Abstract:
:The orexin (hypocretin) system plays a critical role in motivated drug taking. Cocaine self-administration with the intermittent access (IntA) procedure produces a robust addiction-like state that is orexin-dependent. Here, we sought to determine the role of the orexin system in opioid addiction using IntA self-administration of fentanyl. Different groups of male rats were either given continuous access in 1-h period (short access [ShA]), 6-h period (long access [LgA]), or IntA (5 min of access separated by 25 min of no access for 6 h) to fentanyl for 14 days. IntA produced a greater escalation of fentanyl intake, increased motivation for fentanyl on a behavioral economics task, persistent drug seeking during abstinence, and stronger cue-induced reinstatement compared with rats given ShA or LgA. We found that addiction behaviors induced by IntA to fentanyl were reversed by the orexin-1 receptor antagonist SB-334867. IntA to fentanyl was also associated with a persistent increase in the number of orexin neurons. Together, these results indicate that the IntA model is a useful tool in the study of opioid addiction and that the orexin system is critical for the maintenance of addiction behaviors induced by IntA self-administration of fentanyl.
journal_name
Addict Bioljournal_title
Addiction biologyauthors
Fragale JE,James MH,Aston-Jones Gdoi
10.1111/adb.12946subject
Has Abstractpub_date
2020-08-14 00:00:00pages
e12946eissn
1355-6215issn
1369-1600pub_type
杂志文章abstract::Early relapse is common after opiate withdrawal and deprives addicts of important opportunities to develop new, opiate-free cognitive-behavioural habits. The oral opiate antagonist naltrexone (NTX) significantly reduces relapse only when rigorously supervised and/or probation-linked. Simple but effective NTX implants,...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/1355621031000117446
更新日期:2003-06-01 00:00:00
abstract::Previous research in rodents suggests that the long-term neurobehavioral disturbances induced by chronic ethanol (EtOH) exposure could be due to endocannabinoid system (ECS) alterations. Moreover, ECS failure has been proposed to mediate the cognitive impairment and β-amyloid production in Alzheimer disease (AD). Thus...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12883
更新日期:2021-01-01 00:00:00
abstract::We measured hippocampal volumes and cognitive functioning in crack-cocaine and crack-cocaine/alcoholdependent subjects (abstinent approximately 10-12 weeks) compared to age-matched controls. Cognitive function was evaluated using the computerized MicroCog Assessment of Cognitive Functioning (which includes tests of ex...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556219872074
更新日期:1998-07-01 00:00:00
abstract::Impulsive delayed reward discounting (DRD) is an important behavioral process in alcohol use disorders (AUDs), reflecting incapacity to delay gratification. Recent work in neuroeconomics has begun to unravel the neural mechanisms supporting DRD, but applications of neuroeconomics in relation to AUDs have been limited....
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12017
更新日期:2014-07-01 00:00:00
abstract::Poor working memory is linked to future risk-taking behaviors. Lifelong risk of habitual drug use is highest in individuals who initiate use in early adolescence. We sought to determine in rats whether juvenile traits, specifically poor working memory and low salivary brain-derived neurotrophic factor (BDNF), are rela...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12535
更新日期:2018-05-01 00:00:00
abstract::This study evaluated the effects of cannabidiol (CBD) on ethanol reinforcement, motivation and relapse in C57BL/6 J mice. The effects of CBD (60 mg/kg, i.p.) on blood ethanol concentration, hypothermia and handling-induced convulsions associated to acute ethanol administration were evaluated. The two-bottle choice par...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12495
更新日期:2018-01-01 00:00:00
abstract::Mixing alcohol with caffeinated energy drinks is a common practice, especially among young people. In humans, the research on this issue has mainly focused on the use of the mass-marketed energy drinks themselves, whereas in animal models, it has focused on the individual effects of their active ingredients (i.e. caff...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12560
更新日期:2018-09-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12820
更新日期:2020-07-01 00:00:00
abstract::Methamphetamine (METH) is a highly potent and addictive psychostimulant that is frequently abused worldwide. Although the biggest challenge to the efficient treatment of drug dependence is relapse, its mechanism is completely unclear. Plenty of evidence suggests that inflammation contributes to drug-induced reward esp...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12740
更新日期:2020-03-01 00:00:00
abstract::Abstract Methamphetamine (METH)-induced dopaminergic neurotoxicity is thought to be associated with the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS). Recently, we have reported that copper/zinc(CuZn)-superoxide dismutase transgenic mice are resistant to METH-induced neurotoxicity. In...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2000.tb00200.x
更新日期:2000-07-01 00:00:00
abstract::Chemical compounds that target dopamine (DA) D1 or D3 receptors have shown promise as potential interventions in animal models of cue-induced relapse. However, undesirable side effects or pharmacodynamic profiles have limited the advancement of new compounds in preclinical studies when administered as independent trea...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12988
更新日期:2021-01-25 00:00:00
abstract::Extracellular glycine modulates accumbal dopamine levels as well as ethanol-induced dopamine overflow. Glycine availability is also crucial for regulating alcohol consumption and the glycine transporter 1 (GlyT-1) inhibitor Org25935 robustly decreases alcohol intake in rats. To explore whether the alcohol-intake reduc...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2011.00367.x
更新日期:2012-09-01 00:00:00
abstract::We examined whether acute administration of phencyclidine (PCP), an antagonist of the N-methyl-D-aspartate (NMDA) receptor-channel complex, can cause neuronal toxicity that is associated with apoptosis. Three- and 24-month-old rats were placed in locomotor activity chambers. PCP (50 mg/kg) or saline (0.15 M NaCl) were...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556210050003748
更新日期:2000-04-01 00:00:00
abstract::Several genetic polymorphisms have been reported to be associated with alcohol withdrawal seizures (AWS) and delirium tremens (DT). To replicate and further explore these findings, we investigated the effects of 12 previously reported candidate genetic variations in two groups of alcohol-dependent European Americans w...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2009.00183.x
更新日期:2010-01-01 00:00:00
abstract::The purpose of this study was to evaluate the effects of naltrexone (0.7 mg/kg) and/or topiramate (25 mg/kg) on ethanol consumption and the motivation to drink in an oral-operant conditioning paradigm in C57BL/6 mice. Subsequent real-time polymerase chain reaction (PCR) experiments were performed to analyze gene expre...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12058
更新日期:2014-09-01 00:00:00
abstract::Alcohol exposure during fetal and early postnatal development can lead to an increased incidence of later life adult-onset diseases. Examples include central nervous system dysfunction, depression, anxiety, hyperactivity, and an inability to deal with stressful situations, increased infection and cancer. Direct effect...
