Abstract:
:Naltrexone blocks the opioid receptors that modulate the release of dopamine in the brain reward system and therefore blocks the rewarding effects of heroin and alcohol. It is generally assumed that naltrexone leads to reduction of craving, but few studies have been performed to prove this. The purpose of the present study was to examine the effect of the administration of naltrexone on craving level after rapid opioid detoxification induced by naltrexone. A naturalistic study was carried out in which patients were followed during 10 months after rapid detoxification. Data about abstinence, relapse, and naltrexone use were collected by means of urine specimens. Craving was measured by the visual analogue scale craving, the Obsessive Compulsive Drug Use Scale, and the Desires for Drug Questionnaire. Results showed that patients who relapsed in opioid use experienced obviously more craving than abstinent people. Patients who took naltrexone did not experience significant less craving than those who did not. These results suggest that the use of opioids is associated with increased craving and that abstinence for opioids is associated with less craving, independent of the use of naltrexone. This is in contrast to the general opinion. Because of the naturalistic design of the study, no firm conclusions can be drawn, but the results grounded the needs of an experimental study.
journal_name
Addict Bioljournal_title
Addiction biologyauthors
Dijkstra BA,De Jong CA,Bluschke SM,Krabbe PF,van der Staak CPdoi
10.1111/j.1369-1600.2007.00067.xsubject
Has Abstractpub_date
2007-06-01 00:00:00pages
176-82issue
2eissn
1355-6215issn
1369-1600pii
ADB067journal_volume
12pub_type
杂志文章abstract::Neuroimaging of opiate-dependent individuals indicates both altered brain structure and function. Magnetic resonance-based arterial spin labeling has been used to measure noninvasively cerebral blood flow (i.e. perfusion) in alcohol, tobacco and stimulant dependence; only one arterial spin labeling paper in opiate-dep...
journal_title:Addiction biology
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pub_type: 杂志文章
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更新日期:2010-07-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
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journal_title:Addiction biology
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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