Caffeine-mediated BDNF release regulates long-term synaptic plasticity through activation of IRS2 signaling.

abstract：:Betel quid chewing has been claimed to produce a sense of well-being, euphoria, warm sensation of the body, sweating, salivation, palpitation, heightened alertness and increased capacity to work. These effects suggest that betel quid chewing affects predominantly the central and autonomic nervous systems. Several stud...

journal_title：Addiction biology

authors： Chu NS

更新日期：2002-01-01 00:00:00

abstract：:Variations in pattern and extent of cognitive and motor impairment occur in alcoholism (ALC). Causes of such heterogeneity are elusive and inconsistently accounted for by demographic or alcohol consumption differences. We examined neurological and nutritional factors as possible contributors to heterogeneity in impair...

journal_title：Addiction biology

authors： Fama R,Le Berre AP,Hardcastle C,Sassoon SA,Pfefferbaum A,Sullivan EV,Zahr NM

更新日期：2019-03-01 00:00:00

abstract：:While the exact physiological mechanisms underlying cocaine dependence remain unclear, a growing body of evidence indicates a role for the serotonergic neurotransmitter system in the pathology of this substance use disorder. The focus of the present study is to determine whether genetic variation in the tryptophan hyd...

journal_title：Addiction biology

authors： Dahl JP,Cubells JF,Ray R,Weller AE,Lohoff FW,Ferraro TN,Oslin DW,Kampman KM,Dackis C,Tang Y,Gelernter J,Kranzler HR,O'Brien CP,Berrettini WH

更新日期：2006-03-01 00:00:00

abstract：:The posterior hippocampus (pHp) plays a major role in the processing and storage of drug-related cues and is linked to striatal-limbic brain circuits involved with craving and drug salience. We have recently reported that increased basal regional cerebral blood flow (rCBF) in a pHp loci, as measured by pseudo-continuo...

journal_title：Addiction biology

authors： Adinoff B,Harris TS,Gu H,Stein EA

更新日期：2017-05-01 00:00:00

abstract：:Cigarette-dependent smokers automatically and involuntarily orient attention toward smoking cues (SCs). This attentional bias is clinically significant, as it may contribute to relapse. Thus, identifying neural and genetic correlates of attentional bias is critical for improving interventions. Our previous studies sho...

journal_title：Addiction biology

authors： Wetherill RR,Jagannathan K,Lohoff FW,Ehrman R,O'Brien CP,Childress AR,Franklin TR

更新日期：2014-03-01 00:00:00

abstract：:Maladaptive cortical plasticity has been described in individuals with heroin and methamphetamine addiction and may mediate other substance abuse disorders. It is unknown whether cannabis dependence in humans alters the capacity for induction of cortical plasticity. The aim of this study was to non-invasively investig...

journal_title：Addiction biology

authors： Martin-Rodriguez JF,Ruiz-Veguilla M,Alvarez de Toledo P,Aizpurua-Olaizola O,Zarandona I,Canal-Rivero M,Rodriguez-Baena A,Mir P

更新日期：2020-04-23 00:00:00

abstract：:Heavy alcohol use reduces the levels of the brain-derived neurotrophic factor (BDNF) in the prefrontal cortex of rodents through the upregulation of microRNAs (miRs) targeting BDNF mRNA. In humans, an inverse correlation exists between circulating blood levels of BDNF and the severity of psychiatric disorders includin...

journal_title：Addiction biology

authors： Ehinger Y,Phamluong K,Darevesky D,Welman M,Moffat JJ,Sakhai SA,Whiteley EL,Berger AL,Laguesse S,Farokhnia M,Leggio L,Lordkipanidzé M,Ron D

更新日期：2020-03-05 00:00:00

abstract：:Withdrawal of opioid drugs leads to a cluster of unpleasant symptoms in dependent subjects. These symptoms are stimulatory in nature and oppose the acute, inhibitory effects of opiates. The conventional theory that explains the opioid withdrawal syndrome assumes that chronic usage of opioid drugs activates compensator...

journal_title：Addiction biology

authors： Rubovitch V,Pick CG,Sarne Y

更新日期：2009-09-01 00:00:00

abstract：:Abstract Alcoholic liver disease (ALD) is still a frequent disorder, even though its incidence appears to be decreasing. In spite of intense investigation, the precise mechanisms leading to ALD are still imprecisely known. This is due in part to the lack of a reliable animal model; in part to the difficulty of obtaini...

journal_title：Addiction biology

authors： Bellentani S,Saccoccio G,Masutti F,Giacca M,Miglioli L,Monzoni A,Tiribelli C

更新日期：2000-07-01 00:00:00

abstract：:The co-occurrence of chronic pain and alcohol use disorders (AUDs) involves complex interactions between genetic and neurophysiological aspects, and the research has reported mixed findings when they both co-occur. There is also an indication of a gender-dependent effect; males are more likely to use alcohol to cope w...

