Noradrenergic signaling in the VTA modulates cocaine craving.

abstract：:Although substantial research effort has focused on developing pharmacological treatments for cocaine abuse, no effective medications have been developed. Recent studies show that enzymes that metabolize cocaine in the periphery, forestalling its entry into the brain, can prevent cocaine toxicity and its behavioral ef...

journal_title：Addiction biology

authors： Schindler CW,Justinova Z,Lafleur D,Woods D,Roschke V,Hallak H,Sklair-Tavron L,Redhi GH,Yasar S,Bergman J,Goldberg SR

更新日期：2013-01-01 00:00:00

abstract：:Neuroimaging studies suggested that drug addiction is linked to abnormal brain functional connectivity. However, little is known about the alteration of brain white matter (WM) connectivity in addictive drug users and nearly no study has been performed to examine the alterations of brain WM connectivity in heroin-depe...

journal_title：Addiction biology

authors： Zhang R,Jiang G,Tian J,Qiu Y,Wen X,Zalesky A,Li M,Ma X,Wang J,Li S,Wang T,Li C,Huang R

更新日期：2016-05-01 00:00:00

abstract：:In utero exposure of fetuses to tobacco is associated with reduced birth weight. We hypothesized that this may be due to the toxic effect of carbon monoxide (CO) from tobacco, which has previously been described to damage mitochondria in non-pregnant adult smokers. Maternal peripheral blood mononuclear cells (PBMCs), ...

journal_title：Addiction biology

authors： Garrabou G,Hernàndez AS,Catalán García M,Morén C,Tobías E,Córdoba S,López M,Figueras F,Grau JM,Cardellach F

更新日期：2016-01-01 00:00:00

abstract：:Previous research in rodents suggests that the long-term neurobehavioral disturbances induced by chronic ethanol (EtOH) exposure could be due to endocannabinoid system (ECS) alterations. Moreover, ECS failure has been proposed to mediate the cognitive impairment and β-amyloid production in Alzheimer disease (AD). Thus...

journal_title：Addiction biology

authors： Ledesma JC,Rodríguez-Arias M,Gavito AL,Sánchez-Pérez AM,Viña J,Medina Vera D,Rodríguez de Fonseca F,Miñarro J

更新日期：2021-01-01 00:00:00

abstract：:Schizophrenia is a mental disorder characterized by a series of positive, negative or cognitive symptoms but with also the particularity of exhibiting a high rate of co-morbid use of drugs of abuse. While more than 80% of schizophrenics are smokers, the second most consumed drug is alcohol, with dramatic consequences ...

journal_title：Addiction biology

authors： Jeanblanc J,Balguerie K,Coune F,Legastelois R,Jeanblanc V,Naassila M

更新日期：2015-05-01 00:00:00

abstract：:The non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist such as an abused drug phencyclidine (PCP) causes the induction of heat shock protein HSP-70, a sensitive marker of neuronal injury, in the retrosplenial cortex of rat brain. The present study was undertaken to examine the role of a -amino-3- hydroxy-...

journal_title：Addiction biology

authors： Narita N,Hashimoto K,Tomitaka S,Minabe Y,Yamazaki K

更新日期：1997-01-01 00:00:00

abstract：:In light of the upcoming eleventh edition of the International Classification of Diseases (ICD-11), the question arises as to the most appropriate classification of 'Pathological Gambling' ('PG'). Some academic opinion favors leaving PG in the 'Impulse Control Disorder' ('ICD') category, as in ICD-10, whereas others a...

journal_title：Addiction biology

authors： Fauth-Bühler M,Mann K,Potenza MN

更新日期：2017-07-01 00:00:00

abstract：:The capacity of the liver to synthesize insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) may be compromised by alcohol. The characteristics of IGFBP-3 variants obtained from healthy individuals and patients with alcoholic cirrhosis (ALC) were compared. Concanavalin A (Con A) affinity electrophore...

journal_title：Addiction biology

authors： Nedić O,Nikolić JA,Prisić S,Acimovic J,hajdukovic-Dragojlovic L

更新日期：2003-03-01 00:00:00

abstract：:Alcoholic drinks are capable of triggering a wide range of allergic and allergic-like responses, including rhinitis, itching, facial swelling, headache, cough and asthma. Limited epidemiological data suggests that many individuals are affected and that sensitivities occur to a variety of drinks, including wine, beer a...

journal_title：Addiction biology

authors： Vally H,Thompson PJ

更新日期：2003-03-01 00:00:00

abstract：:Numerous studies have explored the morphological differences of the brain between subjects with alcohol use disorder (AUD) and control subjects, but very few have investigated the impact of the duration of alcohol use disorder (DAD) and current level of alcohol consumption (CAC) within AUD subjects using magnetic reso...

