Optogenetic inhibition of cocaine seeking in rats.

abstract：:Ethyl glucuronide (EtG) is a promising new biological state marker of recent alcohol consumption that detects alcohol use reliably over a definite time period. Other currently available markers lack acceptable sensitivity and specificity. Our aim is to elucidate under naturalistic conditions the time course of EtG exc...

journal_title：Addiction biology

authors： Wurst FM,Seidl S,Ladewig D,Müller-Spahn F,Alt A

更新日期：2002-10-01 00:00:00

abstract：:Poor working memory is linked to future risk-taking behaviors. Lifelong risk of habitual drug use is highest in individuals who initiate use in early adolescence. We sought to determine in rats whether juvenile traits, specifically poor working memory and low salivary brain-derived neurotrophic factor (BDNF), are rela...

journal_title：Addiction biology

authors： Jordan CJ,Andersen SL

更新日期：2018-05-01 00:00:00

abstract：:Previous findings have shown that sigma-1 receptors (Sig-1Rs) are upregulated by the self-administration of methamphetamine, whereas Sig-1R antisense can attenuate the behavioral effects of psychostimulants in rodents. Sig-1R is an endoplasmic reticulum chaperone protein. However, the effects of Sig-1R agonist on the ...

journal_title：Addiction biology

authors： Mori T,Rahmadi M,Yoshizawa K,Itoh T,Shibasaki M,Suzuki T

更新日期：2014-05-01 00:00:00

abstract：:The insula has been implicated in salience processing, craving, and interoception, all of which are critical to the clinical manifestations of drug and behavioral addiction. In this functional magnetic resonance imaging (fMRI) study, we examined resting-state functional connectivity (rsFC) of the insula and its associ...

journal_title：Addiction biology

authors： Zhang JT,Yao YW,Li CS,Zang YF,Shen ZJ,Liu L,Wang LJ,Liu B,Fang XY

更新日期：2016-05-01 00:00:00

abstract：:Abuse of Δ⁹-THC by females during adolescence may produce long-term deficits in complex behavioral processes such as learning, and these deficits may be affected by the presence of ovarian hormones. To assess this possibility, 40 injections of saline or 5.6 mg/kg of Δ⁹-THC were administered i.p. daily during adolescen...

journal_title：Addiction biology

authors： Winsauer PJ,Daniel JM,Filipeanu CM,Leonard ST,Hulst JL,Rodgers SP,Lassen-Greene CL,Sutton JL

更新日期：2011-01-01 00:00:00

abstract：:This study investigated the effects of chronic ethanol intake on hepatic haemodynamics and reticuloendothelial system function in the rat. Comparisons were also made with blood flow to pancreas, kidney, spleen, lung and skin. Male Wistar rats, approximately 0.15 kg initial body weight, were fed a diet containing 35% o...

journal_title：Addiction biology

authors： Preedy VR,Nott DM,Yates J,Venkatesan S,Jenkins SA,Peters TJ

更新日期：1997-10-01 00:00:00

abstract：:The striatum, a major central nervous system structure modulating movement, is enriched with glutamatergic and dopaminergic innervation. By altering activities of both glutamatergic and dopaminergic transmissions the psychostimulants, amphetamine and cocaine, induce behavioral changes in experimental animals. Activati...

journal_title：Addiction biology

authors： Wang JQ,McGinty JF

更新日期：1999-04-01 00:00:00

abstract：:Neuroadaptations that participate in the ontogeny of alcohol dependence are likely a result of altered gene expression in various brain regions. The present study investigated brain region-specific changes in the pattern and magnitude of gene expression immediately following chronic intermittent ethanol (CIE) exposure...

journal_title：Addiction biology

authors： Melendez RI,McGinty JF,Kalivas PW,Becker HC

更新日期：2012-03-01 00:00:00

abstract：:Relapse into drug use is a major problem faced by recovering addicts. In humans, an intensification of the desire for the drug induced by environmental cues-incubation of drug craving-has been observed. In rodents, this phenomenon has been modeled by studying drug seeking under extinction after different times of drug...

journal_title：Addiction biology

authors： Roura-Martínez D,Ucha M,Orihuel J,Ballesteros-Yáñez I,Castillo CA,Marcos A,Ambrosio E,Higuera-Matas A

更新日期：2020-03-01 00:00:00

abstract：:Internet use and on-line game play stimulate corticostriatal-limbic circuitry in both healthy subjects and subjects with Internet gaming disorder (IGD). We hypothesized that increased fractional anisotropy (FA) with decreased radial diffusivity (RD) would be observed in IGD subjects, compared with healthy control subj...

