Blood alcohol increased to a mean value of 52.0 +/- 3.0 (SEM...

journal_title：Addiction biology

authors： Wolff CB,Peters TJ,Keating J,Gardner WN

更新日期：1999-04-01 00:00:00

abstract：:We demonstrated that alcohol-dependent patients who relapsed within 1 year after detoxification showed stronger PIT effects compared with abstainers and controls. Relapsers particularly failed to correctly perform in trials where an instrumental stimulus required inhibition while a Pavlovian background cue indicated a...

journal_title：Addiction biology

authors： Sommer C,Birkenstock J,Garbusow M,Obst E,Schad DJ,Bernhardt N,Huys QM,Wurst FM,Weinmann W,Heinz A,Smolka MN,Zimmermann US

更新日期：2020-01-01 00:00:00

abstract：:This study investigated the effects of chronic ethanol intake on hepatic haemodynamics and reticuloendothelial system function in the rat. Comparisons were also made with blood flow to pancreas, kidney, spleen, lung and skin. Male Wistar rats, approximately 0.15 kg initial body weight, were fed a diet containing 35% o...

journal_title：Addiction biology

authors： Preedy VR,Nott DM,Yates J,Venkatesan S,Jenkins SA,Peters TJ

更新日期：1997-10-01 00:00:00

abstract：:Fetal alcohol syndrome (FAS) is an important cause of mental retardation and developmental disabilities. A population based screening tool would allow for early diagnosis and entry into intervention programs. The aim of the study was to develop a brief screening tool for use in population-based settings to improve the...

journal_title：Addiction biology

authors： Burd L,Cox C,Poitra B,Wentz T,Ebertowski M,Martsolf JT,Kerbeshian J,Klug MG

更新日期：1999-07-01 00:00:00

abstract：:The α1 -adrenergic antagonist, doxazosin, has improved cocaine use disorder (CUD) presumably by blocking norepinephrine (NE) stimulation and reward from cocaine-induced NE increases. If the NE levels for release were lower, then doxazosin might more readily block this NE stimulation and be more effective. The NE avail...

journal_title：Addiction biology

authors： Zhang X,Nielsen DA,Domingo CB,Shorter DI,Nielsen EM,Kosten TR

更新日期：2019-05-01 00:00:00

abstract：:The striatum, a major central nervous system structure modulating movement, is enriched with glutamatergic and dopaminergic innervation. By altering activities of both glutamatergic and dopaminergic transmissions the psychostimulants, amphetamine and cocaine, induce behavioral changes in experimental animals. Activati...

journal_title：Addiction biology

authors： Wang JQ,McGinty JF

更新日期：1999-04-01 00:00:00

abstract：:Withdrawal from extended-access cocaine self-administration leads to progressive intensification ('incubation') of cocaine craving. After prolonged withdrawal (1-2 months), when craving is high, expression of incubation depends on strengthening of excitatory inputs to medium spiny neurons (MSN) of the nucleus accumben...

journal_title：Addiction biology

authors： Purgianto A,Weinfeld ME,Wolf ME

更新日期：2017-11-01 00:00:00

abstract：:Numerous studies have explored the morphological differences of the brain between subjects with alcohol use disorder (AUD) and control subjects, but very few have investigated the impact of the duration of alcohol use disorder (DAD) and current level of alcohol consumption (CAC) within AUD subjects using magnetic reso...

journal_title：Addiction biology

authors： Rolland B,Dricot L,Creupelandt C,Maurage P,De Timary P

更新日期：2020-03-01 00:00:00

abstract：:The present study examined the association between a measure of sociopathy and 5-HTTLPR genotype in a sample of individuals from Project MATCH, a multi-center alcohol treatment trial. 5-HTTLPR, an insertion-deletion polymorphism in SLC6A4, the gene encoding the serotonin transporter protein, results in functionally di...

journal_title：Addiction biology

authors： Herman AI,Conner TS,Anton RF,Gelernter J,Kranzler HR,Covault J

更新日期：2011-01-01 00:00:00

abstract：:Propensity to drink alcohol and to initiate binge drinking behavior is driven by genetic factors. Recently, we proposed an original animal model useful in the study of voluntary binge-like drinking (BD) in outbred Long-Evans rats by combining intermittent access to 20% ethanol in a two-bottle choice (IA2BC) paradigm t...

journal_title：Addiction biology

authors： Sauton P,Deschamps C,Jeanblanc V,Pierrefiche O,Jeanblanc J,Naassila M

更新日期：2020-12-16 00:00:00

abstract：:The aim of this study was to profile and compare blood naltrexone and 6-beta-naltrexol levels with time following treatment with two sustained-release naltrexone preparations produced by GoMedical Industries, Australia at a community heroin treatment clinic in Perth, Western Australia. A sample of 10 patients who each...

journal_title：Addiction biology

authors： Hulse GK,Arnold-Reed DE,O'Neil G,Chan CT,Hansson R,O'Neil P

更新日期：2004-03-01 00:00:00

abstract：:Intravenous drug addiction is known to be associated with an inordinate morbidity and mortality. As our previous report had identified an immune phenotype consistent with accelerated ageing, we wished to investigate how much of this change may have been related to chronic viral hepatitis. A total of 12 409 clinical pa...

journal_title：Addiction biology

authors： Reece AS

更新日期：2009-04-01 00:00:00

abstract：:Ketamine, a non-competitive N-methyl-D-aspartic acid receptor antagonist, has emerged as an increasingly popular drug among young drug abusers worldwide. Available evidence suggests that ketamine produces acute impairments of working, episodic and semantic memory along with psychotogenic and dissociative effects when ...

journal_title：Addiction biology

authors： Sun L,Li Q,Li Q,Zhang Y,Liu D,Jiang H,Pan F,Yew DT

更新日期：2014-03-01 00:00:00