journal_title：Addiction biology

authors： Bilbao A,Leixner S,Wei S,Cantacorps L,Valverde O,Spanagel R

更新日期：2019-09-01 00:00:00

abstract：:A major finding--that (-)-trans-Delta(9)-tetrahydrocannabinol (Delta(9)-THC) is largely responsible for the psychotropic effects of cannabis--prompted research in the 1970s and 1980s that led to the discovery that this plant cannabinoid acts through at least two types of cannabinoid receptor, CB(1) and CB(2), and that...

journal_title：Addiction biology

authors： Pertwee RG

更新日期：2008-06-01 00:00:00

abstract：:The high prevalence of psychostimulant abuse observed in schizophrenic patients may be related to the development of mesolimbic dopaminergic supersensitivity (MDS) or nigrostriatal dopaminergic supersensitivity (NDS) in response to the chronic blockade of dopamine receptors produced by typical neuroleptic treatment. W...

journal_title：Addiction biology

authors： Carvalho RC,Fukushiro DF,Helfer DC,Callegaro-Filho D,Trombin TF,Zanlorenci LH,Sanday L,Silva RH,Frussa-Filho R

更新日期：2009-07-01 00:00:00

abstract：:Substance use disorder is a complex disease created in part by maladaptive learning and memory mechanisms following repeated drug use. Exposure to drug-associated stimuli engages prefrontal cortex circuits, and dysfunction of the medial prefrontal cortex (mPFC) is thought to underlie drug-seeking behaviors. Growing ev...

journal_title：Addiction biology

authors： Jorgensen ET,Gonzalez AE,Harkness JH,Hegarty DM,Thakar A,Burchi DJ,Aadland JA,Aicher SA,Sorg BA,Brown TE

更新日期：2020-08-04 00:00:00

abstract：:Long-term alcohol use affects cognitive and neurophysiological functioning as well as structural brain development. Combining simultaneous electroencephalogram (EEG) recording with transcranial magnetic stimulation (TMS) enables direct, in vivo exploration of cortical excitability and assessment of effective and funct...

journal_title：Addiction biology

authors： Kaarre O,Kallioniemi E,Könönen M,Tolmunen T,Kekkonen V,Kivimäki P,Heikkinen N,Ferreri F,Laukkanen E,Määttä S

更新日期：2018-01-01 00:00:00

abstract：:Converging evidence indicates that epigenetic mechanisms are involved in drug addiction, and that enzymes involved in chromatin remodeling may represent interesting targets in addiction treatment. No study has addressed whether histone deacetylase (HDAC) inhibitors (HDACi) can reduce excessive ethanol intake or preven...

journal_title：Addiction biology

authors： Simon-O'Brien E,Alaux-Cantin S,Warnault V,Buttolo R,Naassila M,Vilpoux C

更新日期：2015-07-01 00:00:00

abstract：:Numerous studies have explored the morphological differences of the brain between subjects with alcohol use disorder (AUD) and control subjects, but very few have investigated the impact of the duration of alcohol use disorder (DAD) and current level of alcohol consumption (CAC) within AUD subjects using magnetic reso...

journal_title：Addiction biology

authors： Rolland B,Dricot L,Creupelandt C,Maurage P,De Timary P

更新日期：2020-03-01 00:00:00

abstract：:Two analytical techniques (RIA and GC-MS) were used for the simultaneous identification and determination of heroin, cocaine and their metabolites in the urine and hair of 200 drug addicts. Opiates tests were positive in 182 hair samples and 145 urine samples, whereas cocaine tests were positive in 173 hair samples an...

journal_title：Addiction biology

authors： Tabernero MJ,Bermejo AM,Fernandez P

更新日期：1999-10-01 00:00:00

abstract：:Adolescence is characterized by considerable brain maturation that coincides with the development of adult behavior. Binge drinking is common during adolescence and can have deleterious effects on brain maturation because of the heightened neuroplasticity of the adolescent brain. Using an animal model of adolescent in...

journal_title：Addiction biology

authors： Vetreno RP,Yaxley R,Paniagua B,Crews FT

更新日期：2016-07-01 00:00:00

abstract：:Animal research supports a central role for corticotropin-releasing factor (CRF) in actions of ethanol on brain function. An examination of alcohol consumption in adolescents reported a significant genotype x environment (G x E) interaction involving rs1876831, a corticotropin-releasing hormone receptor 1 (CRHR1) poly...

journal_title：Addiction biology

authors： Nelson EC,Agrawal A,Pergadia ML,Wang JC,Whitfield JB,Saccone FS,Kern J,Grant JD,Schrage AJ,Rice JP,Montgomery GW,Heath AC,Goate AM,Martin NG,Madden PA

更新日期：2010-01-01 00:00:00

abstract：:It has been suggested that the attention towards alcohol-related stimuli increases with the duration of drinking and alcohol dependence. The present study aimed to assess whether an attentional bias was present in detoxified alcohol-dependent patients, and if the magnitude of the attentional bias depended on the subje...

