Abstract:
:Chemical compounds that target dopamine (DA) D1 or D3 receptors have shown promise as potential interventions in animal models of cue-induced relapse. However, undesirable side effects or pharmacodynamic profiles have limited the advancement of new compounds in preclinical studies when administered as independent treatments. In this series of experiments, we explored the effects of coadministration of a D1-receptor partial agonist (SKF 77434) and a D3-receptor antagonist (NGB 2904) in heroin-seeking rats within a "conflict" model of abstinence and cue-induced relapse. Rats were first trained to press a lever to self-administer heroin, and drug delivery was paired contingently with cues (e.g., light and pump noise). Self-initiated abstinence was facilitated by applying electrical current to the flooring in front of the levers. Lastly, a relapse response was provoked by noncontingent presentation of conditioned cues. Prior to provocation, rats received a systemic injection of SKF 77434, NGB 2904, or a combination of both compounds to assess treatment effects on lever pressing. Results indicated that the coadministration of low (i.e., independently ineffective) doses of both compounds was more effective in reducing cue-induced relapse to heroin seeking than either compound alone, with some evidence of drug synergism. Follow-up studies indicated that this reduction was not due to motoric impairment nor enhanced sensitivity to the electrified flooring and that this treatment did not significantly affect motivation for food. Implications for the treatment of opiate use disorder and recommendations for further research are discussed.
journal_name
Addict Bioljournal_title
Addiction biologyauthors
Ewing ST,Dorcely C,Maidi R,Paker G,Schelbaum E,Ranaldi Rdoi
10.1111/adb.12988subject
Has Abstractpub_date
2021-01-25 00:00:00pages
e12988eissn
1355-6215issn
1369-1600pub_type
杂志文章abstract::Repeated or even a single exposure to drugs of abuse can lead to persistent locomotor sensitization, which is the result of an abundance of neuroplastic changes occurring within the circuitry involved in motivational behavior and is thought to play a key role in certain aspects of drug addiction. There is substantial ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2011.00341.x
更新日期:2011-10-01 00:00:00
abstract::Maladaptive cortical plasticity has been described in individuals with heroin and methamphetamine addiction and may mediate other substance abuse disorders. It is unknown whether cannabis dependence in humans alters the capacity for induction of cortical plasticity. The aim of this study was to non-invasively investig...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12912
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556219872344
更新日期:1998-01-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12798
更新日期:2020-09-01 00:00:00
abstract::Use of human laboratory analogues of smoking behavior can provide an efficient, cost-effective mechanistic evaluation of a medication signal on smoking behavior, with the result of facilitating translational work in medications development. Although a number of human laboratory models exist to investigate various aspe...
journal_title:Addiction biology
pub_type: 杂志文章,评审
doi:10.1111/j.1369-1600.2008.00135.x
更新日期:2009-01-01 00:00:00
abstract::Individuals suffering from substance use disorder often experience relapse events that are attributed to drug craving. Insular cortex (IC) function is implicated in processing drug-predictive cues and is thought to be a critical substrate for drug craving, but the downstream neural circuit effectors of the IC that med...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12961
更新日期:2020-08-20 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2012.00507.x
更新日期:2014-03-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12677
更新日期:2019-09-01 00:00:00
abstract::Intravenous drug addiction is known to be associated with an inordinate morbidity and mortality. As our previous report had identified an immune phenotype consistent with accelerated ageing, we wished to investigate how much of this change may have been related to chronic viral hepatitis. A total of 12 409 clinical pa...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2008.00123.x
更新日期:2009-04-01 00:00:00
abstract::Activation of brain microglial cells, microgliosis, has been linked to methamphetamine (MA)-seeking behavior, suggesting that microglia could be a new therapeutic target for MA use disorder. Animal data show marked brain microglial activation following acute high-dose MA, but microglial status in human MA users is unc...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12876
更新日期:2021-01-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2007.00092.x
更新日期:2008-03-01 00:00:00
abstract::Previous research in rodents suggests that the long-term neurobehavioral disturbances induced by chronic ethanol (EtOH) exposure could be due to endocannabinoid system (ECS) alterations. Moreover, ECS failure has been proposed to mediate the cognitive impairment and β-amyloid production in Alzheimer disease (AD). Thus...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12883
更新日期:2021-01-01 00:00:00