journal_title：Addiction biology

authors： Jeong BS,Han DH,Kim SM,Lee SW,Renshaw PF

更新日期：2016-05-01 00:00:00

abstract：:The posterior hippocampus (pHp) plays a major role in the processing and storage of drug-related cues and is linked to striatal-limbic brain circuits involved with craving and drug salience. We have recently reported that increased basal regional cerebral blood flow (rCBF) in a pHp loci, as measured by pseudo-continuo...

journal_title：Addiction biology

authors： Adinoff B,Harris TS,Gu H,Stein EA

更新日期：2017-05-01 00:00:00

abstract：:Patients in methadone maintenance programmes (MMT) often smoke tobacco and cannabis and many have ongoing illicit drug use. There is therefore potential for these patients to have abnormal cardiorespiratory function; however, few studies address this in stable MMT patients. We assessed resting cardiorespiratory functi...

journal_title：Addiction biology

authors： Teichtahl H,Wang D,Cunnington D,Kronborg I,Goodman C,Prodromidis A,Drummer O

更新日期：2004-09-01 00:00:00

abstract：:Identifying addicts with higher risk of relapse would provide the opportunity to implement individualized interventions and increase cessation success rates. Unfortunately, the ability to predict the long-term success of drug cessation treatments continues to elude researchers. We tested whether brain responses to emo...

journal_title：Addiction biology

authors： Versace F,Lam CY,Engelmann JM,Robinson JD,Minnix JA,Brown VL,Cinciripini PM

更新日期：2012-11-01 00:00:00

abstract：:Psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) is the major psychoactive alkaloid of some species of mushrooms distributed worldwide. These mushrooms represent a growing problem regarding hallucinogenic drug abuse. Despite its experimental medical use in the 1960s, only very few pharmacological data about psilocy...

journal_title：Addiction biology

authors： Passie T,Seifert J,Schneider U,Emrich HM

更新日期：2002-10-01 00:00:00

abstract：:It has been suggested that the attention towards alcohol-related stimuli increases with the duration of drinking and alcohol dependence. The present study aimed to assess whether an attentional bias was present in detoxified alcohol-dependent patients, and if the magnitude of the attentional bias depended on the subje...

journal_title：Addiction biology

authors： Loeber S,Vollstädt-Klein S,von der Goltz C,Flor H,Mann K,Kiefer F

更新日期：2009-04-01 00:00:00

abstract：:Following recent advances in neuromodulation therapy for mental disorders, we treated one patient with severe alcohol addiction with deep brain stimulation (DBS) of the nucleus accumbens (NAc). Before and one year following the surgery, we assessed the effects of DBS within the NAc on the addiction as well as on psych...

journal_title：Addiction biology

authors： Kuhn J,Gründler TO,Bauer R,Huff W,Fischer AG,Lenartz D,Maarouf M,Bührle C,Klosterkötter J,Ullsperger M,Sturm V

更新日期：2011-10-01 00:00:00

abstract：:The α1 -adrenergic antagonist, doxazosin, has improved cocaine use disorder (CUD) presumably by blocking norepinephrine (NE) stimulation and reward from cocaine-induced NE increases. If the NE levels for release were lower, then doxazosin might more readily block this NE stimulation and be more effective. The NE avail...

journal_title：Addiction biology

authors： Zhang X,Nielsen DA,Domingo CB,Shorter DI,Nielsen EM,Kosten TR

更新日期：2019-05-01 00:00:00

abstract：:Ketamine, a non-competitive N-methyl-D-aspartic acid receptor antagonist, has emerged as an increasingly popular drug among young drug abusers worldwide. Available evidence suggests that ketamine produces acute impairments of working, episodic and semantic memory along with psychotogenic and dissociative effects when ...

journal_title：Addiction biology

authors： Sun L,Li Q,Li Q,Zhang Y,Liu D,Jiang H,Pan F,Yew DT

更新日期：2014-03-01 00:00:00

abstract：:The purpose of this study was to evaluate the effects of naltrexone (0.7 mg/kg) and/or topiramate (25 mg/kg) on ethanol consumption and the motivation to drink in an oral-operant conditioning paradigm in C57BL/6 mice. Subsequent real-time polymerase chain reaction (PCR) experiments were performed to analyze gene expre...

journal_title：Addiction biology

authors： Navarrete F,Rubio G,Manzanares J

更新日期：2014-09-01 00:00:00

abstract：:Drug addiction is a chronic and relapsing brain disorder, influenced by complex interactions between endogenous and exogenous factors. Per2, a circadian gene, plays a role in drug addiction. Previous studies using Per2-knockout mice have shown a role for Per2 in cocaine, morphine and alcohol addiction. In the present ...

journal_title：Addiction biology

authors： Kim M,Custodio RJ,Botanas CJ,de la Peña JB,Sayson LV,Abiero A,Ryoo ZY,Cheong JH,Kim HJ

