Abstract：
:Previous findings have shown that sigma-1 receptors (Sig-1Rs) are upregulated by the self-administration of methamphetamine, whereas Sig-1R antisense can attenuate the behavioral effects of psychostimulants in rodents. Sig-1R is an endoplasmic reticulum chaperone protein. However, the effects of Sig-1R agonist on the rewarding effects of abused drugs are not fully understood. Therefore, we examined the effects of selective Sig-1R agonists, such as SA4503 and (+)-pentazocine, on the rewarding effects of abused drugs such as methamphetamine, cocaine and morphine in rats, as measured by the conditioned place preference. Methamphetamine, cocaine and morphine induced a significant place preference. SA4503, but not (+)-pentazocine, significantly attenuated the abused drug-induced place preference. We recently showed that (+)-pentazocine exerts U50,488H-like discriminative stimulus effects, which are related to its psychotomimetic/aversive effects. However, SA4503 did not generalize to the discriminative stimulus effects of U50,488H. These results suggest that SA4503 inhibits the rewarding effects of abused drugs, and that psychotomimetic/aversive effects may not play a role in the attenuating effects of SA4503 on the rewarding effects of abused drugs.
journal_name
Addict Bioljournal_title
Addiction biologyauthors
Mori T,Rahmadi M,Yoshizawa K,Itoh T,Shibasaki M,Suzuki Tdoi
10.1111/j.1369-1600.2012.00488.xsubject
Has Abstractpub_date
2014-05-01 00:00:00pages
362-9issue
3eissn
1355-6215issn
1369-1600journal_volume
19pub_type
杂志文章abstract：:Two analytical techniques (RIA and GC-MS) were used for the simultaneous identification and determination of heroin, cocaine and their metabolites in the urine and hair of 200 drug addicts. Opiates tests were positive in 182 hair samples and 145 urine samples, whereas cocaine tests were positive in 173 hair samples an...
journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/13556219971407
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journal_title：Addiction biology
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journal_title：Addiction biology
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journal_title：Addiction biology
pub_type： 杂志文章
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更新日期：2020-01-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/13556219872074
更新日期：1998-07-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12277
更新日期：2016-03-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/1355621031000069927
更新日期：2003-03-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/j.1369-1600.2000.tb00211.x
更新日期：2000-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2010-10-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
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更新日期：1996-01-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12797
更新日期：2020-09-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
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更新日期：2003-12-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/13556210071289
更新日期：2000-01-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12765
更新日期：2020-05-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/j.1369-1600.2010.00270.x
更新日期：2012-05-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/13556219971641
更新日期：1999-04-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12890
更新日期：2020-03-05 00:00:00
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journal_title：Addiction biology
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doi：10.1111/j.1369-1600.2011.00393.x
更新日期：2013-05-01 00:00:00
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更新日期：2017-05-01 00:00:00
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journal_title：Addiction biology
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更新日期：2012-01-01 00:00:00
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pub_type： 评论,杂志文章
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更新日期：2017-01-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
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更新日期：2018-09-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章,评审
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更新日期：2016-01-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1080/13556219772507
更新日期：1997-10-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
doi：10.1111/adb.12820
更新日期：2020-07-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
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更新日期：2018-01-01 00:00:00
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journal_title：Addiction biology
pub_type： 杂志文章
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更新日期：2017-03-01 00:00:00
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journal_title：Addiction biology
pub_type： 临床试验,杂志文章
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更新日期：2002-04-01 00:00:00
abstract：:Alcohol use disorder is a chronic, relapsing brain disorder causing substantial morbidity and mortality. Cholinergic interneurons (CIN) within the nucleus accumbens (nAc) have been suggested to exert a regulatory impact on dopamine (DA) neurotransmission locally, and defects in CIN have been implied in several psychia...
journal_title：Addiction biology
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更新日期：2020-08-13 00:00:00