abstract::The non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist such as an abused drug phencyclidine (PCP) causes the induction of heat shock protein HSP-70, a sensitive marker of neuronal injury, in the retrosplenial cortex of rat brain. The present study was undertaken to examine the role of a -amino-3- hydroxy-...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556219772859
更新日期:1997-01-01 00:00:00
abstract::Mixing alcohol with caffeinated energy drinks is a common practice, especially among young people. In humans, the research on this issue has mainly focused on the use of the mass-marketed energy drinks themselves, whereas in animal models, it has focused on the individual effects of their active ingredients (i.e. caff...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12560
更新日期:2018-09-01 00:00:00
abstract::Smoking-related cues elicit craving and mesocorticolimbic brain activation in smokers. Severity of nicotine dependence seems to moderate cue reactivity, but the direction and mechanisms of its influence remains unclear. Although tobacco control policies demand a ban on tobacco advertising, cue reactivity studies in sm...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2010.00207.x
更新日期:2011-01-01 00:00:00
abstract::Chronic and excessive alcohol consumption induces defined myocardial lesions characterized by impaired structural, mechanical and biochemical features. The pathogenic mechanisms are unknown, although it is possible that protein adduct formation by reactive metabolites of ethanol may be a contributory process. Hitherto...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2000.tb00211.x
更新日期:2000-10-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12558
更新日期:2018-09-01 00:00:00
abstract::Caffeine has cognitive-enhancing properties with effects on learning and memory, concentration, arousal and mood. These effects imply changes at circuital and synaptic level, but the mechanism by which caffeine modifies synaptic plasticity remains elusive. Here we report that caffeine, at concentrations representing m...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12433
更新日期:2017-11-01 00:00:00
abstract::Ethyl glucuronide (EtG) is a promising new biological state marker of recent alcohol consumption that detects alcohol use reliably over a definite time period. Other currently available markers lack acceptable sensitivity and specificity. Our aim is to elucidate under naturalistic conditions the time course of EtG exc...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/1355621021000006035
更新日期:2002-10-01 00:00:00
abstract::In light of the upcoming eleventh edition of the International Classification of Diseases (ICD-11), the question arises as to the most appropriate classification of 'Pathological Gambling' ('PG'). Some academic opinion favors leaving PG in the 'Impulse Control Disorder' ('ICD') category, as in ICD-10, whereas others a...
journal_title:Addiction biology
pub_type: 杂志文章,评审
doi:10.1111/adb.12378
更新日期:2017-07-01 00:00:00
abstract::Polymorphism of a variable number of tandem repeats (VNTR) in the 3' untranslated region of exon 15 of the SLC6A3 gene, coding for the dopamine transporter (DAT), was analysed to test whether length variation contributes to differences in the individual susceptibility to aggressive - criminal behaviour and liability t...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556210500223769
更新日期:2005-09-01 00:00:00
abstract::Exposure to drug-associated cues evokes drug-seeking behavior and is regarded as a major cause of relapse. Conditional stimulus upregulates noradrenaline (NA) system activity, but the drug-seeking behavior depends particularly on phasic dopamine signaling downstream from the ventral tegmental area (VTA). The VTA dopam...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12514
更新日期:2018-03-01 00:00:00
abstract::Extracellular glycine modulates accumbal dopamine levels as well as ethanol-induced dopamine overflow. Glycine availability is also crucial for regulating alcohol consumption and the glycine transporter 1 (GlyT-1) inhibitor Org25935 robustly decreases alcohol intake in rats. To explore whether the alcohol-intake reduc...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2011.00367.x
更新日期:2012-09-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556210071289
更新日期:2000-01-01 00:00:00
abstract::Abstract Methamphetamine (METH)-induced dopaminergic neurotoxicity is thought to be associated with the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS). Recently, we have reported that copper/zinc(CuZn)-superoxide dismutase transgenic mice are resistant to METH-induced neurotoxicity. In...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2000.tb00200.x
更新日期:2000-07-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/j.1369-1600.2010.00247.x
更新日期:2010-10-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556219971740
更新日期:1999-04-01 00:00:00
abstract::Certain single nucleotide polymorphisms (SNPs) in genes encoding alcohol dehydrogenase (ADH) enzymes confer a significant protective effect against alcohol dependence syndrome (ADS) in East Asian populations. Recently, attention has focused on the role of these SNPs in determining ADS risk in European populations. To ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12141
更新日期:2015-05-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556219872074
更新日期:1998-07-01 00:00:00
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journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1080/13556219971407
更新日期:1999-10-01 00:00:00