journal_title:Addiction biology
pub_type: 杂志文章,评审
doi:10.1111/adb.12186
更新日期:2016-01-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12798
更新日期:2020-09-01 00:00:00
abstract::Although the involvement of dopamine in gambling disorder (GD) has long been hypothesized, its precise role remains unclear. The action of dopamine in the synapses is regulated by the dopamine transporter (DAT). We hereinafter present significant differences between a sample of 15 treatment-seeking GD subjects and 17 ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12677
更新日期:2019-09-01 00:00:00
abstract::The study is designed to clarify the effect of low doses of alcohol on respiratory variables in air breathing normal subjects. Each subject was given an initial loading dose of alcohol (0.270 g/kg) followed, half an hour later, by a second dose (0.135 g/kg). Blood alcohol increased to a mean value of 52.0 +/- 3.0 (SEM...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556219971740
更新日期:1999-04-01 00:00:00
abstract::Erythroycte delta aminolevulinic acid dehydratase (ALAD) has been suggested as a marker for detecting recent alcohol intake. Unlike other markers, ALAD activity decreases after alcohol intake. Review of the literature suggests that the main interest in this marker is because it increases rapidly after withdrawal. The ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556219772778
更新日期:1997-04-01 00:00:00
abstract::Methamphetamine (METH) markedly increases dopamine (DA) release in the mesolimbic DA system, which plays an important role in mediating the reinforcing effects of METH. METH-induced DA release results in the formation of reactive oxygen species (ROS), leading to oxidative damage. We have recently reported that ROS are...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12419
更新日期:2017-09-01 00:00:00
abstract::It has been hypothesized that neural reactivity to drug cues in certain limbic/paralimbic regions of the brain is an indicator of addiction severity and a marker for likelihood of success in treatment. To address this question, in the current study, 32 participants (44 percent female) completed a functional magnetic r...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12549
更新日期:2018-09-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2011.00337.x
更新日期:2011-10-01 00:00:00
abstract::The habit of chewing fresh leaves and twigs of khat (Catha edulis) for their stimulating amphetamine-like effects is highly prevalent in East Africa and southwest on the Arabic peninsula. There is an extensive literature on khat providing information about its history, botany, production, geographical distribution, ch...
journal_title:Addiction biology
pub_type: 杂志文章,评审
doi:10.1080/13556210500353020
更新日期:2005-12-01 00:00:00
abstract::α-Synuclein has recently been implicated in the pathophysiology of alcohol abuse due to its role in dopaminergic neurotransmission. In these studies, genetic variability in the α-synuclein gene influences its expression which may contribute to susceptibility to chronic alcohol abuse. Real-time PCR was used to quantify...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2012.00495.x
更新日期:2014-05-01 00:00:00
abstract::Transferrin (T f) and its carbohydrate-deficient isoform (CDT) were measured by radioimmunoassay in phosphate-buffered saline extracts of two informative areas of cerebral cortex tissue obtained at autopsy from alcoholics without other associated disease (n = 4); alcoholics with cirrhosis of the liver (n = 4) and agem...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556219772633
更新日期:1997-07-01 00:00:00
abstract::Cocaine addiction has been associated with increased sensitivity of the human reward circuit to drug-related stimuli. However, the capacity of non-drug incentives to engage this network is poorly understood. Here, we characterized the functional sensitivity to monetary incentives and the structural integrity of the hu...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12356
更新日期:2017-05-01 00:00:00
abstract::Previous findings have shown that sigma-1 receptors (Sig-1Rs) are upregulated by the self-administration of methamphetamine, whereas Sig-1R antisense can attenuate the behavioral effects of psychostimulants in rodents. Sig-1R is an endoplasmic reticulum chaperone protein. However, the effects of Sig-1R agonist on the ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2012.00488.x
更新日期:2014-05-01 00:00:00
abstract::Use of human laboratory analogues of smoking behavior can provide an efficient, cost-effective mechanistic evaluation of a medication signal on smoking behavior, with the result of facilitating translational work in medications development. Although a number of human laboratory models exist to investigate various aspe...
journal_title:Addiction biology
pub_type: 杂志文章,评审
doi:10.1111/j.1369-1600.2008.00135.x
更新日期:2009-01-01 00:00:00
abstract::Identifying addicts with higher risk of relapse would provide the opportunity to implement individualized interventions and increase cessation success rates. Unfortunately, the ability to predict the long-term success of drug cessation treatments continues to elude researchers. We tested whether brain responses to emo...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2011.00372.x
更新日期:2012-11-01 00:00:00