journal_title：Addiction biology

authors： Rolland B,Dricot L,Creupelandt C,Maurage P,De Timary P

更新日期：2020-03-01 00:00:00

abstract：:The present study examined the association between a measure of sociopathy and 5-HTTLPR genotype in a sample of individuals from Project MATCH, a multi-center alcohol treatment trial. 5-HTTLPR, an insertion-deletion polymorphism in SLC6A4, the gene encoding the serotonin transporter protein, results in functionally di...

journal_title：Addiction biology

authors： Herman AI,Conner TS,Anton RF,Gelernter J,Kranzler HR,Covault J

更新日期：2011-01-01 00:00:00

abstract：:The administration of cannabidiol has shown promising evidence in the treatment of some neuropsychiatric disorders, including cocaine addiction. However, little information is available as to the mechanisms by which cannabidiol reduces drug use and compulsive seeking. We investigated the role of adult hippocampal neur...

journal_title：Addiction biology

authors： Luján MÁ,Cantacorps L,Valverde O

更新日期：2020-07-01 00:00:00

abstract：:Early relapse is common after opiate withdrawal and deprives addicts of important opportunities to develop new, opiate-free cognitive-behavioural habits. The oral opiate antagonist naltrexone (NTX) significantly reduces relapse only when rigorously supervised and/or probation-linked. Simple but effective NTX implants,...

journal_title：Addiction biology

authors： Foster J,Brewer C,Steele T

更新日期：2003-06-01 00:00:00

abstract：:Cocaine self-administration in rats results in dysfunctional neuroadaptations in the prelimbic (PrL) cortex during early abstinence. Central to these adaptations is decreased phospho-extracellular signal-regulated kinase (p-ERK), which plays a key role in cocaine seeking. Normalizing ERK phosphorylation in the PrL cor...

journal_title：Addiction biology

authors： Siemsen BM,Lombroso PJ,McGinty JF

更新日期：2018-01-01 00:00:00

abstract：:The AA (alko, alcohol) and ANA (alko, non-alcohol) rat lines were among the earliest rodent lines produced by bidirectional selection for ethanol preference. The purpose of this review is to highlight the strategies for understanding the neurobiological factors underlying differential alcohol-drinking behavior in thes...

journal_title：Addiction biology

authors： Sommer W,Hyytiä P,Kiianmaa K

更新日期：2006-09-01 00:00:00

abstract：:Although the notion that alcohol promotes violence is widespread, not all individuals are aggressive while intoxicated. Genetic variation could be a contributing factor to individual differences in alcohol-heightened aggression. The present study examines the effects of OPRM1C77G genotype on responses to threat in rhe...

journal_title：Addiction biology

authors： Driscoll CA,Lindell SG,Schwandt ML,Suomi SJ,Higley JD,Heilig M,Barr CS

更新日期：2017-11-01 00:00:00

abstract：:We examined whether acute administration of phencyclidine (PCP), an antagonist of the N-methyl-D-aspartate (NMDA) receptor-channel complex, can cause neuronal toxicity that is associated with apoptosis. Three- and 24-month-old rats were placed in locomotor activity chambers. PCP (50 mg/kg) or saline (0.15 M NaCl) were...

journal_title：Addiction biology

authors： Milosević J,Veskov R,Vasilev V,Rakić L,Ruzdijić S

更新日期：2000-04-01 00:00:00

abstract：:Activation of brain microglial cells, microgliosis, has been linked to methamphetamine (MA)-seeking behavior, suggesting that microglia could be a new therapeutic target for MA use disorder. Animal data show marked brain microglial activation following acute high-dose MA, but microglial status in human MA users is unc...

journal_title：Addiction biology

authors： Rathitharan G,Truong J,Tong J,McCluskey T,Meyer JH,Mizrahi R,Warsh J,Rusjan P,Kennedy JL,Houle S,Kish SJ,Boileau I

更新日期：2021-01-01 00:00:00

abstract：:Animal research supports a central role for corticotropin-releasing factor (CRF) in actions of ethanol on brain function. An examination of alcohol consumption in adolescents reported a significant genotype x environment (G x E) interaction involving rs1876831, a corticotropin-releasing hormone receptor 1 (CRHR1) poly...

journal_title：Addiction biology

authors： Nelson EC,Agrawal A,Pergadia ML,Wang JC,Whitfield JB,Saccone FS,Kern J,Grant JD,Schrage AJ,Rice JP,Montgomery GW,Heath AC,Goate AM,Martin NG,Madden PA

更新日期：2010-01-01 00:00:00

abstract：:Naltrexone blocks the opioid receptors that modulate the release of dopamine in the brain reward system and therefore blocks the rewarding effects of heroin and alcohol. It is generally assumed that naltrexone leads to reduction of craving, but few studies have been performed to prove this. The purpose of the present ...

journal_title：Addiction biology

authors： Dijkstra BA,De Jong CA,Bluschke SM,Krabbe PF,van der Staak CP

更新日期：2007-06-01 00:00:00

abstract：:The high prevalence of psychostimulant abuse observed in schizophrenic patients may be related to the development of mesolimbic dopaminergic supersensitivity (MDS) or nigrostriatal dopaminergic supersensitivity (NDS) in response to the chronic blockade of dopamine receptors produced by typical neuroleptic treatment. W...