journal_title：Addiction biology

authors： Loeber S,Vollstädt-Klein S,von der Goltz C,Flor H,Mann K,Kiefer F

更新日期：2009-04-01 00:00:00

abstract：:Because of its primary role in drug-seeking, consumption and addictive behaviour, there is a growing interest in identifying the neural circuits and molecular mechanisms underlying the formation, maintenance and retrieval of drug-related memories. Human studies, which focused on neuronal systems that store and control...

journal_title：Addiction biology

authors： Carbo-Gas M,Vazquez-Sanroman D,Aguirre-Manzo L,Coria-Avila GA,Manzo J,Sanchis-Segura C,Miquel M

更新日期：2014-01-01 00:00:00

abstract：:Abstract Twenty-eight Wistar rats treated orally with 20% ethanol solution, were divided into two groups: adult group (n = 19) and aged group (n = 9) consisting of animals aged 4 and 12 months, respectively, at the beginning of the treatment. Neurons from the basal nucleus region were counted and the percentage of cho...

journal_title：Addiction biology

authors： Fernandes PA,Ribeiro AM,Pereira RF,Marra HL,Pittella JE

更新日期：2002-01-01 00:00:00

abstract：:The present study was undertaken to examine whether genetically predetermined differences in components of the endocannabinoid system were present in the brain of Sardinian alcohol-preferring (sP) and Sardinian alcohol-non-preferring (sNP) rats, a pair of rat lines selectively bred for opposite alcohol preference. The...

journal_title：Addiction biology

authors： Vinod KY,Maccioni P,Garcia-Gutierrez MS,Femenia T,Xie S,Carai MA,Manzanares J,Cooper TB,Hungund BL,Colombo G

更新日期：2012-01-01 00:00:00

abstract：:Nicotine withdrawal is associated with subtle working memory deficits that predict subsequent relapse. We examined the neural substrates underlying these processes in treatment-seeking smokers, and explored the moderating influence of age on abstinence-induced alterations in brain activity and performance. Sixty-three...

journal_title：Addiction biology

authors： Falcone M,Wileyto EP,Ruparel K,Gerraty RT,LaPrate L,Detre JA,Gur R,Loughead J,Lerman C

更新日期：2014-09-01 00:00:00

abstract：:Alcohol dependence (AD) affects individuals from all racial/ethnic groups, and previous research suggests that there is considerable variation in AD risk between and among various ancestrally defined groups in the United States. Although the reasons for these differences are likely due in part to contributions of comp...

journal_title：Addiction biology

authors： Brick LA,Keller MC,Knopik VS,McGeary JE,Palmer RHC

更新日期：2019-01-01 00:00:00

abstract：:Chronic inhalation of volatile solvents induce severe brain damage. In humans, intense exposure to volatile solvents for recreational purposes is frequently associated with chronic malnutrition. We studied in rats the effects of chronic inhalation of volatile solvents and malnutrition, alone and combined, on the seizu...

journal_title：Addiction biology

authors： Palencia G,Calvillo M,Benita A,Sotelo J

更新日期：1998-10-01 00:00:00

abstract：:Inhibitory optogenetics was used to examine the roles of the prelimbic cortex (PL), the nucleus accumbens core (NAcore) and the PL projections to the NAcore in the reinstatement of cocaine seeking. Rats were microinjected into the PL or NAcore with an adeno-associated virus containing halorhodopsin or archaerhodopsin....

journal_title：Addiction biology

authors： Stefanik MT,Moussawi K,Kupchik YM,Smith KC,Miller RL,Huff ML,Deisseroth K,Kalivas PW,LaLumiere RT

更新日期：2013-01-01 00:00:00

abstract：:Exposure to smoking-associated environmental cues during smoke cessation elicits self-reported urge/craving to smoke, which precipitates relapse even after prolonged abstinence. Incubation of cue-induced cigarettes craving during abstinence has been observed in human smokers recently. The present studies assessed cue-...

journal_title：Addiction biology

authors： Markou A,Li J,Tse K,Li X

更新日期：2018-01-01 00:00:00

abstract：:Extracellular glycine modulates accumbal dopamine levels as well as ethanol-induced dopamine overflow. Glycine availability is also crucial for regulating alcohol consumption and the glycine transporter 1 (GlyT-1) inhibitor Org25935 robustly decreases alcohol intake in rats. To explore whether the alcohol-intake reduc...

journal_title：Addiction biology

authors： Lidö HH,Marston H,Ericson M,Söderpalm B

更新日期：2012-09-01 00:00:00

abstract：:Phosphatidylethanol (PEth), a direct ethanol metabolite, is detectable in blood for more than 2 weeks after sustained ethanol intake. Our aim was to assess the usefulness of PEth [comparing sensitivity, specificity and the area under the curve (AUC)] as compared with carbohydrate-deficient transferrin (CDT), gamma-glu...

journal_title：Addiction biology

authors： Hartmann S,Aradottir S,Graf M,Wiesbeck G,Lesch O,Ramskogler K,Wolfersdorf M,Alling C,Wurst FM

更新日期：2007-03-01 00:00:00