更新日期：2019-09-01 00:00:00

abstract：:Chronic inhalation of volatile solvents induce severe brain damage. In humans, intense exposure to volatile solvents for recreational purposes is frequently associated with chronic malnutrition. We studied in rats the effects of chronic inhalation of volatile solvents and malnutrition, alone and combined, on the seizu...

journal_title：Addiction biology

authors： Palencia G,Calvillo M,Benita A,Sotelo J

更新日期：1998-10-01 00:00:00

abstract：:The supply of substitute opioid medication as a treatment for heroin dependence is now common practice. There is growing international interest in the prescription of injectable diamorphine for subgroups of patients who are unable to stop injecting opiate drugs; in the United Kingdom it is estimated that there are cur...

journal_title：Addiction biology

authors： McLachlan-Troup N,Taylor GW,Trathen BC

更新日期：2001-07-01 00:00:00

abstract：:The capacity of the liver to synthesize insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) may be compromised by alcohol. The characteristics of IGFBP-3 variants obtained from healthy individuals and patients with alcoholic cirrhosis (ALC) were compared. Concanavalin A (Con A) affinity electrophore...

journal_title：Addiction biology

authors： Nedić O,Nikolić JA,Prisić S,Acimovic J,hajdukovic-Dragojlovic L

更新日期：2003-03-01 00:00:00

abstract：:The aim of this study was to profile and compare blood naltrexone and 6-beta-naltrexol levels with time following treatment with two sustained-release naltrexone preparations produced by GoMedical Industries, Australia at a community heroin treatment clinic in Perth, Western Australia. A sample of 10 patients who each...

journal_title：Addiction biology

authors： Hulse GK,Arnold-Reed DE,O'Neil G,Chan CT,Hansson R,O'Neil P

更新日期：2004-03-01 00:00:00

abstract：:Positive and negative emotional experiences induced by addictive drugs play an important role in the development of dysfunctional drug-related memory, which becomes resistant to extinction and contributes to high rate of relapse. Those memories may undergo a process called reconsolidation that in some cases can be dis...

journal_title：Addiction biology

authors： Wu Y,Li Y,Yang X,Sui N

更新日期：2014-01-01 00:00:00

abstract：:The high prevalence of psychostimulant abuse observed in schizophrenic patients may be related to the development of mesolimbic dopaminergic supersensitivity (MDS) or nigrostriatal dopaminergic supersensitivity (NDS) in response to the chronic blockade of dopamine receptors produced by typical neuroleptic treatment. W...

journal_title：Addiction biology

authors： Carvalho RC,Fukushiro DF,Helfer DC,Callegaro-Filho D,Trombin TF,Zanlorenci LH,Sanday L,Silva RH,Frussa-Filho R

更新日期：2009-07-01 00:00:00

abstract：:The rate of acetaldehyde metabolism was measured in aortic rings from rat strains genetically bred for high (UChB) and low (UChA) voluntary ethanol consumption. The results show that in aortic rings from naive UChB rats, acetaldehyde oxidation rates were significantly greater than the rates observed in aortic rings fr...

journal_title：Addiction biology

authors： Quintanilla ME,Tampier L

更新日期：1999-01-01 00:00:00

abstract：:Mixing alcohol with caffeinated energy drinks is a common practice, especially among young people. In humans, the research on this issue has mainly focused on the use of the mass-marketed energy drinks themselves, whereas in animal models, it has focused on the individual effects of their active ingredients (i.e. caff...

journal_title：Addiction biology

authors： Roldán M,Echeverry-Alzate V,Bühler KM,Sánchez-Diez IJ,Calleja-Conde J,Olmos P,Boehm SL,Maldonado R,Rodríguez de Fonseca F,Santiago C,Gómez-Gallego F,Giné E,López-Moreno JA

更新日期：2018-09-01 00:00:00

abstract：:Withdrawal from extended-access cocaine self-administration leads to progressive intensification ('incubation') of cocaine craving. After prolonged withdrawal (1-2 months), when craving is high, expression of incubation depends on strengthening of excitatory inputs to medium spiny neurons (MSN) of the nucleus accumben...

journal_title：Addiction biology

authors： Purgianto A,Weinfeld ME,Wolf ME

更新日期：2017-11-01 00:00:00

abstract：:α-Synuclein has recently been implicated in the pathophysiology of alcohol abuse due to its role in dopaminergic neurotransmission. In these studies, genetic variability in the α-synuclein gene influences its expression which may contribute to susceptibility to chronic alcohol abuse. Real-time PCR was used to quantify...

journal_title：Addiction biology

authors： Janeczek P,MacKay RK,Lea RA,Dodd PR,Lewohl JM

更新日期：2014-05-01 00:00:00