journal_title：Addiction biology

authors： Carvalho RC,Fukushiro DF,Helfer DC,Callegaro-Filho D,Trombin TF,Zanlorenci LH,Sanday L,Silva RH,Frussa-Filho R

更新日期：2009-07-01 00:00:00

abstract：:The Lewis (LEW) and Fischer 344 (F344) inbred rat strains are frequently used to study the role of genetic factors in vulnerability to drug addiction and relapse. Glutamate and γ-amino butyric acid (GABA) transmission are significantly altered after cocaine-induced reinstatement, although whether LEW and F344 rats dif...

journal_title：Addiction biology

authors： Miguéns M,Botreau F,Olías O,Del Olmo N,Coria SM,Higuera-Matas A,Ambrosio E

更新日期：2013-07-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) regulates a variety of physiological processes, and several studies have explored the role of BDNF in addiction-related brain regions like the nucleus accumbens core (NAcore). We sought to understand the rapid effects of endogenous BDNF on cocaine seeking. Rats were trained to ...

journal_title：Addiction biology

authors： Bobadilla AC,Garcia-Keller C,Chareunsouk V,Hyde J,Medina Camacho D,Heinsbroek JA,Kalivas PW

更新日期：2019-09-01 00:00:00

abstract：:The orexin (hypocretin) system plays a critical role in motivated drug taking. Cocaine self-administration with the intermittent access (IntA) procedure produces a robust addiction-like state that is orexin-dependent. Here, we sought to determine the role of the orexin system in opioid addiction using IntA self-admini...

journal_title：Addiction biology

authors： Fragale JE,James MH,Aston-Jones G

更新日期：2020-08-14 00:00:00

abstract：:The striatum, a major central nervous system structure modulating movement, is enriched with glutamatergic and dopaminergic innervation. By altering activities of both glutamatergic and dopaminergic transmissions the psychostimulants, amphetamine and cocaine, induce behavioral changes in experimental animals. Activati...

journal_title：Addiction biology

authors： Wang JQ,McGinty JF

更新日期：1999-04-01 00:00:00

abstract：:Cigarette smoking is a severe health burden being related to a number of chronic diseases. Frequently, smokers report about sleep problems. Sleep disturbance, in turn, has been demonstrated to be involved in the pathophysiology of several disorders related to smoking and may be relevant for the pathophysiology of nico...

journal_title：Addiction biology

authors： Cohrs S,Rodenbeck A,Riemann D,Szagun B,Jaehne A,Brinkmeyer J,Gründer G,Wienker T,Diaz-Lacava A,Mobascher A,Dahmen N,Thuerauf N,Kornhuber J,Kiefer F,Gallinat J,Wagner M,Kunz D,Grittner U,Winterer G

更新日期：2014-05-01 00:00:00

abstract：:Neuroadaptations in the ventral striatum (VS) and ventral midbrain (VMB) following chronic opioid administration are thought to contribute to the pathogenesis and persistence of opiate addiction. In order to identify candidate genes involved in these neuroadaptations, we utilized a behavior-genetics strategy designed ...

journal_title：Addiction biology

authors： Tapocik JD,Luu TV,Mayo CL,Wang BD,Doyle E,Lee AD,Lee NH,Elmer GI

更新日期：2013-05-01 00:00:00

abstract：:Several studies show that substance dependence disorders are characterized by an enhanced processing of substance-related stimuli. The present study was designed to examine the association between craving levels and selective processing of drug cues in cocaine-dependent patients using event-related brain potentials (E...

journal_title：Addiction biology

authors： Franken IH,Dietvorst RC,Hesselmans M,Franzek EJ,van de Wetering BJ,Van Strien JW

更新日期：2008-09-01 00:00:00

abstract：:Ketamine, a non-competitive N-methyl-D-aspartic acid receptor antagonist, has emerged as an increasingly popular drug among young drug abusers worldwide. Available evidence suggests that ketamine produces acute impairments of working, episodic and semantic memory along with psychotogenic and dissociative effects when ...

journal_title：Addiction biology

authors： Sun L,Li Q,Li Q,Zhang Y,Liu D,Jiang H,Pan F,Yew DT

更新日期：2014-03-01 00:00:00

abstract：:We demonstrated that the genotype of the variable number tandem repeats (VNTRs) in the linked polymorphic region (LPR) of the 5' promoter and in the intron 2 (Stin2) transcriptional regulatory domains of the serotonin transporter SLC6A4 gene determined its promoter interactions with transcription factors and co-activa...

journal_title：Addiction biology

authors： Vasiliou SA,Ali FR,Haddley K,Cardoso MC,Bubb VJ,Quinn JP

更新日期：2012-01-01 00:00:00